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    Quinolonecarboxylic acid derivatives and their preparation
    1.
    发明授权
    Quinolonecarboxylic acid derivatives and their preparation 失效
    喹诺酮羧酸衍生物及其制备方法

    公开(公告)号：US4894458A

    公开(公告)日：1990-01-16

    申请号：US233363

    申请日：1988-08-18

    申请人： Kuniyoshi Masuzawa ,  Seigo Suzue ,  Keiji Hirai ,  Takayoshi Ishizaki

    发明人： Kuniyoshi Masuzawa ,  Seigo Suzue ,  Keiji Hirai ,  Takayoshi Ishizaki

    IPC分类号： A61K31/47 ,  A61K31/495 ,  A61K31/55 ,  A61P31/04 ,  C07D215/56 ,  C07D401/04

    CPC分类号： C07D215/56 ,  C07D401/04

    摘要： Quinolonecarboxylic acid derivatives of the following formula, ##STR1## wherein R indicates straight or branched lower alkyl, R.sup.1 indicates cycloalkyl having 3 to 6 carbon atoms, straight or branched lower alkyl, halogenoalkyl, alkenyl, hydroxyalkyl, lower alkylamino or substituted or non-substituted phenyl, R.sup.2 indicates hydrogen, halogen, nitro or amino, X indicates halogen, Z indicates halogen, azetidino, pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino or homopiperazino of the following formula, ##STR2## (here, n is 1 or 2, R.sup.3 indicates hydrogen, lower alkyl, lower acyl, acyloxycarbonyl or benzyl, R.sup.4 and R.sup.5 indicate hydrogen, lower alkyl, aminoalkyl, hydroxyalkyl or phenyl each independently), or pyrrolidino or piperidino of the following formula, ##STR3## (here, k is 0, 1 or 2, l is 0, 1 or 2, m is 0 or 1, R.sup.6 indicates hydrogen, lower alkyl or hydroxy, R.sup.7 indicates hydrogen, lower alkyl, halogenoalkyl or hydroxyalkyl, R.sup.8 indicates hydrogen, lower alkyl, lower acyl, alkoxycarbonyl or benzyl), the hydrates and pharmaceutically acceptable acid addition or alkali salts thereof are useful as antibacterial agents.

    摘要翻译： 下式的喹诺酮羧酸衍生物，其中R表示直链或支链的低级烷基，R1表示碳原子数为3〜6的环烷基，直链或支链的低级烷基，卤代烷基，链烯基，羟基烷基，低级烷基氨基或取代或未取代的 苯基，R 2表示氢，卤素，硝基或氨基，X表示卤素，Z表示卤素，氮杂环丁烷基，吡咯烷子基，哌啶子基，吗啉代，硫代吗啉代，哌嗪基或下式的高哌嗪基：（这里，n为1或2， R3表示氢，低级烷基，低级酰基，酰氧基羰基或苄基，R4和R5表示氢，低级烷基，氨基烷基，羟基烷基或苯基各自独立地），或下式的吡咯烷子基或哌啶子基，其中， ，1或2，l为0,1或2，m为0或1，R6表示氢，低级烷基或羟基，R7表示氢，低级烷基，卤代烷基或羟烷基，R8表示氢，低级烷基，低级酰基，烷氧基 羰基或苄基），其水合物及其药学上可接受的酸加成盐或碱盐可用作抗菌剂。

    8-alkoxyquinolonecarboxylic acid and salts thereof
    3.
    发明授权
    8-alkoxyquinolonecarboxylic acid and salts thereof 失效
    8-烷氧基喹诺酮羧酸及其盐

    公开(公告)号：US4980470A

    公开(公告)日：1990-12-25

    申请号：US3822

    申请日：1987-01-16

    申请人： Kuniyoshi Masuzawa ,  Seigo Suzue ,  Keiji Hirai ,  Takayoshi Ishizaki

    发明人： Kuniyoshi Masuzawa ,  Seigo Suzue ,  Keiji Hirai ,  Takayoshi Ishizaki

    IPC分类号： A61K31/47 ,  A61K31/495 ,  A61P31/04 ,  C07D215/56 ,  C07D401/04

    CPC分类号： C07D215/56 ,  C07D401/04

    摘要： Quinolonecarboxylic acid derivatives of the following formula: ##STR1## wherein R indicates a hydrogen atom or lower alkyl group, R.sup.1 indicates a lower alkyl group, R.sup.2 indicates a hydrogen atom, amino group or nitro group, X indicates a halogen atom, and Z indicates a halogen atom, piperazino group, N-methylpiperazino group, 3-methylpiperazino group, 3-hydroxypyrrolidino group, or pyrrolidino group of the following formula, ##STR2## (here, n is 0 or 1, R.sup.3 indicates a hydrogen atom or lower alkyl group, R.sup.4 indicates a hydrogen atom, lower alkyl group and R.sup.5 indicates a hydrogen atom, lower alkyl group, acyl group or alkoxycarbonyl group), the hydrates and pharmaceutically acceptable salts thereof are useful as antibacterial agents.

