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公开(公告)号：US20110212853A1
公开(公告)日：2011-09-01
申请号：US13030258
申请日：2011-02-18
申请人： Holger Cynis , Martin Kleinschmidt , Kathrin Gans , Jens-Ulrich Rahfeld , Hans-Ulrich Demuth , Nadine Taudte
发明人： Holger Cynis , Martin Kleinschmidt , Kathrin Gans , Jens-Ulrich Rahfeld , Hans-Ulrich Demuth , Nadine Taudte
IPC分类号： C40B30/04 , C12Q1/02 , C40B30/00 , G01N33/566
CPC分类号： G01N33/6893 , G01N33/574 , G01N2800/102 , G01N2800/2814
摘要： A method of monitoring treatment of an inflammatory disease or an inflammatory associated disease with the use of the ratio of N-terminal pyroglutamate modified MCP-1 (MCP-1 N1pE):total concentration of MCP-1 within a biological sample as a biomarker, and a method for determining the proportion of N-terminal pyroglutamate modified MCP-1 in relation to the total concentration of MCP-1 in biological samples. Also disclosed are a diagnostic kit and a method for screening a glutaminyl cyclase (QC) inhibitor or measuring the effectiveness of a glutaminyl cyclase (QC) inhibitor.
摘要翻译： 使用N-末端焦谷氨酸修饰的MCP-1（MCP-1N1pE）：生物样品中MCP-1的总浓度作为生物标志物的比例来监测炎性疾病或炎性相关疾病的治疗方法， 以及用于确定N-末端焦谷氨酸修饰的MCP-1的比例相对于生物样品中MCP-1的总浓度的方法。 还公开了诊断试剂盒和筛选谷氨酰胺酰基环化酶（QC）抑制剂或测量谷氨酰胺酰基环化酶（QC）抑制剂的有效性的方法。
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2.发明授权Antibodies directed against pyroglutamate monocyte chemoattractant protein-1 (MCP-1 N1pE) 有权针对焦谷氨酸单核细胞趋化蛋白-1（MCP-N1PE）的抗体公开(公告)号：US08518406B2
公开(公告)日：2013-08-27
申请号：US12544319
申请日：2009-08-20
申请人： Holger Cynis , Hans-Ulrich Demuth , Jens-Ulrich Rahfeld , Kathrin Gans , Stephan Schilling , Sonja Kampfer
发明人： Holger Cynis , Hans-Ulrich Demuth , Jens-Ulrich Rahfeld , Kathrin Gans , Stephan Schilling , Sonja Kampfer
IPC分类号： A61K39/395 , A61K39/44 , C07K16/24
CPC分类号： C07K16/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , G01N33/6854
摘要： Monoclonal antibodies which bind specifically to the proinflammatory cytokine pyroglutamate MCP-1 (MCP-1 N1pE) are described.
摘要翻译： 描述了特异性结合促炎细胞因子焦谷氨酸MCP-1（MCP-1 N1pE）的单克隆抗体。
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公开(公告)号：US20100125086A1
公开(公告)日：2010-05-20
申请号：US12554584
申请日：2009-09-04
申请人： Hans-Ulrich Demuth , Stephan Schilling , Michael Wermann , Holger Cynis , Astrid Kehlen , Daniel Friedrich , Torsten Hoffmann , Kathrin Gans , Jens-Ulrich Rahfeld , Ulrich Heiser , Michael Almstetter , Robert Sommer , Ulf-Torsten Gaertner , Antje Hamann , Michael Thormann , Andreas Tremel
发明人： Hans-Ulrich Demuth , Stephan Schilling , Michael Wermann , Holger Cynis , Astrid Kehlen , Daniel Friedrich , Torsten Hoffmann , Kathrin Gans , Jens-Ulrich Rahfeld , Ulrich Heiser , Michael Almstetter , Robert Sommer , Ulf-Torsten Gaertner , Antje Hamann , Michael Thormann , Andreas Tremel
IPC分类号： A61K31/4178 , C12Q1/25 , A61K31/437 , A61K31/433 , A61K31/4184 , A61P29/00
CPC分类号： C07D233/54 , C07D233/61 , C07D235/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C12N9/104
摘要： The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinising polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.
