公开(公告)号：US12122830B1

公开(公告)日：2024-10-22

申请号：US17057646

申请日：2019-05-23

申请人： ABL Bio Inc.

发明人： Yangsoon Lee ,  Juhee Kim ,  Kyungjin Park ,  Donghoon Yeom ,  Kyeongsu Park ,  Hyejin Chung ,  Yeunju Kim ,  Eunyoung Park ,  Ui-Jung Jung ,  Eunsil Sung ,  Jinhyung Ahn ,  Byungje Sung ,  Daehae Song ,  Youngdon Pak

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  G01N33/574

CPC分类号： C07K16/2803 ,  A61P35/00 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  G01N2333/705 ,  G01N2333/912

摘要： The present invention discloses an anti-ROR1 antibody specifically recognizing human and mouse ROR1. The monoclonal antibody can be usefully used for cancer targeting treatment including detection of various cancer expressing ROR1 through specific binding, and drug delivery to specific cancer, etc. as well as a cancer therapeutic agent, by inhibiting tumors.

公开(公告)号：US12105096B2

公开(公告)日：2024-10-01

申请号：US16998444

申请日：2020-08-20

申请人： Roche Diagnostics Operations, Inc.

发明人： Martin Hund ,  Thomas Dieterle ,  Olav Lapaire

IPC分类号： G01N33/68

CPC分类号： G01N33/689 ,  G01N33/6863 ,  G01N2333/515 ,  G01N2333/705 ,  G01N2333/91205 ,  G01N2800/368 ,  G01N2800/50

摘要： The present invention is directed to a method for predicting the risk of a female subject to develop postpartum HELLP syndrome, postpartum preeclampsia, or postpartum eclampsia. The method is based on the determination of the levels of i) sFlt-1 and PlGF, or ii) Endoglin and PlGF in a first sample obtained from said subject before delivery of baby, and a second sample of from said subject obtained after delivery of baby. Moreover, encompassed by the invention are devices and kits for carrying out the method of the present invention.

公开(公告)号：US12084498B2

公开(公告)日：2024-09-10

申请号：US17388052

申请日：2021-07-29

申请人： INNATE PHARMA

发明人： Cécile Bonnafous ,  Hélène Sicard ,  Renaud Buffet

IPC分类号： C07K16/28 ,  A61K39/00 ,  C07K16/30 ,  G01N33/574

CPC分类号： C07K16/2803 ,  C07K16/3023 ,  C07K16/3061 ,  G01N33/57426 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/732 ,  G01N2333/705 ,  G01N2333/70503

摘要： The present invention relates to methods for the treatment, prevention and diagnosis of peripheral T cell lymphoma using compounds that specifically bind KIR3DL2. The invention also relates to use of antibodies that specifically bind KIR3DL2 in diagnostic and theranostic assays in the detection and treatment of peripheral T cell lymphoma.

公开(公告)号：US20240239903A1

公开(公告)日：2024-07-18

申请号：US18409571

申请日：2024-01-10

申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Linda DONNELLY ,  Xiaofeng QI ,  Xiaochun LI

IPC分类号： C07K16/28 ,  A61K45/06 ,  G01N33/68

CPC分类号： C07K16/2863 ,  A61K45/06 ,  G01N33/6893 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/76 ,  G01N2333/705 ,  G01N2800/7057

摘要： Disclosures herein are directed to antibodies and epitope binding agents that specifically bind to the extracellular domain of Patched-1 and compositions thereof for use in clinical and non-clinical applications. Also provided are methods to treat and/or prevent Hedgehog pathway related disorders.

公开(公告)号：US12029717B2

公开(公告)日：2024-07-09

申请号：US17345572

申请日：2021-06-11

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER

发明人： Joan Massague ,  Adrienne Boire ,  Qing Chen

IPC分类号： A61K31/352 ,  A61K31/196 ,  A61K31/282 ,  A61K31/555 ,  A61K31/7105 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  G01N33/50

CPC分类号： A61K31/352 ,  A61K31/196 ,  A61K31/282 ,  A61K31/555 ,  A61K31/7105 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  G01N33/5011 ,  G01N2333/705 ,  A61K31/196 ,  A61K2300/00 ,  A61K31/352 ,  A61K2300/00 ,  A61K31/555 ,  A61K2300/00 ,  A61K31/7105 ,  A61K2300/00

摘要： The present invention relates to methods for treating brain metastasis by inhibiting gap junction functionality. It is based, at least in part, on the discovery that cancer cells expressing Protocadherin 7 and Connexin 43 form gap junctions with astrocytes that promote the growth of brain metastases, and that inhibition of Protocadherin 7 and/or Connexin 43 expression in cancer cells reduce progression of brain metastases. It is further based on the discovery that treatment with gap junction inhibitors tonabersat and meclofenamate inhibited progression of brain metastatic lesions and enhanced the anti-cancer activity of the conventional chemotherapeutic agent, carboplatin.

