公开(公告)号：US09018231B2

公开(公告)日：2015-04-28

申请号：US13520136

申请日：2010-03-24

申请人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Rajesh Kumar Badange ,  Veena Reballi ,  Anil Kashinath Chindhe ,  Rambabu Namala ,  Mohamad Sadik Abdulhamid Mulla ,  Ishtiyaque Ahmad ,  Renny Abraham ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Rajesh Kumar Badange ,  Veena Reballi ,  Anil Kashinath Chindhe ,  Rambabu Namala ,  Mohamad Sadik Abdulhamid Mulla ,  Ishtiyaque Ahmad ,  Renny Abraham ,  Venkateswarlu Jasti

IPC分类号： C07D401/12 ,  A61K31/4468 ,  A61P25/18 ,  A61P25/28 ,  C07D211/58 ,  C07D401/14 ,  A61K31/4709 ,  A61K31/4725

CPC分类号： C07D211/58 ,  A61K31/4468 ,  A61K31/4709 ,  A61K31/4725 ,  C07D401/12 ,  C07D401/14

摘要： The present invention relates to novel sulfone compounds as 5-HT6 receptor ligands of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them.These compounds are useful in the treatment/prevention of various disorders that are related to 5-HT6 receptor functions.

摘要翻译： 本发明涉及作为式（I）的5-HT6受体配体的新型砜化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物 。 本发明还涉及制备上述新化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物的方法。 这些化合物可用于治疗/预防与5-HT 6受体功能相关的各种疾病。

公开(公告)号：US20140148440A1

公开(公告)日：2014-05-29

申请号：US13818152

申请日：2010-11-15

申请人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Rambabu Namala ,  Adi Reddy Dwarampudi ,  Laxman Kota ,  Murlimohan Gampa ,  Padmavathi Kodru ,  Taraka Naga Vinaykumar Tiriveedhi ,  Vishwottam Nagaraj Kandikere ,  Nageshwara Rao Muddana ,  Ramanatha Shrikantha Saralaya ,  Pradeep Jayarajan ,  Dhanalakshmi Shanmuganathan ,  Ishtiyaque Ahmad ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Rambabu Namala ,  Adi Reddy Dwarampudi ,  Laxman Kota ,  Murlimohan Gampa ,  Padmavathi Kodru ,  Taraka Naga Vinaykumar Tiriveedhi ,  Vishwottam Nagaraj Kandikere ,  Nageshwara Rao Muddana ,  Ramanatha Shrikantha Saralaya ,  Pradeep Jayarajan ,  Dhanalakshmi Shanmuganathan ,  Ishtiyaque Ahmad ,  Venkateswarlu Jasti

IPC分类号： C07D513/04 ,  C07D417/12

CPC分类号： C07D513/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

摘要： The present invention relates to heterocyclyl compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to Histamine H3 receptors, for example cognitive disorders, sleep disorders, obesity and pain.

摘要翻译： 本发明涉及式（I）的杂环基化合物及其药学上可接受的盐和组合物。 本发明还涉及制备上述新化合物及其药学上可接受的盐的方法。 式（I）化合物可用于治疗与组胺H3受体相关的各种疾病，例如认知障碍，睡眠障碍，肥胖症和疼痛。

公开(公告)号：US20130005709A1

公开(公告)日：2013-01-03

申请号：US13520136

申请日：2010-03-24

申请人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Rajesh Kumar Badange ,  Veena Reballi ,  Anil Kashinath Chindhe ,  Rambabu Namala ,  Mohamad Sadik Abdulhamid Mulla ,  Ishtiyaque Ahmad ,  Renny Abraham ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Rama Sastri Kambhampati ,  Rajesh Kumar Badange ,  Veena Reballi ,  Anil Kashinath Chindhe ,  Rambabu Namala ,  Mohamad Sadik Abdulhamid Mulla ,  Ishtiyaque Ahmad ,  Renny Abraham ,  Venkateswarlu Jasti

IPC分类号： A61K31/454 ,  C07D211/58 ,  A61K31/4468 ,  C07D401/14 ,  A61P25/18 ,  A61K31/4725 ,  A61K31/55 ,  A61P25/28 ,  A61P25/24 ,  C07D401/12 ,  A61K31/4709

CPC分类号： C07D211/58 ,  A61K31/4468 ,  A61K31/4709 ,  A61K31/4725 ,  C07D401/12 ,  C07D401/14

摘要： The present invention relates to novel sulfone compounds as 5-HT6 receptor ligands of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them.These compounds are useful in the treatment/prevention of various disorders that are related to 5-HT6 receptor functions.

摘要翻译： 本发明涉及作为式（I）的5-HT6受体配体的新型砜化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物 。 本发明还涉及制备上述新化合物及其衍生物，前体药物，互变异构体，立体异构体，多晶型物，溶剂合物，水合物，代谢物，N-氧化物，药学上可接受的盐和含有它们的组合物的方法。 这些化合物可用于治疗/预防与5-HT 6受体功能相关的各种疾病。

公开(公告)号：US08912179B2

公开(公告)日：2014-12-16

申请号：US13818152

申请日：2010-11-15

申请人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Rambabu Namala ,  Adi Reddy Dwarampudi ,  Laxman Kota ,  Murlimohan Gampa ,  Padmavathi Kodru ,  Taraka Naga Vinaykumar Tiriveedhi ,  Vishwottam Nagaraj Kandikere ,  Nageshwara Rao Muddana ,  Ramanatha Shrikantha Saralaya ,  Pradeep Jayarajan ,  Dhanalakshmi Shanmuganathan ,  Ishtiyaque Ahmad ,  Venkateswarlu Jasti

发明人： Ramakrishna Nirogi ,  Anil Karbhari Shinde ,  Ramasastri Kambhampati ,  Rambabu Namala ,  Adi Reddy Dwarampudi ,  Laxman Kota ,  Murlimohan Gampa ,  Padmavathi Kodru ,  Taraka Naga Vinaykumar Tiriveedhi ,  Vishwottam Nagaraj Kandikere ,  Nageshwara Rao Muddana ,  Ramanatha Shrikantha Saralaya ,  Pradeep Jayarajan ,  Dhanalakshmi Shanmuganathan ,  Ishtiyaque Ahmad ,  Venkateswarlu Jasti

IPC分类号： A61K31/535 ,  A61K31/55 ,  C07D513/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

CPC分类号： C07D513/04 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

摘要： The present invention relates to heterocyclyl compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to Histamine H3 receptors, for example cognitive disorders, sleep disorders, obesity and pain.

摘要翻译： 本发明涉及式（I）的杂环基化合物及其药学上可接受的盐和组合物。 本发明还涉及制备上述新化合物及其药学上可接受的盐的方法。 式（I）化合物可用于治疗与组胺H3受体相关的各种疾病，例如认知障碍，睡眠障碍，肥胖症和疼痛。