公开(公告)号：US5200415A

公开(公告)日：1993-04-06

申请号：US783869

申请日：1991-10-29

申请人： Takeo Higashino ,  Yukio Suzuki ,  Takehiko Sasahara ,  Tetsu Saito ,  Daisuke Mochizuki

发明人： Takeo Higashino ,  Yukio Suzuki ,  Takehiko Sasahara ,  Tetsu Saito ,  Daisuke Mochizuki

IPC分类号： C07D519/00

CPC分类号： C07D519/00

摘要： Described herein are pyrazolo[1,5-a]pyridine-3-carboxylic acid derivatives represented by the following formula (I): ##STR1## wherein R.sub.1 and R.sub.2 individually mean a hydrogen atom or a lower alkyl group, R.sub.3 denotes an azabicyclo group containing a tertiary nitrogen atom, and Y stands for --O-- or --NH--, or salts thereof. Their preparation process and serotonin receptor antagonists containing them as active ingredients are also described.

公开(公告)号：US4182878A

公开(公告)日：1980-01-08

申请号：US893527

申请日：1978-04-04

申请人： Eisaku Hayashi ,  Takeo Higashino ,  Shin-ichi Suzuki

发明人： Eisaku Hayashi ,  Takeo Higashino ,  Shin-ichi Suzuki

IPC分类号： A61K31/505 ,  A61P35/00 ,  C07D487/04 ,  A61K31/415

CPC分类号： C07D487/04

摘要： Novel derivatives of 1-phenyl-1H-pyrazolo[3,4-d]pyrimidine substituted at the 4-position of the pyrimidine ring are provided. A typical example is 1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4-carbonitrile. The compounds exhibit excellent anti-carcinogenic activities as evidenced by the animal test with mice.

摘要翻译： 提供了在嘧啶环的4-位取代的1-苯基-1H-吡唑并[3,4-d]嘧啶的新衍生物。 典型的实例是1-苯基-1H-吡唑并[3,4-d]嘧啶-4-甲腈。 该化合物表现出优异的抗致癌活性，如通过小鼠的动物试验证实的。