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    Systems and methods for designing and ordering polynucleotides
    1.
    发明授权
    Systems and methods for designing and ordering polynucleotides 有权
    用于设计和排序多核苷酸的系统和方法

    公开(公告)号：US07805252B2

    公开(公告)日：2010-09-28

    申请号：US11207151

    申请日：2005-08-16

    申请人： Claes Gustafsson ,  Sridhar Govindarajan ,  Jon E. Ness ,  Alan Marco Villalobos ,  Jeremy Minshull

    发明人： Claes Gustafsson ,  Sridhar Govindarajan ,  Jon E. Ness ,  Alan Marco Villalobos ,  Jeremy Minshull

    IPC分类号： G06F7/00

    CPC分类号： G06F19/26 ,  G06F19/18 ,  G06F19/20

    摘要： Computer systems, computer program products and methods for designing oligonucleotides are provided. A set of sequence elements is defined. Each sequence element represents an amino acid sequence segment or a nucleic acid sequence segment. The set of sequence elements collectively represent a design nucleic acid sequence. The set of sequence elements are displayed as a plurality icons in a linear or a near linear arrangement such that each respective icon in the plurality of icons uniquely represents a corresponding sequence element in the set of sequence elements. In this representation, neighboring icons in the plurality of icons represent neighboring sequence elements in the set of sequence elements. Each respective icon in the plurality of icons depicts a directional property for the corresponding sequence element in the set of sequence elements. An oligonucleotide selection module is used to identify oligonucleotides in the design nucleic acid sequence.

    摘要翻译： 提供计算机系统，计算机程序产品和设计寡核苷酸的方法。 定义了一组序列元素。 每个序列元件代表氨基酸序列片段或核酸序列片段。 序列元件的集合统称为设计核酸序列。 序列元素的集合被显示为线性或近似线性布置的多个图标，使得多个图标中的每个相应图标唯一地表示序列元素集合中的相应序列元素。 在该表示中，多个图标中的相邻图标表示该组序列元素中的相邻序列元素。 多个图标中的每个相应的图标描绘了序列元素集合中相应的序列元素的方向属性。 寡核苷酸选择模块用于鉴定设计核酸序列中的寡核苷酸。

    PROCESS FOR CONTINUOUS PRODUCTION OF REACTIVE POLYMERS WITH IN-LINE POST-MODIFICATION AND PRODUCTS THEREOF
    2.
    发明申请
    PROCESS FOR CONTINUOUS PRODUCTION OF REACTIVE POLYMERS WITH IN-LINE POST-MODIFICATION AND PRODUCTS THEREOF 审中-公开
    连续改性反应性聚合物的生产工艺及其制品

    公开(公告)号：US20070265399A1

    公开(公告)日：2007-11-15

    申请号：US11627668

    申请日：2007-01-26

    申请人： David Schatz ,  Warunee Srisiri-Sisson ,  Marco Villalobos ,  Michihiro Kaai ,  Yasuhiko Mori

    发明人： David Schatz ,  Warunee Srisiri-Sisson ,  Marco Villalobos ,  Michihiro Kaai ,  Yasuhiko Mori

    IPC分类号： C08F2/00

    CPC分类号： C08F8/14 ,  C08F2810/30

    摘要： A continuous polymerization process for producing reactive polymers comprises continuously charging into a first reaction zone at least one functional monomer and polymerizing the monomers to produce a first polymeric product having at least one functional group. This first polymeric product is then continuously directly charged into a second reaction zone together with at least one modifier reactant having a functional group that is complementary to the functional group of the first polymeric product. At least a portion of the modifier reactant reacts with at least one of the functional groups of the first polymeric product to produce a second polymeric product which incorporates at least a portion of the modifier reactant, such that the second polymeric product is a reactive polymer.

    摘要翻译： 用于制备反应性聚合物的连续聚合方法包括将至少一种官能单体连续地装入第一反应区域并使单体聚合以产生具有至少一个官能团的第一聚合物产物。 然后将该第一聚合物产物与至少一种具有与第一聚合物产物的官能团互补的官能团的改性剂反应物连续地直接装入第二反应区。 至少一部分改性剂反应物与第一聚合产物的至少一个官能团反应以产生第二聚合物产物，其中至少一部分改性剂反应物，使得第二聚合物产物是反应性聚合物。