SYSTEMS AND METHODS FOR MYOPIC ESTIMATION OF NUCLEIC ACID BINDING

    公开(公告)号:US20240153582A1

    公开(公告)日:2024-05-09

    申请号:US17940838

    申请日:2022-09-08

    IPC分类号: G16B30/00

    CPC分类号: G16B30/00

    摘要: Systems and methods for capturing desired interactions and non-interactions of a set of strands (e.g., DNA strands, RNA strands) that may be used in various technological applications, including DNA molecular probes used in medical diagnostics, forensics, microbial ecology, molecular computation, DNA origami, and numerous other applications. Given a nucleic acid system with a certain defined binding pattern, the implementations of the present disclosure automatically generate nucleotide sequences that achieve the intended binding pattern and not other binding patterns, subject to miscellaneous other constraints of the system. Advantageously, given nucleotides i and j, the implementations of the present disclosure consider the binding behavior only in a limited neighborhood of nucleotides surrounding each nucleotide in their respective strands, rather than the binding behavior of whole assignment of which they are a part. These features provide a time-efficient and incremental algorithm that is suitable for numerous practical applications.

    Transactional file system
    2.
    发明授权
    Transactional file system 有权
    事务文件系统

    公开(公告)号:US08510336B2

    公开(公告)日:2013-08-13

    申请号:US13181703

    申请日:2011-07-13

    IPC分类号: G06F17/30

    摘要: A transactional file system wherein multiple file system operations may be performed as a transaction. An application specifies that file system-related operations are to be handled as a transaction, and the application is given a file handle associated with a transaction context. For file system requests associated with a transaction context, a file system component manages operations consistent with transactional behavior. Logging and recovery are also facilitated by logging page data separate from the main log with a unique signature that enables the log to determine whether a page was fully flushed to disk prior to a system crash.

    摘要翻译: 一种事务文件系统,其中可以执行多个文件系统操作作为事务。 应用程序指定文件系统相关操作将作为一个事务来处理,并且应用程序被赋予与事务上下文相关联的文件句柄。 对于与事务上下文相关联的文件系统请求,文件系统组件管理与事务行为一致的操作。 通过使用独特的签名将与主日志分开的页面数据记录在一起,从而使日志能够在系统崩溃之前确定页面是否完全刷新到磁盘,从而方便了日志记录和恢复。

    Central console for monitoring configuration status for remote devices
    3.
    发明授权
    Central console for monitoring configuration status for remote devices 有权
    用于监视远程设备的配置状态的中央控制台

    公开(公告)号:US07509678B2

    公开(公告)日:2009-03-24

    申请号:US11031253

    申请日:2005-01-07

    IPC分类号: G06F12/14 G06B23/00

    CPC分类号: H04L67/02 H04L63/12

    摘要: The present invention allows for remotely and securely configuring settings for targeted devices within a network with multiple security-trust boundaries. Configuration information is encoded in messages that are digitally signed to ensure the integrity of the configuration information and sent in accordance with a standard messaging transport protocol. By utilizing an already existing port of the standard messaging transport protocol, e.g., SMTP, the number of open ports for configuration purposes is minimized. Further, example embodiments take advantage of hidden fields, i.e., machine readable fields that contain metadata that by default are not presented at a client user interface, for encoding the configuration or command/control information within the messages. The present invention further provides for a central console module that can manage and report on the status of the configuration settings for a plurality of targeted devices that an authorized user or system administrator has attempted to remotely configure.

