公开(公告)号：US20140341922A1

公开(公告)日：2014-11-20

申请号：US14360117

申请日：2012-11-23

Applicant: SUN R&DB Foundation

Inventor： Ho Young Lee

IPC: C07K16/28 ,  A61K31/519 ,  G01N33/574 ,  A61K39/395

CPC classification number: C07K16/2848 ,  A61K31/519 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/73 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57492 ,  G01N2800/52 ,  A61K2300/00

Abstract: Provided are a pharmaceutical composition for suppressing a resistance to a targeted anticancer drug, which at least one selected from the group consisting of an integrin β3 neutralizing antibody, integrin β3 siRNA, Src inhibitor, and Src siRNA as an active ingredient, and an anticancer supplement. The pharmaceutical composition may increase an anticancer therapeutic effect when administered in combination with a conventional targeted anticancer drug. In addition, the pharmaceutical composition is expected to be used in development of an integrin β3-targeted targeted anticancer drug.

Abstract translation: 本发明提供了抑制靶向抗癌药物的抗性的药物组合物，其中选自由整联蛋白3中和抗体，整联蛋白3，siRNA，Src抑制剂和Src siRNA作为有效成分组成的组中的至少1种， 和抗癌补品。 当与常规靶向抗癌药物组合施用时，药物组合物可以增加抗癌治疗效果。 此外，药物组合物预期用于开发整合素和靶向靶向抗癌药物。

公开(公告)号：US20150322485A1

公开(公告)日：2015-11-12

申请号：US14650311

申请日：2013-12-09

Applicant: SUN R&DB FOUNDATION

Inventor： Sunghoon KWON ,  Taehoon RYU ,  Yeongjae CHOI ,  Yushin JUNG ,  Hyoki KIM ,  Howon LEE

IPC: C12Q1/68

Abstract: Provided is a method of isolating biochemical molecules on a microarray substrate, the method including providing a microarray substrate to which clusters of different kinds of biochemical molecules being classified by individual spot units are attached, the individual spots being regularly arranged thereon; obtaining location information of the individual spot in which a desired cluster among clusters of the biochemical molecules locates; locating an extraction tool for applying energy to isolate the desired cluster according to the location information; and isolating the desired cluster from the microarray substrate by applying energy in a contact or non-contact manner using the extraction tool.

Abstract translation: 提供了一种在微阵列基板上分离生物化学分子的方法，所述方法包括提供微阵列基板，各个斑点单元分类的不同种类的生化分子的簇被附着到所述微阵列基板上，所述各个斑点被规则地布置在其上; 获取生物化学分子簇之间所需簇的位置信息; 定位用于施加能量的提取工具，以根据所述位置信息隔离所述期望的群集; 并通过使用提取工具以接触或非接触的方式施加能量从微阵列基底分离所需的簇。

公开(公告)号：US20210328766A1

公开(公告)日：2021-10-21

申请号：US17172643

申请日：2021-02-10

Applicant: SAMSUNG ELECTRONICS CO., LTD. ,  SUN R&DB FOUNDATION ,  Industry Academic Cooperation Foundation Chosun University

Inventor： Jong Seon NO ,  Yong Woo LEE ,  Young Sik KIM ,  Joon Woo LEE

IPC: H04L9/00

Abstract: A method and apparatus for processing a ciphertext based on homomorphic encryption. The method includes determining an approximate polynomial corresponding to a modulus reduction for bootstrapping a ciphertext based on samples extracted from the modulus reduction, and bootstrapping the ciphertext based on the approximate polynomial.