公开(公告)号：US09233961B2

公开(公告)日：2016-01-12

申请号：US14209536

申请日：2014-03-13

申请人： Arnab Kumar Chatterjee ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal ,  Michael Herman Gelb ,  Frederick Simmons Buckner ,  Hari Babu Tatipaka ,  Neil Richard Norcross ,  John Robert Gillespie

发明人： Arnab Kumar Chatterjee ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal ,  Michael Herman Gelb ,  Frederick Simmons Buckner ,  Hari Babu Tatipaka ,  Neil Richard Norcross ,  John Robert Gillespie

IPC分类号： C07D471/02 ,  A61K31/50 ,  A61K31/415 ,  C07D473/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

CPC分类号： C07D473/00 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

摘要： The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

公开(公告)号：US09186361B2

公开(公告)日：2015-11-17

申请号：US14209655

申请日：2014-03-13

申请人： Arnab Kumar Chatterjee ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal

发明人： Arnab Kumar Chatterjee ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Pranab Kumar Mishra ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Liying Jocelyn Tan ,  Agnes Vidal

IPC分类号： A01N43/42 ,  A61K31/44 ,  A61K31/5377 ,  A61K31/437 ,  A61K45/06 ,  C07D471/04 ,  C07D498/04

CPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K45/06 ,  C07D471/04 ,  C07D498/04 ,  Y02A50/409 ,  Y02A50/414 ,  Y02A50/415

摘要： The present invention provides compounds of Formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯 疾病。

公开(公告)号：US09303034B2

公开(公告)日：2016-04-05

申请号：US14574775

申请日：2014-12-18

申请人： Agnes Biggart ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Vince Yeh

发明人： Agnes Biggart ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Vince Yeh

IPC分类号： A61K31/519 ,  C07D487/04 ,  C07D519/00 ,  C07F5/02 ,  C07F7/08

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F5/027 ,  C07F7/0814

摘要： The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.

摘要翻译： 本发明提供式A化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供了包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和查加斯 疾病。

公开(公告)号：US09700559B2

公开(公告)日：2017-07-11

申请号：US15051446

申请日：2016-02-23

申请人： Agnes Biggart ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Vince Yeh

发明人： Agnes Biggart ,  Fang Liang ,  Casey Jacob Nelson Mathison ,  Valentina Molteni ,  Advait Suresh Nagle ,  Frantisek Supek ,  Vince Yeh

IPC分类号： C07D487/04 ,  A61K31/519 ,  C07D519/00 ,  C07F5/02 ,  C07F7/08 ,  A61K31/5377 ,  A61K31/695

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/695 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F5/027 ,  C07F7/0814

摘要： The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.