公开(公告)号：US09018231B2

公开(公告)日：2015-04-28

申请号：US13520136

申请日：2010-03-24

Applicant: Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Rajesh Kumar Badange ,  Veena Reballi ,  Anil Kashinath Chindhe ,  Rambabu Namala ,  Mohamad Sadik Abdulhamid Mulla ,  Ishtiyaque Ahmad ,  Renny Abraham ,  Venkateswarlu Jasti

Inventor： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Rajesh Kumar Badange ,  Veena Reballi ,  Anil Kashinath Chindhe ,  Rambabu Namala ,  Mohamad Sadik Abdulhamid Mulla ,  Ishtiyaque Ahmad ,  Renny Abraham ,  Venkateswarlu Jasti

IPC: C07D401/12 ,  A61K31/4468 ,  A61P25/18 ,  A61P25/28 ,  C07D211/58 ,  C07D401/14 ,  A61K31/4709 ,  A61K31/4725

CPC classification number: C07D211/58 ,  A61K31/4468 ,  A61K31/4709 ,  A61K31/4725 ,  C07D401/12 ,  C07D401/14

Abstract: The present invention relates to novel sulfone compounds as 5-HT6 receptor ligands of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them.These compounds are useful in the treatment/prevention of various disorders that are related to 5-HT6 receptor functions.

Abstract translation: 本发明涉及作为式（I）的5-HT6受体配体的新型砜化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物 。 本发明还涉及制备上述新化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物的方法。 这些化合物可用于治疗/预防与5-HT 6受体功能相关的各种疾病。

公开(公告)号：US20130005709A1

公开(公告)日：2013-01-03

申请号：US13520136

申请日：2010-03-24

Applicant: Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Rajesh Kumar Badange ,  Veena Reballi ,  Anil Kashinath Chindhe ,  Rambabu Namala ,  Mohamad Sadik Abdulhamid Mulla ,  Ishtiyaque Ahmad ,  Renny Abraham ,  Venkateswarlu Jasti

Inventor： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Rajesh Kumar Badange ,  Veena Reballi ,  Anil Kashinath Chindhe ,  Rambabu Namala ,  Mohamad Sadik Abdulhamid Mulla ,  Ishtiyaque Ahmad ,  Renny Abraham ,  Venkateswarlu Jasti

IPC: A61K31/454 ,  C07D211/58 ,  A61K31/4468 ,  C07D401/14 ,  A61P25/18 ,  A61K31/4725 ,  A61K31/55 ,  A61P25/28 ,  A61P25/24 ,  C07D401/12 ,  A61K31/4709

CPC classification number: C07D211/58 ,  A61K31/4468 ,  A61K31/4709 ,  A61K31/4725 ,  C07D401/12 ,  C07D401/14

Abstract: The present invention relates to novel sulfone compounds as 5-HT6 receptor ligands of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them.These compounds are useful in the treatment/prevention of various disorders that are related to 5-HT6 receptor functions.

Abstract translation: 本发明涉及作为式（I）的5-HT6受体配体的新型砜化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物 。 本发明还涉及制备上述新化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物的方法。 这些化合物可用于治疗/预防与5-HT 6受体功能相关的各种疾病。