公开(公告)号：US20170183416A1

公开(公告)日：2017-06-29

申请号：US15363103

申请日：2016-11-29

Applicant: SEOUL NATIONAL UNIVERSITY ,  UNIVERSITY OF ULSAN ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PHARSOGEN

Inventor： Youngro Byun ,  In San Kim ,  Ahmed Al-Hilal Taslim ,  Sang-Yoon Kim ,  Ye Ji Jang

IPC: C07K16/28 ,  G01N33/574 ,  G01N33/68 ,  A61K31/727

CPC classification number: C07K16/2872 ,  A61K31/727 ,  A61K39/3955 ,  A61K47/554 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/14 ,  C07K2317/73 ,  C07K2317/76 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/3515 ,  G01N33/57492 ,  G01N33/6893 ,  G01N2333/705

Abstract: Described herein are doppel-targeting molecules useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.