公开(公告)号：US20120052573A1

公开(公告)日：2012-03-01

申请号：US12868939

申请日：2010-08-26

Applicant: Shu-Yi LIN ,  Fong-Sian LIN ,  Meng-Kai CHEN ,  Yu-Chen JAO ,  Lin-Ren TSAI ,  Hong-Yi LIN ,  Chung-Shi YANG ,  Yeu-Kuang HWU

Inventor： Shu-Yi LIN ,  Fong-Sian LIN ,  Meng-Kai CHEN ,  Yu-Chen JAO ,  Lin-Ren TSAI ,  Hong-Yi LIN ,  Chung-Shi YANG ,  Yeu-Kuang HWU

IPC: C12N5/09 ,  A61K31/7088 ,  C08G73/00

CPC classification number: C08G73/0206 ,  C08G73/0213 ,  C08L79/02

Abstract: A method of synthesizing polyethyleneimine with a substantially linear backbone is disclosed. The method comprises exposing ethylenediamine dissolved in a solution to electromagnetic radiation for a sufficient time to polymerize the ethylenediamine and thereby resulting in formation of polyethylenimine with a substantially linear backbone in the solution. A method of synthesizing a homopolymer with a substantially linear backbone is also disclosed. In addition, a composition comprising polyethylenimine synthesized from the aforementioned method is disclosed, in which the polyethylenimine comprises a backbone conformation that is substantially linear and has a distribution of molecular weights (MW) ranging from 1 kDa to 200 kDa; and the polyethyleneimine has no cytotoxicity at a concentration of 12 μg/ml.

Abstract translation: 公开了一种合成具有基本线性主链的聚亚乙基亚胺的方法。 该方法包括将溶解在溶液中的乙二胺暴露于电磁辐射足够的时间以使乙二胺聚合，从而导致在溶液中形成具有基本线性主链的聚乙烯亚胺。 还公开了一种合成具有基本线性主链的均聚物的方法。 另外，公开了包含由上述方法合成的聚乙烯亚胺的组合物，其中聚乙烯亚胺包括基本上线性且具有范围从1kDa至200kDa的分子量（MW）分布的主链构型; 并且聚乙烯亚胺在12μg/ ml的浓度下没有细胞毒性。