公开(公告)号：US20120028953A1

公开(公告)日：2012-02-02

申请号：US12920181

申请日：2009-02-27

申请人： Stephen Roughley ,  Steven Walls ,  Terance Hart ,  Rachel Parsons ,  Paul Brough ,  Christopher Graham ,  Alba Macias

发明人： Stephen Roughley ,  Steven Walls ,  Terance Hart ,  Rachel Parsons ,  Paul Brough ,  Christopher Graham ,  Alba Macias

IPC分类号： A61K31/397 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  A61K31/4427 ,  A61K31/506 ,  A61K31/497 ,  A61K31/501 ,  A61K31/444 ,  A61K31/4439 ,  A61P29/00 ,  A61P1/08 ,  A61P25/00 ,  A61P25/08 ,  A61P9/00 ,  A61P9/10 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  A61P33/00 ,  A61P31/12 ,  A61P31/04 ,  A61P19/10 ,  A61P1/00 ,  C07D205/04

CPC分类号： A61K31/506 ,  A61K31/397 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/495 ,  A61K31/497 ,  A61K31/501 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14

摘要： Compounds of formula (I) are inhibitors of fatty acid amide hydrolase, (FAAH), and which are useful in the treatment of diseases or medical conditions which benefit from inhibition of FAAH activity, such as anxiety, depression pain, inflammation, and eating, sleep, neurodegenerative and movement disorders: Formula (I) Wherein Ar1 is optionally substituted phenyl or optionally substituted monocyclic heteroaryl having 5 or 6 ring atoms; Ar2 is optionally substituted phenyl, optionally substituted monocyclic heteroaryl having 5 or 6 ring atoms or optionally substituted fused bicyclic heteroaryl having 5 or 6 ring atoms in each fused ring; and Ar3 is a divalent radical selected from the group consisting of optionally substituted phenylene and optionally substituted monocyclic heteroarylene radicals having 5 or 6 ring atoms.

摘要翻译： 式（I）化合物是脂肪酰胺水解酶（FAAH）的抑制剂，它们可用于治疗由于抑制FAAH活性而引起的疾病或医学病症，例如焦虑，抑郁症，炎症和饮食， 睡眠，神经变性和运动障碍：式（I）其中Ar1是任选取代的苯基或具有5或6个环原子的任选取代的单环杂芳基; Ar2是任选取代的苯基，任选取代的具有5或6个环原子的单环杂芳基或在每个稠环中具有5或6个环原子的任选取代的稠合双环杂芳基; 并且Ar 3是选自任选取代的亚苯基和具有5或6个环原子的任选取代的单环亚芳基的二价基团。

公开(公告)号：US08450346B2

公开(公告)日：2013-05-28

申请号：US12920181

申请日：2009-02-27

申请人： Stephen Roughley ,  Steven Walls ,  Terance Hart ,  Rachel Parsons ,  Paul Brough ,  Christopher Graham ,  Alba Macias

发明人： Stephen Roughley ,  Steven Walls ,  Terance Hart ,  Rachel Parsons ,  Paul Brough ,  Christopher Graham ,  Alba Macias

IPC分类号： A61K31/397 ,  A61K31/4427 ,  A61K31/495 ,  C07D205/00 ,  C07D213/24 ,  C07D237/10

CPC分类号： A61K31/506 ,  A61K31/397 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/495 ,  A61K31/497 ,  A61K31/501 ,  C07D205/04 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14

摘要： Compounds of formula (I) are inhibitors of fatty acid amide hydrolase, (FAAH), and which are useful in the treatment of diseases or medical conditions which benefit from inhibition of FAAH activity, such as anxiety, depression pain, inflammation, and eating, sleep, neurodegenerative and movement disorders: Formula (I) Wherein Ar1 is optionally substituted phenyl or optionally substituted monocyclic heteroaryl having 5 or 6 ring atoms; Ar2 is optionally substituted phenyl, optionally substituted monocyclic heteroaryl having 5 or 6 ring atoms or optionally substituted fused bicyclic heteroaryl having 5 or 6 ring atoms in each fused ring; and Ar3 is a divalent radical selected from the group consisting of optionally substituted phenylene and optionally substituted monocyclic heteroarylene radicals having 5 or 6 ring atoms.

摘要翻译： 式（I）化合物是脂肪酰胺水解酶（FAAH）的抑制剂，它们可用于治疗由于抑制FAAH活性而引起的疾病或医学病症，例如焦虑，抑郁症，炎症和饮食， 睡眠，神经变性和运动障碍：式（I）其中Ar1是任选取代的苯基或具有5或6个环原子的任选取代的单环杂芳基; Ar2是任选取代的苯基，任选取代的具有5或6个环原子的单环杂芳基或在每个稠环中具有5或6个环原子的任选取代的稠合双环杂芳基; 并且Ar 3是选自任选取代的亚苯基和具有5或6个环原子的任选取代的单环亚芳基的二价基团。