公开(公告)号：US20140275013A1

公开(公告)日：2014-09-18

申请号：US14209536

申请日：2014-03-13

申请人： Arnab Kumar CHATTERJEE ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Pranab Kumar MISHRA ,  Valentina MOLTENI ,  Advait Suresh Nagle ,  Frantisek SUPEK ,  Liying Jocelyn TAN ,  Agnes VIDAL ,  Michael Herman GELB ,  Frederick Simmons BUCKNER ,  Hari Babu TATIPAKA ,  Neil Richard NORCROSS ,  John Robert GILLESPIE

发明人： Arnab Kumar CHATTERJEE ,  Fang LIANG ,  Casey Jacob Nelson MATHISON ,  Pranab Kumar MISHRA ,  Valentina MOLTENI ,  Advait Suresh Nagle ,  Frantisek SUPEK ,  Liying Jocelyn TAN ,  Agnes VIDAL ,  Michael Herman GELB ,  Frederick Simmons BUCKNER ,  Hari Babu TATIPAKA ,  Neil Richard NORCROSS ,  John Robert GILLESPIE

IPC分类号： C07D473/00 ,  C07D471/04

CPC分类号： C07D473/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

公开(公告)号：US09233961B2

公开(公告)日：2016-01-12

申请号：US14209536

申请日：2014-03-13

申请人： Arnab Kumar Chatterjee ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal ,  Michael Herman Gelb ,  Frederick Simmons Buckner ,  Hari Babu Tatipaka ,  Neil Richard Norcross ,  John Robert Gillespie

发明人： Arnab Kumar Chatterjee ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal ,  Michael Herman Gelb ,  Frederick Simmons Buckner ,  Hari Babu Tatipaka ,  Neil Richard Norcross ,  John Robert Gillespie

IPC分类号： C07D471/02 ,  A61K31/50 ,  A61K31/415 ,  C07D473/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

CPC分类号： C07D473/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.