公开(公告)号：US20240150838A1

公开(公告)日：2024-05-09

申请号：US18549333

申请日：2022-03-02

申请人： Ushio Denki Kabushiki Kaisha

发明人： Shun SHIMADA

IPC分类号： C12Q1/6883 ,  C12N5/071 ,  C12N13/00 ,  C12Q1/6874 ,  G01N33/68

CPC分类号： C12Q1/6883 ,  C12N5/0629 ,  C12N13/00 ,  C12Q1/6874 ,  G01N33/6893 ,  G01N2333/705

摘要： Provided is a method capable of efficiently preparing a photoaged cell. Also provided is a novel cell marker that can be used for detection, quantification, or sorting out of a photoaged cell. The present disclosure includes a method for preparing a photoaged cell, including the step of: irradiating a cell with light having an emission peak within a wavelength range of 300 to 315 nm, and a method for detecting or quantifying a photoaged cell, including the step of: detecting or quantifying expression of at least one gene selected from the group consisting of GPR17, CD34, GABRR1, OR2AG2, CMKLR1, CDH19, CD93, AVPR2, CCR7, and OXGR1 in a cell.

公开(公告)号：US20240141036A1

公开(公告)日：2024-05-02

申请号：US18413322

申请日：2024-01-16

申请人： Good T Cells, Inc.

发明人： Jung Ho Kim ,  Beom Seok Kim

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P25/28 ,  C07K14/725 ,  G01N33/68

CPC分类号： C07K16/28 ,  A61K47/6849 ,  A61P25/28 ,  C07K14/7051 ,  G01N33/6848 ,  G01N33/6878 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2319/30 ,  G01N2333/705

摘要： The present invention relates to an epitope of Lrig1 (leucine-rich and immunoglobulin-like domains protein 1) protein, which is an antigen present on the surface of regulatory T cells, and to an antibody or an antigen-binding fragment that specifically binds thereto.

公开(公告)号：US11967222B2

公开(公告)日：2024-04-23

申请号：US17649922

申请日：2022-02-03

申请人： Google LLC

发明人： Jesse William Boettcher ,  Sophie Solveig Le Guen ,  Jason Rundle Rukes ,  Ted Stephen Boda ,  David Sloo

IPC分类号： G08B29/18 ,  A01N1/02 ,  C07K14/705 ,  C12N5/00 ,  C12N5/071 ,  C12N15/85 ,  G01N33/50 ,  G05B15/02 ,  G08B13/00 ,  G08B13/196 ,  G08B25/00 ,  G08B25/08

CPC分类号： G08B29/185 ,  A01N1/021 ,  A01N1/0284 ,  C07K14/705 ,  C12N5/00 ,  C12N5/067 ,  C12N5/069 ,  C12N15/85 ,  G01N33/5008 ,  G05B15/02 ,  G08B13/00 ,  G08B13/196 ,  G08B25/001 ,  G08B25/08 ,  C12N2510/00 ,  G01N2333/705 ,  G05B2219/2642

摘要： A method performed at a computer system includes: obtaining door lock activation data for a door of a dwelling of the user; obtaining current occupancy data for the dwelling; setting a configuration of a controller for the dwelling, based at least in part on the door lock activation data for the door and the current occupancy data for the dwelling; the first configuration including for each sensor in a set of sensors coupled to the controller, disabling the sensor or disabling alerts from the sensor.

公开(公告)号：US11899024B2

公开(公告)日：2024-02-13

申请号：US16629000

申请日：2018-07-12

申请人： Exosome Diagnostics, Inc.

发明人： Mia Sher ,  Erez Eitan ,  Christine Coticchia ,  Johan Karl Olov Skog ,  Robert Kitchen ,  Seth Yu

IPC分类号： G01N33/68 ,  G01N33/537 ,  C12N15/10

CPC分类号： G01N33/6896 ,  C12N15/1013 ,  G01N33/537 ,  G01N2333/705 ,  G01N2800/28

摘要： The invention relates generally to a process for isolating subpopulations of EVs to identify biomarkers useful identifying, determining the progression of, and/or prognosing a disease, including a neurological disease. More particularly, the present invention relates to detection technology of various exosomal biomarkers including proteins, protein modifications, sugars, RNA, DNA, lipids, and metabolites, and combinations thereof.

公开(公告)号：US20240012006A1

公开(公告)日：2024-01-11

申请号：US18044511

申请日：2021-09-20

申请人： The Provost, Fellows, Foundation Scholars, & The Other Members of Board, Of The College Of The Holy

发明人： Vincent KELLY ,  Jill BROWNING ,  William JAGOE

IPC分类号： G01N33/68 ,  G01N33/483

CPC分类号： G01N33/689 ,  G01N33/4833 ,  G01N2800/367 ,  G01N2333/705

摘要： The present invention relates to a method of evaluating sperm health and identifying sperm to be used in Assisted Reproductive Technologies by providing a biological sample from a patient, preferably a semen sample; measuring the quantitative level of a biomarker in the sample; and evaluating sperm health based on the quantitative level of the biomarker, wherein the biomarker is membrane-bound receptor for advanced glycation end products (mRAGE).