专利检索 ap:"Noel John De Souza" 第 1 页

1.

发明授权
Polymorphs of racemic, dextrorotatory, and levorotatory enantioners of 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid hydrochloride and mesylate salts 有权
标题翻译： 1-环丙基-6-氟-8-甲氧基-7-（4-氨基-3,3-二甲基哌啶-1-基）-1,4-二氢-4-氧代 - 吡咯并[3,2-d] 喹啉-3-羧酸盐酸盐和甲磺酸盐

公开(公告)号：US07538221B2

公开(公告)日：2009-05-26

申请号：US10578371

申请日：2004-11-10

申请人： Prasad Keshav Deshpande , Satish Baliram Bhavsar , Yati Chugh , Ravindra Dattatrya Yeole , Noel John De Souza , Mahesh Vithalbhai Patel

发明人： Prasad Keshav Deshpande , Satish Baliram Bhavsar , Yati Chugh , Ravindra Dattatrya Yeole , Noel John De Souza , Mahesh Vithalbhai Patel

IPC分类号： C07D215/38 , A61K31/44

CPC分类号： C07D401/04

摘要： A polymorphic forms of the hydrochloride salt and mesylate salt of racemic (±)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid, dextrorotatory R-(+)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and S-(−)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid having formula (I) and (II) respectively are described. Processes for their preparation are also described. The invention further relates to methods of using, and pharmaceutical compositions comprising the compounds of the invention for treatment of bacterial infections in mammals.

摘要翻译： 外消旋（±）-1-环丙基-6-氟-8-甲氧基-7-（4-氨基-3,3-二甲基哌啶-1-基）-1,4-苯并二氢吡喃的盐酸盐和甲磺酸盐的多晶形式， -2,3-二氢-4-氧代 - 喹啉-3-羧酸，右旋R - （+）-1-环丙基-6-氟-8-甲氧基-7-（4-氨基-3,3-二甲基哌啶-1-基） - 1,4-二氢-4-氧代 - 喹啉-3-羧酸和S - （ - ） - 1-环丙基-6-氟-8-甲氧基-7-（4-氨基-3,3-二甲基哌啶-1-基）（I）和（II）的1,4-二氢-4-氧代 - 喹啉-3-羧酸。还描述了其制备方法。本发明还涉及包含本发明化合物用于治疗哺乳动物细菌感染的药物组合物的方法和药物组合物。

2.

发明授权
Pharmacologically effective substance from plants belonging to the family of Labiatae 失效
标题翻译：来自Labiatae家族植物的药理学有效物质

公开(公告)号：US4118508A

公开(公告)日：1978-10-03

申请号：US791020

申请日：1977-04-26

申请人： Sujata Vasudev Bhat , Noel John DE Souza , Horst Dornauer , Bani Kanta Bhattacharya , Alihussein Nomanbhai Dohadwalla

发明人： Sujata Vasudev Bhat , Noel John DE Souza , Horst Dornauer , Bani Kanta Bhattacharya , Alihussein Nomanbhai Dohadwalla

IPC分类号： A61K31/35 , A61K31/352 , A61K36/00 , A61K36/53 , A61P9/12 , C07D311/92 , C07G99/00 , C07D311/02

CPC分类号： A61K36/53 , C07D311/92

摘要： This invention relates to a pharmacologically effective substance named Coleforsin, to a process for its preparation from plants belonging to the Labiatae family, and to pharmaceutical preparations containing it.

摘要翻译： 本发明涉及一种名为Coleforsin的药理学有效物质，其用于从属于Labiatae家族的植物制备方法和含有它的药物制剂。

3.