    摘要翻译： 下式的喹诺酮羧酸衍生物：其中R表示氢原子或低级烷基，R1表示低级烷基，R2表示氢原子，氨基或硝基，X表示卤素原子，Z表示 卤素原子，哌嗪子基，N-甲基哌嗪基，3-甲基哌嗪基，3-羟基吡咯烷子基或下式的吡咯烷子基（这里，n为0或1，R 3表示氢原子或低级烷基 基团，R4表示氢原子，低级烷基，R5表示氢原子，低级烷基，酰基或烷氧基羰基），其水合物及其药学上可接受的盐可用作抗菌剂。

    Benzimidazole Derivatives
    4.
    发明授权
    Benzimidazole Derivatives 失效
    苯并咪唑衍生物

    公开(公告)号：US4942245A

    公开(公告)日：1990-07-17

    申请号：US180065

    申请日：1988-04-11

    申请人： Kuniyoshi Masuzawa ,  Kyuya Okamura ,  Keigo Nishino ,  Mitsuo Ohashi ,  Katsuya Awano

    发明人： Kuniyoshi Masuzawa ,  Kyuya Okamura ,  Keigo Nishino ,  Mitsuo Ohashi ,  Katsuya Awano

    IPC分类号： C07D235/12 ,  C07D235/28

    CPC分类号： C07D235/28 ,  C07D235/12

    摘要： Benzimidazole derivatives of the following formula, ##STR1## wherein R.sup.1 indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 6 or dimethylaminopropyl group, R.sup.2 indicates hydrogen atom or lower alkanoyl group having carbon atoms of 1 to 3, R.sup.3 indicates hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or lower alkanoyl group having carbon atoms of 1 to 3, X indicates sulfur atom, sulfinyl group, sulfonyl group, amino group or methylene group, A indicates alkylene group having carbon atoms of 1 to 12, which alkylene group may optionally be substituted by hydroxy group or lower alkyl group having carbon atoms of 1 to 3, --(CHR')N--CR".dbd.CR"--(CHR')M--, ##STR2## (in which R' and R" are each independently hydrogen atom, lower alkyl group having carbon atoms of 1 to 3 or hydroxy group, and n and m are equal to 0, 1, 2 or 3) and Y indicates oxygen atom or sulfur atom; their acid or alkali salts and hydrate thereof are useful as antiallergic agents.

    8-alkoxyquinolonecarboxylic acid and salts thereof
    7.
    发明授权
    8-alkoxyquinolonecarboxylic acid and salts thereof 失效
    8-烷氧基喹诺酮羧酸及其盐

    公开(公告)号：US5043450A

    公开(公告)日：1991-08-27

    申请号：US600828

    申请日：1990-10-22

    申请人： Kuniyoshi Masuzawa ,  Seigo Suzue ,  Keiji Hirai ,  Takayoshi Ishizaki

    发明人： Kuniyoshi Masuzawa ,  Seigo Suzue ,  Keiji Hirai ,  Takayoshi Ishizaki

    IPC分类号： A61K31/47 ,  A61K31/495 ,  A61P31/04 ,  C07D215/56 ,  C07D401/04

    CPC分类号： C07D215/56 ,  C07D401/04

    摘要： Quinolonecarboxylic acid derivatives of the following formula, ##STR1## wherein R indicates a hydrogen atom or lower alkyl group, R.sup.1 indicates a lower alkyl group, R.sup.2 indicates a hydrogen atom, amino group or nitro group, X indicates a halogen atom, and Z indicates a halogen atom, piperazino group, N-methylpiperazino group, 3-methylpiperazino group, 3-hydroxypyrrolidino group, or pyrrolidino group of the following formula, ##STR2## (here, n is 0 or 1, R.sup.3 indicates a hydrogen atom or lower alkyl group, R.sup.4 indicates a hydrogen atom, lower alkyl group or substituted lower alkyl group and R.sup.5 indicates a hydrogen atom, lower alkyl group, acyl group or alkoxycarbonyl group), the hydrates and pharmaceutically acceptable salts thereof are useful as antibacterial agents.