公开(公告)号：US09329176B2

公开(公告)日：2016-05-03

申请号：US12949052

申请日：2010-11-18

Applicant: Yuh-Lin Wang ,  Ting-Yu Liu ,  Huai-Hsien Wang

Inventor： Yuh-Lin Wang ,  Ting-Yu Liu ,  Huai-Hsien Wang

IPC: G01N21/65 ,  G01N33/569 ,  G01N33/58 ,  G01N33/553 ,  G01N33/543

CPC classification number: G01N33/54353 ,  C40B30/06 ,  G01N21/658 ,  G01N33/553 ,  G01N33/56911 ,  G01N33/587

Abstract: A surface-enhanced Raman spectroscopic (SERS) system for detecting a biomolecule. The system includes a substrate, an array of nanoparticles disposed on the substrate, each being partially embedded in the substrate and having a non-embedded surface, and a linking agent disposed on the non-embedded surface of each of the nanoparticles. The array of nanoparticles has a uniform interparticle gap of 1-50 nm and the linking agent is capable of binding to the biomolecule.

Abstract translation: 用于检测生物分子的表面增强拉曼光谱（SERS）系统。 该系统包括衬底，布置在衬底上的纳米颗粒阵列，每个纳米颗粒部分地嵌入衬底中并具有非嵌入表面，以及设置在每个纳米颗粒的非嵌入表面上的连接剂。 纳米颗粒阵列具有1-50nm的均匀颗粒间隙，并且连接剂能够结合生物分子。

公开(公告)号：US20120129707A1

公开(公告)日：2012-05-24

申请号：US12949052

申请日：2010-11-18

Applicant: Yuh-Lin Wang ,  Ting-Yu Liu ,  Huai-Hsien Wang

Inventor： Yuh-Lin Wang ,  Ting-Yu Liu ,  Huai-Hsien Wang

IPC: C40B30/04 ,  C40B60/12

CPC classification number: G01N33/54353 ,  C40B30/06 ,  G01N21/658 ,  G01N33/553 ,  G01N33/56911 ,  G01N33/587

Abstract: A surface-enhanced Raman spectroscopic (SERS) system for detecting a biomolecule. The system includes a substrate, an array of nanoparticles disposed on the substrate, each being partially embedded in the substrate and having a non-embedded surface, and a linking agent disposed on the non-embedded surface of each of the nanoparticles. The array of nanoparticles has a uniform interparticle gap of 1-50 nm and the linking agent is capable of binding to the biomolecule.

Abstract translation: 用于检测生物分子的表面增强拉曼光谱（SERS）系统。 该系统包括衬底，布置在衬底上的纳米颗粒阵列，每个纳米颗粒部分地嵌入衬底中并具有非嵌入表面，以及设置在每个纳米颗粒的非嵌入表面上的连接剂。 纳米颗粒阵列具有1-50nm的均匀颗粒间隙，并且连接剂能够结合生物分子。

公开(公告)号：US20080208315A1

公开(公告)日：2008-08-28

申请号：US11710999

申请日：2007-02-27

Applicant: Ming-Chien Yang ,  Juey-Jen Hwang ,  Li-Ying Huang ,  Ting-Yu Liu

Inventor： Ming-Chien Yang ,  Juey-Jen Hwang ,  Li-Ying Huang ,  Ting-Yu Liu

IPC: A61F2/06

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/42 ,  A61L2300/432 ,  A61L2300/62

Abstract: A stent for coronary vessels, having a surface of multilayer immobilized structures, includes a stent body and a number of polyelectrolyte complex (PEC) layers stacking and being immobilized on the surface of the stent body, in which the PEC layer is formed of a polymer layer and an anticoagulant layer. The coronary stent is capable of effectively improving the hemocompatibility longevity over conventional stent using surface encapsulation of an anticoagulant layer for hemocompatibility improvement. Furthermore, the coronary stent can be use as a drug-eluting coronary stent, thus allowing for the time-releasing of drugs, and further preventing the thickening of vascular smooth muscle cells for causing vascular thrombosis.