公开(公告)号：US20060019272A1

公开(公告)日：2006-01-26

申请号：US11122329

申请日：2005-05-03

申请人： Mark Geraci ,  Todd Bull ,  Norbert Voelkel ,  Christopher Coldren

发明人： Mark Geraci ,  Todd Bull ,  Norbert Voelkel ,  Christopher Coldren

IPC分类号： C12Q1/68

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2800/12 ,  G01N2800/321

摘要： Disclosed are methods to diagnose a patient that has a pulmonary disease, and particularly, pulmonary arterial hypertension, using biomarkers that are differentially regulated in the peripheral blood cells of patients with such disease as compared to individuals that do not have the disease. Also disclosed are methods to diagnose a patient that has idiopathic pulmonary arterial hypertension as compared to pulmonary arterial hypertension associated with secondary causes. Pluralities of nucleotides and antibodies useful in the invention are described. Methods of identifying compounds with the potential to treat pulmonary arterial hypertension (PAH) are also described.

摘要翻译： 公开了使用与患有该疾病的个体相比，在患有这种疾病的患者的外周血细胞中差异调节的生物标志物来诊断具有肺部疾病，特别是肺动脉高血压的患者的方法。 还公开了与与次要原因相关的肺动脉高压相比，诊断具有特发性肺动脉高压的患者的方法。 描述了可用于本发明的多种核苷酸和抗体。 还描述了鉴定具有治疗肺动脉高压（PAH）潜力的化合物的方法。