摘要翻译： 本发明一般涉及谷氨酰胺肽环转移酶样蛋白（QPCTL）的抑制剂及其用于治疗和/或预防炎性疾病或病症的用途，所述炎性疾病或病症选自（a）慢性和急性 炎症，例如 类风湿关节炎，动脉粥样硬化，再狭窄，胰腺炎; （b）其他炎性疾病，例如 神经性疼痛，移植物排斥/移植物衰竭/移植物血管病变，HIV感染/艾滋病，睾丸炎，结节性硬化症，吉兰巴利综合征，慢性炎症性脱髓鞘性多发性神经病和多发性硬化症; （c）神经炎症; 和（d）神经变性疾病，例如 轻度认知障碍（MCI），阿尔茨海默氏症，唐氏综合征神经变性，家族性英国痴呆和家族性丹麦痴呆，可能由神经炎症引起。
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4.发明授权Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions 有权使用isoQC抑制剂治疗和预防炎性疾病或病症公开(公告)号：US08889709B2
公开(公告)日：2014-11-18
申请号：US12554584
申请日：2009-09-04
申请人： Hans-Ulrich Demuth , Stephan Schilling , Michael Wermann , Holger Cynis , Astrid Kehlen , Daniel Friedrich , Torsten Hoffmann , Kathrin Gans , Jens-Ulrich Rahfeld , Ulrich Heiser , Michael Almstetter , Robert Sommer , Ulf-Torsten Gaertner , Antje Hamann , Michael Thormann , Andreas Treml
发明人： Hans-Ulrich Demuth , Stephan Schilling , Michael Wermann , Holger Cynis , Astrid Kehlen , Daniel Friedrich , Torsten Hoffmann , Kathrin Gans , Jens-Ulrich Rahfeld , Ulrich Heiser , Michael Almstetter , Robert Sommer , Ulf-Torsten Gaertner , Antje Hamann , Michael Thormann , Andreas Treml
IPC分类号： A01N43/42 , C12N9/00 , C12N9/10 , C12N1/20 , C12N15/00 , C07H21/04 , C07D417/12 , C07D405/12 , C07D233/61 , C07D409/12 , C07D403/12 , C07D413/12 , C07D403/06 , C07D401/12 , C07D233/54 , C07D235/06
CPC分类号： C07D233/54 , C07D233/61 , C07D235/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C12N9/104
摘要： The present invention relates in general to an inhibitor of a glutaminyl peptide cyclotransferase-like protein (QPCTL), and the use thereof for the treatment and/or prevention of an inflammatory disease or disorder selected from the group consisting of (a) chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis; (b) other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis, Guillain-Barré syndrome, chronic inflammatory demyelinizing polyradiculoneuropathy and multiple sclerosis; (c) neuroinflammation; and (d) neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, and Familial Danish Dementia, which may result from neuroinflammation.
摘要翻译： 本发明一般涉及谷氨酰胺肽环转移酶样蛋白（QPCTL）的抑制剂及其用于治疗和/或预防炎性疾病或病症的用途，所述炎性疾病或病症选自（a）慢性和急性 炎症，例如 类风湿关节炎，动脉粥样硬化，再狭窄，胰腺炎; （b）其他炎性疾病，例如 艾滋病，睾丸炎，结节性硬化症，吉兰巴利综合征，慢性炎性脱髓鞘性多发性神经系统疾病和多发性硬化; （c）神经炎症; 和（d）神经变性疾病，例如 轻度认知障碍（MCI），阿尔茨海默氏症，唐氏综合征神经变性，家族性英国痴呆和家族性丹麦痴呆，可能由神经炎症引起。
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5.发明申请ANTIBODIES DIRECTED AGAINST PYROGLUTAMATE MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1 N1pE) 有权抗吡虫啉单体化合物蛋白-1（MCP-1 N1pE）的抗体公开(公告)号：US20100119478A1
公开(公告)日：2010-05-13
申请号：US12544319
申请日：2009-08-20
申请人： Holger Cynis , Hans-Ulrich Demuth , Jens-Ulrich Rahfeld , Kathrin Gans , Stephen Schilling , Sonja Kampfer
发明人： Holger Cynis , Hans-Ulrich Demuth , Jens-Ulrich Rahfeld , Kathrin Gans , Stephen Schilling , Sonja Kampfer
IPC分类号： A61K39/395 , C07K16/24 , C12N5/16 , A61K38/21 , G01N33/53 , C12N15/13 , A61P35/04 , A61P9/12 , A61P29/00
CPC分类号： C07K16/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92 , G01N33/6854
摘要： Monoclonal antibodies which bind specifically to the proinflammatory cytokine pyroglutamate MCP-1 (MCP-1 N1pE) are described.