    摘要翻译: 本发明允许远程和安全地配置具有多个安全 - 信任边界的网络内的目标设备的设置。 配置信息被编码在经数字签名的消息中,以确保配置信息的完整性并根据标准消息传送协议发送。 通过利用标准消息传送协议(例如SMTP)的现有端口,用于配置目的的开放端口的数量被最小化。 此外,示例实施例利用隐藏字段,即,包含默认情况下不在客户端用户界面呈现的元数据的机器可读字段,用于对消息内的配置或命令/控制信息进行编码。 本发明还提供了一种中央控制台模块,其可以管理和报告授权用户或系统管理员已尝试远程配置的多个目标设备的配置设置的状态。

    Systems and methods that determine intent of data and respond to the data based on the intent
    4.
    发明授权
    Systems and methods that determine intent of data and respond to the data based on the intent 有权
    确定数据意图并根据意图响应数据的系统和方法

    公开(公告)号:US07496500B2

    公开(公告)日:2009-02-24

    申请号:US10867626

    申请日:2004-06-15

    CPC分类号: G06Q10/107

    摘要: The present invention relates to systems and methods that determine intent for received data (e.g., email, voice, graphics . . . ) and respond to the data based on the intent. The systems and methods employ various combinations of features based on shallow and deep linguistic analysis (e.g., semantic and syntactic) to yield very high accuracy. The systems and methods analyze and categorize received data to locate data that can include intent. This data can be further refined by extracting features related to the intent. The features can be utilized by a classifier to determine the intent. If the intent warrants a response, the data are further scrutinized and reformulated to generate a description that is indicative of the intent. The reformulation can include representing the features in a logical form, transforming the form and generating a description of the intent that can be presented to a user visually and/or audibly.

    摘要翻译: 本发明涉及确定接收到的数据(例如,电子邮件,语音,图形...)的意图并基于意图响应数据的系统和方法。 系统和方法采用基于浅层和深层语言分析(例如语义和句法)的特征的各种组合,以产生非常高的精度。 系统和方法分析和分类接收到的数据以定位可包括意图的数据。 可以通过提取与意图相关的特征来进一步改进该数据。 分类器可以利用这些特征来确定意图。 如果意图保证有回应,则会对数据进行仔细检查和重新设计,以生成表示意图的描述。 重新制定可以包括以逻辑形式表示特征,转换形式并生成可以以视觉和/或听觉呈现给用户的意图的描述。

    Enforcing rights management through edge email servers
    5.
    发明授权
    Enforcing rights management through edge email servers 有权
    通过边缘电子邮件服务器实施权限管理

    公开(公告)号:US07454778B2

    公开(公告)日:2008-11-18

    申请号:US10954873

    申请日:2004-09-30

    IPC分类号: H04L9/00 H04L9/32

    CPC分类号: H04L63/102 H04L51/12

    摘要: The present invention provides for methods, systems, and computer program products for ensuring that sensitive subject matter within electronic messages is not inappropriately transferred between domains with differing security rights. The present invention utilizes the appropriate placement of message transfer agents or servers along with policy documents that include configurable semantics pattern recognition data for identifying deviant messages. Once deviant messages or messages that potentially have sensitive subject matter are identified, the present invention further provides for adaptable actions or remedies for ensuring that the sensitive subject matter is not inappropriately transferred between domains.

    摘要翻译: 本发明提供方法,系统和计算机程序产品,用于确保电子消息内的敏感主题不会在具有不同安全权限的域之间不适当地传送。 本发明利用消息传输代理或服务器的适当布置以及包括可配置语义模式识别数据的策略文档,用于识别错误消息。 一旦识别出潜在地具有敏感主题的偏差消息或消息,本发明还提供了用于确保敏感主题在域之间不被不适当地传送的适应性动作或补救措施。

    Transactional file system
    6.
    发明授权
    Transactional file system 有权
    事务文件系统

    公开(公告)号:US06856993B1

    公开(公告)日:2005-02-15

    申请号:US09539233

    申请日:2000-03-30

    IPC分类号: G06F12/00 G06F17/30

    摘要: A transactional file system wherein multiple file system operations may be performed as transaction. An application specifies that file system-related operations should be handled in a transaction, and is given a file handle associated with a transaction context. For file system requests associated with a transaction context, a file system component manages operations consistent with transactional behavior. The component provides data isolation by providing multiple file versions such that transactional readers do not receive changes until after the transaction commits and the reader reopens the file. The component handles namespace logging operations in a multiple-level log that facilitates logging and recovery. Page data is logged separate from the main log, with signatures establishing whether pages were fully flushed to disk. Namespace isolation via isolation directories allows a transaction to see its operational effects but not effects of other uncommitted transactions. Transactions over a network are facilitated.

