公开(公告)号：US20220409666A1

公开(公告)日：2022-12-29

申请号：US17848313

申请日：2022-06-23

Applicant: The Regents of the University of California ,  The Trustees of Princeton University ,  The Simons Foundation, Inc.

Inventor： Wendell A. Lim ,  Olga G. Troyanskaya ,  Benjamin VanderSluis ,  Ruth Dannenfelser

IPC: A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  A61K38/17 ,  G16Z99/00 ,  A61P35/00 ,  G16B5/20 ,  C07K14/705 ,  C07K16/28

Abstract: The present disclosure provides an immune cell genetically modified to produce two antigen triggered polypeptides, each recognizing a different cell surface antigen. The present disclosure provides a system two antigen-triggered polypeptides, each recognizing a different cell surface antigen. The present disclosure provides a method of killing a target cancer cell, using a genetically modified immune cell or a system of the present disclosure. The present disclosure provides a computational method to identify target N antigen pairs on a cancer cell.

公开(公告)号：US20220127373A1

公开(公告)日：2022-04-28

申请号：US17291794

申请日：2019-11-07

Applicant: The Regents of the University of California ,  The Trustees of Princeton University ,  The Simons Foundation, Inc.

Inventor： Wendell A. Lim ,  Olga G. Troyanskaya ,  Benjamin Vandersluis ,  Ruth Dannenfelser

IPC: C07K16/30 ,  C07K16/40 ,  C07K16/28 ,  A61K35/17 ,  A61P35/00 ,  C07K14/725

Abstract: The present disclosure provides immune cells genetically modified to produce two antigentriggered polypeptides, each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. The present disclosure further provides systems comprising two antigen-triggered polypeptides (or nucleic acids encoding same), each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. Also provided are method of killing a target cancer cell, using the described genetically modified immune cells and/or systems. The present disclosure also provides poly specific-immune inducing polypeptides including first and second antigen binding domains specific for first and second antigens, respectively, present on the surface of a target cancer cell.

公开(公告)号：US20190134093A1

公开(公告)日：2019-05-09

申请号：US16096248

申请日：2017-05-05

Applicant: The Regents of the University of California ,  The Trustees of Princeton University ,  The Simons Foundation, Inc.

Inventor： Wendell A. Lim ,  Olga G. Troyanskaya ,  Benjamin VanderSluis ,  Ruth Dannenfelser

IPC: A61K35/17 ,  C12N5/0783 ,  C07K14/705 ,  C07K14/725 ,  G16B5/20 ,  A61P35/00 ,  C07K16/28

Abstract: The present disclosure provides an immune cell genetically modified to produce two antigentriggered polypeptides, each recognizing a different cell surface antigen. The present disclosure provides a system two antigen-triggered polypeptides, each recognizing a different cell surface antigen. The present disclosure provides a method of killing a target cancer cell, using a genetically modified immune cell or a system of the present disclosure. The present disclosure provides a computational method to identify target antigen pairs on a cancer cell.

公开(公告)号：US20230330142A1

公开(公告)日：2023-10-19

申请号：US18017849

申请日：2021-08-12

Applicant: The Regents of the University of California ,  THE TRUSTEES OF PRINCETON UNIVERSITY ,  THE SIMONS FOUNDATION, INC.

Inventor： Ruth DANNENFELSER ,  Gregory ALLEN ,  Olga G. TROYANSKAYA ,  Wendell A. LIM

IPC: A61K35/17 ,  C07K14/725 ,  A61P35/00

CPC classification number: A61K35/17 ,  C07K14/7051 ,  A61P35/00

Abstract: The present disclosure provides immune cells genetically modified to produce two antigen-triggered polypeptides, each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. The present disclosure further provides systems comprising two antigen-triggered polypeptides (or nucleic acids encoding same), each recognizing a different cell surface antigen, wherein the two different cell surface antigens employed are selected from those pairs described herein. Also provided are method of killing a target cancer cell, using the described genetically modified immune cells and/or systems. The present disclosure also provides polyspecific-immune inducing polypeptides including first and second antigen binding domains specific for first and second antigens, respectively, present on the surface of a target cancer cell.

公开(公告)号：US20240087674A1

公开(公告)日：2024-03-14

申请号：US18513348

申请日：2023-11-17

Applicant: Genentech, Inc. ,  Simons Foundation ,  New York University

Inventor： Vladimir Gligorijevic ,  Richard A. Bonneau ,  Kyunghyun Cho

IPC: G16B15/00 ,  G16B30/20

CPC classification number: G16B15/00 ,  G16B30/20

Abstract: A protein design system includes one or more processors configured to modify, by a modifier, an input sequence corresponding to a protein, the input sequence comprising a data structure indicating a plurality of amino acid residues of the protein; map, by an encoder, the modified sequence to a latent space; predict, by a length predictor, a length difference between the mapped sequence and a target sequence based on at least one target function of the target sequence; identify, by a function classifier, at least one sequence function of the modified sequence; transform, by a length transformer, the modified sequence based on the length difference and the at least one sequence function; and generate, by a decoder, a candidate for the target sequence based on the transformed sequence.

