COMPOSITIONS COMPRISING POLYCATION-COMPLEXED PROTEIN CRYSTALS AND METHODS OF TREATMENT USING THEM
    5.
    发明申请
    COMPOSITIONS COMPRISING POLYCATION-COMPLEXED PROTEIN CRYSTALS AND METHODS OF TREATMENT USING THEM 审中-公开
    包含聚合复合蛋白质晶体的组合物和使用它们的治疗方法

    公开(公告)号:US20090023629A1

    公开(公告)日:2009-01-22

    申请号:US12158384

    申请日:2006-12-22

    IPC分类号: A61K38/00 A61P1/00

    摘要: The present invention relates to compositions comprising polycation-complexed protein crystals and hyaluronic acid. Advantageously, the compositions of this invention are stable, long-acting and avoid local reactions at the injection site. Compositions according to this invention include sustained-release human growth hormone compositions. Such compositions are useful for treating a subject having a disorder associated with human growth hormone deficiency or that is ameliorated by human growth hormone therapy.

    摘要翻译: 本发明涉及包含聚阳离子络合蛋白晶体和透明质酸的组合物。 有利地,本发明的组合物是稳定的,长效的并避免在注射部位的局部反应。 根据本发明的组合物包括缓释人生长激素组合物。 这样的组合物可用于治疗患有与人生长激素缺乏相关的疾病或通过人生长激素治疗改善的受试者。