公开(公告)号：US06608078B2

公开(公告)日：2003-08-19

申请号：US09850669

申请日：2001-05-07

申请人： Noel John De Souza ,  Mahesh Vithalbhai Patel ,  Shiv Kumar Agarwal ,  Shirkant V Gupte ,  Dilip J Upadhyay ,  Satish B Bhawsar ,  Mohammad A Jafri

发明人： Noel John De Souza ,  Mahesh Vithalbhai Patel ,  Shiv Kumar Agarwal ,  Shirkant V Gupte ,  Dilip J Upadhyay ,  Satish B Bhawsar ,  Mohammad A Jafri

IPC分类号： A61K314375

CPC分类号： C07D451/04 ,  A61K45/06

摘要： The present invention relates to optically pure 8-(substituted piperidino)-benzo[i,j]quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to processes for their preparation, and to pharmaceutical compositions comprising 8-(substituted piperidino)-benzo[i,j]quinolizines their isomers, derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions possess potent activity in treating local and systemic infections, particularly infections caused by sensitive and resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and nosocomial pathogens, and particularly those belonging to the staphylococcus, streptococcus and enterococcus groups. Methods for treating the diseases and disorders arising from the foregoing infections in humans and animals are described by administering the compounds of the invention to said humans and animals.