公开(公告)号：US20210027855A1

公开(公告)日：2021-01-28

申请号：US17041836

申请日：2019-03-26

Applicant: The Trustees of Princeton University ,  The Simons Foundation, Inc.

Inventor： Jian Zhou ,  Chandra Theesfeld ,  Olga G. Troyanskaya

IPC: G16B20/20

Abstract: Processes to determine the effect of genetic sequence on gene expression levels are described. Generally, models are used to determine spatial chromatin profile from genetic sequence, which can be used in several downstream applications. The effect of the spatial chromatin profile on gene expression is also determined in some instances. Various methods further develop research tools, perform diagnostics, and treat individuals based on sequence effects on gene expression levels.

公开(公告)号：US12176068B2

公开(公告)日：2024-12-24

申请号：US17041836

申请日：2019-03-26

Applicant: The Trustees of Princeton University ,  The Simons Foundation, Inc.

Inventor： Jian Zhou ,  Chandra Theesfeld ,  Olga G. Troyanskaya

IPC: G16B20/20 ,  G16B20/50 ,  G16B25/10

Abstract: Processes to determine the effect of genetic sequence on gene expression levels are described. Generally, models are used to determine spatial chromatin profile from genetic sequence, which can be used in several downstream applications. The effect of the spatial chromatin profile on gene expression is also determined in some instances. Various methods further develop research tools, perform diagnostics, and treat individuals based on sequence effects on gene expression levels.

公开(公告)号：US12131801B2

公开(公告)日：2024-10-29

申请号：US18513348

申请日：2023-11-17

Applicant: Genentech, Inc. ,  Simons Foundation ,  New York University

Inventor： Vladimir Gligorijevic ,  Richard Bonneau ,  Kyunghyun Cho

IPC: G01N33/48 ,  G16B15/00 ,  G16B30/20

CPC classification number: G16B15/00 ,  G16B30/20

Abstract: A protein design system includes one or more processors configured to modify, by a modifier, an input sequence corresponding to a protein, the input sequence comprising a data structure indicating a plurality of amino acid residues of the protein; map, by an encoder, the modified sequence to a latent space; predict, by a length predictor, a length difference between the mapped sequence and a target sequence based on at least one target function of the target sequence; identify, by a function classifier, at least one sequence function of the modified sequence; transform, by a length transformer, the modified sequence based on the length difference and the at least one sequence function; and generate, by a decoder, a candidate for the target sequence based on the transformed sequence.

公开(公告)号：US20210074378A1

公开(公告)日：2021-03-11

申请号：US16965292

申请日：2019-01-28

Applicant: The Trustees of Princeton University ,  The Simons Foundation, Inc. ,  The Rockefeller University

Inventor： Jian Zhou ,  Christopher Y. Park ,  Chandra Theesfeld ,  Robert B. Darnell ,  Olga G. Troyanskaya

IPC: G16B20/00 ,  C12Q1/6869 ,  G16B40/20

Abstract: Processes to identify variants that affect biochemical regulation are described. Generally, models are used to identify variants that affect biochemical regulation, which can be used in several downstream applications. A pathogenicity of identified variants is also determined in some instances, which can also be used in several. Various methods further develop research tools, perform diagnostics, and treat individuals based on identified variants.

公开(公告)号：US20250149109A1

公开(公告)日：2025-05-08

申请号：US18893802

申请日：2024-09-23

Applicant: Genentech, Inc. ,  Simons Foundation ,  New York University

Inventor： Vladimir Gligorijevic ,  Richard Bonneau ,  Kyunghyun Cho

IPC: G16B15/00 ,  G16B30/20

Abstract: A protein design system includes one or more processors configured to modify, by a modifier, an input sequence corresponding to a protein, the input sequence comprising a data structure indicating a plurality of amino acid residues of the protein; map, by an encoder, the modified sequence to a latent space; predict, by a length predictor, a length difference between the mapped sequence and a target sequence based on at least one target function of the target sequence; identify, by a function classifier, at least one sequence function of the modified sequence; transform, by a length transformer, the modified sequence based on the length difference and the at least one sequence function; and generate, by a decoder, a candidate for the target sequence based on the transformed sequence.