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    Low voltage differential swing (LVDS) signal driver circuit with low PVT sensitivity
    2.
    发明授权
    Low voltage differential swing (LVDS) signal driver circuit with low PVT sensitivity 有权
    具有低PVT灵敏度的低电压差动摆幅（LVDS）信号驱动电路

    公开(公告)号：US06788116B1

    公开(公告)日：2004-09-07

    申请号：US10205853

    申请日：2002-07-26

    申请人： Richard W. Cook ,  Stephen J. O'Brien ,  Roy L. Yarbrough

    发明人： Richard W. Cook ,  Stephen J. O'Brien ,  Roy L. Yarbrough

    IPC分类号： H03B100

    CPC分类号： H04L25/028 ,  H04L25/0272

    摘要： A low voltage differential swing (LVDS) signal driver having a constant output differential voltage (Vod) over variations in circuit fabrication processes, power supply voltages and operating temperatures (PVT). The minimum and maximum values of the LVDS output signal are monitored and, based upon the difference between them, a signal is provided to the circuit to control the LVDS output signal such that its peak-to-peak value is maintained at a determined value.

    摘要翻译： 低电压差动摆幅（LVDS）信号驱动器具有恒定的输出差分电压（Vod），超过电路制造过程，电源电压和工作温度（PVT）的变化。 监视LVDS输出信号的最小值和最大值，并且根据它们之间的差异，向电路提供一个信号以控制LVDS输出信号，使得它的峰 - 峰值保持在一个确定的值。

    Delayed progression to aids by a missense allele of the CCR2 gene
    5.
    发明授权
    Delayed progression to aids by a missense allele of the CCR2 gene 失效
    CCR2基因的错义等位基因延迟进展到辅助

    公开(公告)号：US06600030B2

    公开(公告)日：2003-07-29

    申请号：US09131827

    申请日：1998-08-10

    申请人： Michael Dean ,  Stephen J. O'Brien ,  Michael Smith ,  Mary Carrington

    发明人： Michael Dean ,  Stephen J. O'Brien ,  Michael Smith ,  Mary Carrington

    IPC分类号： A61K3817

    CPC分类号： C12Q1/703 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K14/7158 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： The present invention relates to a CCR2 deletion mutant, designated “CCR2-64I.” CCR2 is a C—C chemokine receptor and has been implicated as a co-receptor for HIV-1. It has been discovered that the presence of the CCR2-64I allele correlates with a postponement of AIDS outcomes, and that infected individuals who have the CCR2-64I allele are at a reduced risk for progression from HIV-1 infection to the development of clinical AIDS and death. Isolated nucleic acid molecule encoding CCR2-64I and the establishment of cell lines that express CCR2-64I provides valuable tools for continuing research on HIV infection. Diagnostic methods for analysis of the allelic frequency of CCR2 wild-type and 64I genes are provided. In addition, antibodies which bind to CCR2-64I, CCR2-64I variants, and CCR2 binding agents represent potential anti-HIV agents.

    摘要翻译： 本发明涉及CCR2缺失突变体，命名为“CCR2-64I”。 CCR2是C-C趋化因子受体，并且被认为是HIV-1的共受体。 已经发现，CCR2-64I等位基因的存在与艾滋病结局的推迟相关，并且具有CCR2-64I等位基因的感染个体具有从HIV-1感染进展到临床艾滋病发展的风险降低 和死亡。 编码CCR2-64I的分离的核酸分子和表达CCR2-64I的细胞系的建立为继续研究HIV感染提供了宝贵的工具。 提供了分析CCR2野生型和64I基因等位基因频率的诊断方法。 此外，结合CCR2-64I，CCR2-64I变体和CCR2结合剂的抗体代表潜在的抗HIV剂。