摘要翻译： 描述了特异性结合促炎细胞因子焦谷氨酸MCP-1（MCP-1 N1pE）的单克隆抗体。
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公开(公告)号：US20100021478A1
公开(公告)日：2010-01-28
申请号：US12500940
申请日：2009-07-10
申请人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Kathrin Gans , Anita Reisenauer-Schaupp , Jens-Ulrich Rahfeld , Sonja Kampfer
发明人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Kathrin Gans , Anita Reisenauer-Schaupp , Jens-Ulrich Rahfeld , Sonja Kampfer
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821 , G01N2800/387
摘要： The present invention pertains to novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.
摘要翻译： 本发明涉及用于诊断淀粉样变性，特别是阿尔茨海默病的新型诊断测定法和相关方面。 特别地，提供单克隆抗体和抗体测定。
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7.发明授权Antibodies specific for N-terminal truncated and pyroglutamate modified amyloid-beta peptides 有权对N-末端截短和焦谷氨酸修饰的淀粉样蛋白-β肽具有特异性的抗体公开(公告)号：US08058405B2
公开(公告)日：2011-11-15
申请号：US12500940
申请日：2009-07-10
申请人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Kathrin Gans , Anita Reisenauer-Schaupp , Jens-Ulrich Rahfeld , Sonja Kampfer
发明人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Kathrin Gans , Anita Reisenauer-Schaupp , Jens-Ulrich Rahfeld , Sonja Kampfer
IPC分类号： C07K16/18 , C12N5/20 , C12P21/08 , A61K39/395 , G01N33/53
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821 , G01N2800/387
摘要： The present invention pertains to novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.
摘要翻译： 本发明涉及用于诊断淀粉样变性，特别是阿尔茨海默病的新型诊断测定法和相关方面。 特别地，提供单克隆抗体和抗体测定。
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公开(公告)号：US20120064547A1
公开(公告)日：2012-03-15
申请号：US13252929
申请日：2011-10-04
申请人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Kathrin Gans , Anita Reisenauer-Schaupp , Jens-Ulrich Rahfeld , Sonja Kampfer
发明人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Kathrin Gans , Anita Reisenauer-Schaupp , Jens-Ulrich Rahfeld , Sonja Kampfer
IPC分类号： G01N33/566 , G01N33/577
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821 , G01N2800/387
摘要： Novel diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.
摘要翻译： 用于诊断淀粉样变性，特别是阿尔茨海默病的新型诊断测定法和相关方面。 特别地，提供单克隆抗体和抗体测定。
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公开(公告)号：US09156907B2
公开(公告)日：2015-10-13
申请号：US13252929
申请日：2011-10-04
申请人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Kathrin Gans , Anita Reisenauer-Schaupp , Jens-Ulrich Rahfeld , Sonja Kampfer
发明人： Hans-Ulrich Demuth , Stephan Schilling , Martin Kleinschmidt , Kathrin Gans , Anita Reisenauer-Schaupp , Jens-Ulrich Rahfeld , Sonja Kampfer
IPC分类号： G01N33/577 , G01N33/532 , G01N33/543 , C07K16/18 , G01N33/68
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/92 , G01N33/6896 , G01N2333/4709 , G01N2800/2814 , G01N2800/2821 , G01N2800/387
摘要： Diagnostic assays for the diagnosis of amyloidosis, in particular, Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.
摘要翻译： 用于诊断淀粉样变性的诊断测定法，特别是阿尔茨海默氏病和相关方面。 特别地，提供单克隆抗体和抗体测定。
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公开(公告)号：US20100009337A1
公开(公告)日：2010-01-14
申请号：US12497082
申请日：2009-07-02
IPC分类号： C12Q1/00
CPC分类号： C12N9/104 , C07D233/54 , C07D233/61 , C07D235/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes.
摘要翻译： 作为谷氨酰胺环化酶同功酶（QC，EC 2.3.2.5）的新型谷氨酰胺肽 - 转移酶样蛋白（QPCTL），以及编码这些同工酶的分离的核酸，所有这些都可用于发现新的治疗剂， 用于测定环化酶活性，以及测定化合物对这些谷氨酰胺环化酶同工酶的抑制活性。
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