公开(公告)号：US20060074073A1

公开(公告)日：2006-04-06

申请号：US11231470

申请日：2005-09-20

申请人： Heidi Marie Steinfeldt ,  Theodore James Boritzki ,  Alan Hilary Calvert ,  Nicola Jane Curtin ,  Mohamed Raza Dewji ,  Zdenek Hostomsky ,  Christopher Jones ,  Rhonda Kaufman ,  Karen Klamerus ,  David Richard Newell ,  Elizabeth Ruth Plummer ,  Steven Reich ,  Ian Stratford ,  Huw David Thomas ,  Kay Janine Williams

发明人： Heidi Marie Steinfeldt ,  Theodore James Boritzki ,  Alan Hilary Calvert ,  Nicola Jane Curtin ,  Mohamed Raza Dewji ,  Zdenek Hostomsky ,  Christopher Jones ,  Rhonda Kaufman ,  Karen Klamerus ,  David Richard Newell ,  Elizabeth Ruth Plummer ,  Steven Reich ,  Ian Stratford ,  Huw David Thomas ,  Kay Janine Williams

IPC分类号： A61K31/55

CPC分类号： A61K31/704 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/513 ,  A61K31/519 ,  A61K31/55 ,  A61K33/24 ,  A61K41/00 ,  A61K2300/00

摘要： This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.

摘要翻译： 本发明一般涉及8-氟-2 {4 - [（甲基氨基）甲基]苯基} -1,3,4,5-四氢-6H-吖庚因并[5,4，3-cd] 由式1表示的化学敏感剂可增强细胞毒性药物或放射疗法的功效。 本发明提供8-氟-2 {4 - [（甲基氨基）甲基]苯基} -1,3,4,5-四氢-6H-吖庚因并[5,4，3-cd]吲哚-6-酮的药物组合 ，或其药学上可接受的盐和至少一种另外的治疗剂，含有这些组合的试剂盒和使用这些组合的方法来治疗患有疾病如癌症的受试者。