公开(公告)号：US20110212853A1

公开(公告)日：2011-09-01

申请号：US13030258

申请日：2011-02-18

申请人： Holger Cynis ,  Martin Kleinschmidt ,  Kathrin Gans ,  Jens-Ulrich Rahfeld ,  Hans-Ulrich Demuth ,  Nadine Taudte

发明人： Holger Cynis ,  Martin Kleinschmidt ,  Kathrin Gans ,  Jens-Ulrich Rahfeld ,  Hans-Ulrich Demuth ,  Nadine Taudte

IPC分类号： C40B30/04 ,  C12Q1/02 ,  C40B30/00 ,  G01N33/566

CPC分类号： G01N33/6893 ,  G01N33/574 ,  G01N2800/102 ,  G01N2800/2814

摘要： A method of monitoring treatment of an inflammatory disease or an inflammatory associated disease with the use of the ratio of N-terminal pyroglutamate modified MCP-1 (MCP-1 N1pE):total concentration of MCP-1 within a biological sample as a biomarker, and a method for determining the proportion of N-terminal pyroglutamate modified MCP-1 in relation to the total concentration of MCP-1 in biological samples. Also disclosed are a diagnostic kit and a method for screening a glutaminyl cyclase (QC) inhibitor or measuring the effectiveness of a glutaminyl cyclase (QC) inhibitor.

摘要翻译： 使用N-末端焦谷氨酸修饰的MCP-1（MCP-1N1pE）：生物样品中MCP-1的总浓度作为生物标志物的比例来监测炎性疾病或炎性相关疾病的治疗方法， 以及用于确定N-末端焦谷氨酸修饰的MCP-1的比例相对于生物样品中MCP-1的总浓度的方法。 还公开了诊断试剂盒和筛选谷氨酰胺酰基环化酶（QC）抑制剂或测量谷氨酰胺酰基环化酶（QC）抑制剂的有效性的方法。