    摘要翻译: 可以作为事务执行多个文件系统操作的事务文件系统。 一个应用程序指定文件系统相关的操作应该在事务中处理,并且被赋予与事务上下文关联的文件句柄。 对于与事务上下文相关联的文件系统请求,文件系统组件管理与事务行为一致的操作。 该组件通过提供多个文件版本来提供数据隔离,以便在事务提交之后事务读取器不会接收更改,并且读取器重新打开该文件。 该组件处理多级日志中的命名空间日志记录操作,便于记录和恢复。 页面数据与主日志分开记录,签名确定页面是否完全刷新到磁盘。 通过隔离目录命名空间隔离允许事务查看其操作效果,但不影响其他未提交的事务。 通过网络进行的交易是便利的。

    Data transfer utilizing single functionally independent data transfer mechanism
    7.
    发明授权
    Data transfer utilizing single functionally independent data transfer mechanism 失效
    数据传输利用单一功能独立的数据传输机制

    公开(公告)号:US06721951B1

    公开(公告)日:2004-04-13

    申请号:US09258039

    申请日:1999-02-25

    IPC分类号: G06F946

    CPC分类号: G06F9/543

    摘要: An improved data transfer mechanism is provided. In a preferred embodiment of the present invention, a uniform data transfer mechanism is used by each computer program performing data transfer. The uniform data transfer mechanism of the preferred embodiment of the present invention provides a communication mechanism and a flexible and robust interface to support all existing and future data transfer applications.

    摘要翻译: 提供了一种改进的数据传输机制。 在本发明的优选实施例中,每个执行数据传输的计算机程序使用统一的数据传送机制。 本发明的优选实施例的统一数据传输机制提供了一种通信机制以及灵活和可靠的接口,以支持所有现有和将来的数据传输应用。

    Method and system for network marshalling of interface pointers for
remote procedure calls
    10.
    发明授权
    Method and system for network marshalling of interface pointers for remote procedure calls 失效
    用于远程过程调用的接口指针的网络编组方法和系统

    公开(公告)号:US5511197A

    公开(公告)日:1996-04-23

    申请号:US158627

    申请日:1993-11-29

    摘要: A computer method and system for passing a pointer to an interface from a server process to a client process. In a preferred embodiment, the server process instantiates an object that has multiple interfaces. The server process identifies an interface to pass to the client process and creates a stub object for receiving a request to invoke a function member of the interface and for invoking the requested function member upon receiving the request. The server process then sends an identifier of the stub to the client process. When the client process receives the identifier of the stub, it instantiates a proxy object for receiving requests to invoke a function member of the interface and for sending the request to the identified stub. The client process can then invoke the function members of the interface by invoking function members of the proxy object. The proxy object sends a request to the identified stub. The identified stub then invokes the corresponding function member of the interface.

    摘要翻译: 一种用于将指针从服务器进程传递到客户端进程的计算机方法和系统。 在优选实施例中,服务器进程实例化具有多个接口的对象。 服务器进程标识要传递给客户端进程的接口,并创建一个存根对象,用于接收调用接口的功能成员的请求,并在接收到请求时调用所请求的函数成员。 然后,服务器进程将存根的标识符发送到客户端进程。 当客户端进程接收存根的标识符时,它实例化一个代理对象,用于接收请求以调用该接口的一个功能成员,并将该请求发送到已识别的存根。 客户端进程可以通过调用代理对象的函数成员来调用接口的函数成员。 代理对象向已识别的存根发送请求。 识别的存根然后调用接口的相应功能成员。