发明授权
Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments 失效
标题翻译：产生三重靶向，手性，广谱抗微生物剂7-取代哌啶子基 - 喹诺酮羧酸衍生物，其制备，组合物和作为药物的用途

公开(公告)号：US07626032B2

公开(公告)日：2009-12-01

申请号：US12150075

申请日：2008-04-24

申请人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla

发明人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla

IPC分类号： C07D211/56

CPC分类号： A61K31/47 , A61K45/06 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , Y10S514/859

摘要： This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

摘要翻译： 本发明涉及新一代三靶向，手性，广谱抗微生物7-取代的哌啶子基 - 喹诺酮羧酸衍生物，其旋光异构体，非对映异构体或对映异构体，以及其药学上可接受的盐，水合物，前药，多晶型物和假多晶型物，准备，组合和使用。

4.

发明授权
Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments 失效
标题翻译：产生三重靶向，手性，广谱抗微生物剂7-取代哌啶子基 - 喹诺酮羧酸衍生物，其制备，组合物和作为药物的用途

公开(公告)号：US07393957B2

公开(公告)日：2008-07-01

申请号：US10945504

申请日：2004-09-20

申请人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla

发明人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla

IPC分类号： C07D215/38 , A61K31/47

CPC分类号： A61K31/47 , A61K45/06 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , Y10S514/859

摘要： This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

摘要翻译： 本发明涉及新一代三靶向，手性，广谱抗微生物7-取代的哌啶子基 - 喹诺酮羧酸衍生物，其旋光异构体，非对映异构体或对映异构体，以及其药学上可接受的盐，水合物，前药，多晶型物和假多晶型物，准备，组合和使用。

5.

发明授权
Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment 失效

公开(公告)号：US06608078B2

公开(公告)日：2003-08-19

申请号：US09850669

申请日：2001-05-07

申请人： Noel John De Souza , Mahesh Vithalbhai Patel , Shiv Kumar Agarwal , Shirkant V Gupte , Dilip J Upadhyay , Satish B Bhawsar , Mohammad A Jafri

发明人： Noel John De Souza , Mahesh Vithalbhai Patel , Shiv Kumar Agarwal , Shirkant V Gupte , Dilip J Upadhyay , Satish B Bhawsar , Mohammad A Jafri

IPC分类号： A61K314375

CPC分类号： C07D451/04 , A61K45/06

摘要： The present invention relates to optically pure 8-(substituted piperidino)-benzo[i,j]quinolizines, their isomers, derivatives, salts, pseudopolymorphs, polymorphs prodrugs and hydrates thereof, to processes for their preparation, and to pharmaceutical compositions comprising 8-(substituted piperidino)-benzo[i,j]quinolizines their isomers, derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof. These compounds and compositions possess potent activity in treating local and systemic infections, particularly infections caused by sensitive and resistant Gram-positive organism infections, Gram-negative organism infections, mycobacterial infections and nosocomial pathogens, and particularly those belonging to the staphylococcus, streptococcus and enterococcus groups. Methods for treating the diseases and disorders arising from the foregoing infections in humans and animals are described by administering the compounds of the invention to said humans and animals.

6.

发明授权
Antibacterial optically pure benzoquinolizine carboxylic acids, processes, compositions and methods of treatment 有权
标题翻译：抗菌光学纯苯喹啉羧酸，方法，组合物和治疗方法

公开(公告)号：US07247642B2

公开(公告)日：2007-07-24

申请号：US09566875

申请日：2000-05-08

申请人： Mahesh Vithalbhai Patel , Shivkumar Agarwal , Sreenivas Kandepu , Nitin Shetty , Dilip Jatashankar Upadhyay , Nishith Chandra Chaturvedi , Abraham Thomas , Noel John De Souza , Habil Fakhruddin Khorakiwala

发明人： Mahesh Vithalbhai Patel , Shivkumar Agarwal , Sreenivas Kandepu , Nitin Shetty , Dilip Jatashankar Upadhyay , Nishith Chandra Chaturvedi , Abraham Thomas , Noel John De Souza , Habil Fakhruddin Khorakiwala

IPC分类号： A61K31/4375 , C07D487/12

CPC分类号： C07C279/14 , A61K31/4745 , C07B2200/07 , C07D455/04 , Y02A50/473

摘要： The present invention relates to optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof, substantially free of their R-(+)-isomers, to processes for preparation of the optically pure S-(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof substantially free of their R-(+)-isomers, and to pharmaceutical compositions comprising the S(−)-benzoquinolizine carboxylic acids, their derivatives, salts, pseudopolymorphs, polymorphs and hydrates thereof.

