公开(公告)号：US09018371B2

公开(公告)日：2015-04-28

申请号：US12530086

申请日：2007-03-07

申请人： Lak Shin Jeong ,  Hea Ok Kim ,  Kenneth A. Jacobson ,  Seung Ah Choe

发明人： Lak Shin Jeong ,  Hea Ok Kim ,  Kenneth A. Jacobson ,  Seung Ah Choe

IPC分类号： C07H19/16 ,  C07H1/00 ,  C07D473/34

CPC分类号： C07D473/34 ,  C07H19/16

摘要： Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A3 adenosine receptors and act as A3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

摘要翻译： 公开了腺苷衍生物，其合成方法和用于预防和治疗炎性疾病的药物组合物，其包含与活性成分相同的物质。 腺苷衍生物对腺苷受体具有高结合亲和力和选择性，特别是A3腺苷受体，作为A3腺苷受体拮抗剂，具有抗炎活性。 因此，腺苷衍生物可用于预防和治疗炎性疾病。

公开(公告)号：US20100137577A1

公开(公告)日：2010-06-03

申请号：US12530086

申请日：2007-03-07

申请人： Lak Shin Jeong ,  Hea Ok Kim ,  Kenneth A. Jacobson ,  Seung Ah Choe

发明人： Lak Shin Jeong ,  Hea Ok Kim ,  Kenneth A. Jacobson ,  Seung Ah Choe

IPC分类号： C07H19/16 ,  C07H1/00

CPC分类号： C07D473/34 ,  C07H19/16

摘要： Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A3 adenosine receptors and act as A3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

摘要翻译： 公开了腺苷衍生物，其合成方法和用于预防和治疗炎性疾病的药物组合物，其包含与活性成分相同的物质。 腺苷衍生物对腺苷受体具有高结合亲和力和选择性，特别是A3腺苷受体，作为A3腺苷受体拮抗剂，具有抗炎活性。 因此，腺苷衍生物可用于预防和治疗炎性疾病。