摘要翻译： 本发明涉及基本上不含其R - （+） - 异构体的光学纯的S - （ - ） - 苯并喹嗪羧酸，其衍生物，盐，假多晶型物，多晶型物和水合物，用于制备光学纯S - （ - ） - 苯并喹嗪羧酸，它们的衍生物，盐，假多晶型物，基本上不含其R - （+） - 异构体的多晶型物和水合物，以及包含S（ - ） - 苯醌喹唑啉羧酸的衍生物，盐，假多晶型物，多晶型物及其水合物。

7.

发明申请
SUBSTITUTED PIPERIDINO PHENYLOXAZOLIDINONES HAVING ANTIMICROBIAL ACTIVITY WITH IMPROVED IN VIVO EFFICACY 有权
标题翻译：具有改善活体功效的抗微生物活性的替代哌啶苯并噻唑啉酮

公开(公告)号：US20100144735A1

公开(公告)日：2010-06-10

申请号：US12705258

申请日：2010-02-12

申请人： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugil , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel

发明人： Prasad Keshav Deshpande , Milind Dattatraya Sindkhedkar , Mahesh Shriram Phansalkar , Ravindra Dattatraya Yeole , Shrikant Vinayak Gupte , Yati Chugil , Nitin Shetty , Sachin Subhash Bhagwat , Milind Chintaman Shukla , Noel John De Souza , Mahesh Vithalbhai Patel

IPC分类号： A61K31/5377 , A61K31/496 , A61K31/438 , A61K31/4545 , A61K31/454 , C07D498/10 , C07D495/10 , C07D491/113 , C07D413/10 , A61P31/04 , C07D491/107 , C07D413/14 , C07D513/10

CPC分类号： C07D491/10 , C07D413/10 , C07D413/14 , C07D495/10 , C07D497/10 , C07D513/10

摘要： The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

摘要翻译： 本发明提供具有预防和治疗感染性疾病的抗微生物活性的试剂。因此，本发明提供新的取代的哌啶子基苯基恶唑烷酮衍生物，制备化合物的方法以及含有所述衍生物作为活性成分的抗微生物组合物以及用所述衍生物治疗细菌感染的方法。

8.

发明申请
New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments 失效
标题翻译：新一代三靶向，手性，广谱抗微生物剂7-取代哌啶子基 - 喹诺酮羧酸衍生物，其制备，组合物和作为药物的用途

公开(公告)号：US20080214608A1

公开(公告)日：2008-09-04

申请号：US12150075

申请日：2008-04-24

申请人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla

发明人： Noel John De Souza , Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Shiv Kumar Agarwal , Kandepu Sreenivas , Sheela Chandrasekharan Nair , Yati Chugh , Milind Chintaman Shukla

IPC分类号： A61K31/4468 , C07D211/58

CPC分类号： A61K31/47 , A61K45/06 , C07D215/233 , C07D401/04 , C07D401/14 , C07D413/12 , C07D455/04 , C07D471/04 , C07D471/08 , Y10S514/859

摘要： This invention relates to new generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, to their optical isomers, diastereomers or enantiomers, as well as pharmaceutically acceptable salts, hydrates, prodrugs, polymorphs and pseudopolymorphs thereof, to their preparation, to their compositions and to their use.

摘要翻译： 本发明涉及新一代三靶向，手性，广谱抗微生物7-取代的哌啶子基 - 喹诺酮羧酸衍生物，其旋光异构体，非对映异构体或对映异构体，以及其药学上可接受的盐，水合物，前药，多晶型物和假多晶型物，准备，组合和使用。