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1.发明申请Gefitinib Sensitivity-Related Gene Expression and Products and Methods Related Thereto 有权吉非替尼敏感性相关基因表达及相关产品及方法公开(公告)号：US20070270505A1
公开(公告)日：2007-11-22
申请号：US10587052
申请日：2005-01-24
申请人： Paul Bunn Jr. , Christopher Coldren , Wilbur Franklin , Mark Geraci , Barbara Helfrich , Fred Hirsch , Razvan Lapadat , Michio Sugita , Samir Witta
发明人： Paul Bunn Jr. , Christopher Coldren , Wilbur Franklin , Mark Geraci , Barbara Helfrich , Fred Hirsch , Razvan Lapadat , Michio Sugita , Samir Witta
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136
摘要： Disclosed is the identification, provision and use of a panel of biomarkers that predict sensitivity or resistance to gefitinib and other EGFR inhibitors, and products and processes related thereto. Specifically, a method is described for selecting a cancer patient who is predicted to benefit from therapeutic administration of an EGFR inhibitor, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitor. Also described is a method to identify molecules that interact with the EGFR pathway to allow or enhance responsiveness to EGFR inhibitors, as well as a plurality of polynucleotides or antibodies for the detection of the expression of genes that are indicative of sensitivity or resistance to EGFR inhibitors, an agonist thereof, or a drug having substantially similar biological activity as EGFR inhibitors. A method to identify a compound with the potential to enhance the efficacy of EGFR inhibitors is also described.
摘要翻译： 公开了鉴定，提供和使用一组生物标志物，其预测对吉非替尼和其他EGFR抑制剂的敏感性或抗性，以及与之相关的产品和过程。 具体地说，描述了一种用于选择预期从治疗性施用EGFR抑制剂，其激动剂或具有与EGFR抑制剂具有实质上相似的生物学活性的药物中受益的癌症患者的方法。 还描述了鉴定与EGFR途径相互作用以允许或增强对EGFR抑制剂的反应性的分子的方法，以及用于检测指示EGFR抑制剂的敏感性或抗性的基因表达的多种多核苷酸或抗体 ，其激动剂，或具有与EGFR抑制剂基本相似的生物学活性的药物。 还描述了鉴定具有增强EGFR抑制剂功效潜力的化合物的方法。
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公开(公告)号：US20080096276A1
公开(公告)日：2008-04-24
申请号：US11843676
申请日：2007-08-23
申请人： David Hallahan , Christopher Coldren , Dennis Flint , Hong Wang
发明人： David Hallahan , Christopher Coldren , Dennis Flint , Hong Wang
CPC分类号： C12N9/1085 , C12N15/8243 , C12N15/8279
摘要： This invention pertains to nucleic acid fragments encoding plant proteins that are homologs to the cis-prenyltransferases UPP synthase from the bacterium Micrococcus luteus or Dedol-PP synthase from yeast Saccharomyces cerevisiae. More specifically, this invention pertains to cis-prenyltransferase homologs from wheat, grape, soybean, rice, African daisy, rubber tree latex and pot marigold.
摘要翻译： 本发明涉及编码植物蛋白质的核酸片段，其与来自酵母酿酒酵母的细菌微球菌或Dedol-PP合酶的顺式 - 异戊烯基转移酶UPP合酶的同系物。 更具体地说，本发明涉及来自小麦，葡萄，大豆，大米，非洲雏菊，橡胶树乳胶和万寿菊的顺式 - 异戊烯基转移酶同源物。
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公开(公告)号：US07880058B2
公开(公告)日：2011-02-01
申请号：US11843676
申请日：2007-08-23
申请人： David L Hallahan , Christopher Coldren , Dennis Flint , Hong Wang
发明人： David L Hallahan , Christopher Coldren , Dennis Flint , Hong Wang
CPC分类号： C12N9/1085 , C12N15/8243 , C12N15/8279
摘要： This invention pertains to nucleic acid fragments encoding plant proteins that are homologs to the cis-prenyltransferases UPP synthase from the bacterium Micrococcus luteus or Dedol-PP synthase from yeast Saccharomyces cerevisiae. More specifically, this invention pertains to cis-prenyltransferase homologs from wheat, grape, soybean, rice, African daisy, rubber tree latex and pot marigold.
摘要翻译： 本发明涉及编码植物蛋白质的核酸片段，其与来自酵母酿酒酵母的细菌微球菌或Dedol-PP合酶的顺式 - 异戊烯基转移酶UPP合酶的同系物。 更具体地说，本发明涉及来自小麦，葡萄，大豆，大米，非洲雏菊，橡胶树乳胶和万寿菊的顺式 - 异戊烯基转移酶同源物。
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公开(公告)号：US20060257065A1
公开(公告)日：2006-11-16
申请号：US11489067
申请日：2006-07-19
申请人： Christopher Coldren , Larry Coldren
发明人： Christopher Coldren , Larry Coldren
CPC分类号： H01L31/035236 , B82Y20/00 , G02F1/025 , G02F1/0356 , G02F1/2255 , G02F1/2257 , G02F2/004 , G02F2001/212 , G02F2002/008 , G02F2201/127 , H01L31/105 , H01S5/026 , H01S5/0262 , H01S5/0265 , H01S5/0427 , H01S5/06256 , H01S5/1209
摘要： Traveling-wave optoelectronic wavelength conversion is provided by a monolithic optoelectronic integrated circuit that includes an interconnected traveling-wave photodetector and traveling-wave optical modulator with a widely tunable laser source. Either parallel and series connections between the photodetector and modulator may be used. An input signal modulated onto a first optical wavelength develops a traveling wave voltage on transmission line electrodes of the traveling-wave photodetector, and this voltage is coupled via an interconnecting transmission line of the same characteristic impedance to transmission line electrodes of the traveling-wave optical modulator to modulate the signal onto a second optical wavelength derived from the tunable laser. The traveling wave voltage is terminated in a load resistor having the same characteristic impedance as the photodetector and modulator transmission lines. However, the interconnecting transmission lines and the load resistor may have different impedances than the photodetector and modulator.
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公开(公告)号：US20050018941A1
公开(公告)日：2005-01-27
申请号：US10724942
申请日：2003-12-01
申请人： Christopher Coldren , Larry Coldren
发明人： Christopher Coldren , Larry Coldren
CPC分类号： H01L31/035236 , B82Y20/00 , G02F1/025 , G02F1/0356 , G02F1/2255 , G02F1/2257 , G02F2/004 , G02F2001/212 , G02F2002/008 , G02F2201/127 , H01L31/105 , H01S5/026 , H01S5/0262 , H01S5/0265 , H01S5/0427 , H01S5/06256 , H01S5/1209
摘要： Traveling-wave optoelectronic wavelength conversion is provided by a monolithic optoelectronic integrated circuit that includes an interconnected traveling-wave photodetector and traveling-wave optical modulator with a widely tunable laser source. Either parallel and series connections between the photodetector and modulator may be used. An input signal modulated onto a first optical wavelength develops a traveling wave voltage on transmission line electrodes of the traveling-wave photodetector, and this voltage is coupled via an interconnecting transmission line of the same characteristic impedance to transmission line electrodes of the traveling-wave optical modulator to modulate the signal onto a second optical wavelength derived from the tunable laser. The traveling wave voltage is terminated in a load resistor having the same characteristic impedance as the photodetector and modulator transmission lines. However, the interconnecting transmission lines and the load resistor may have different impedances than the photodetector and modulator.
摘要翻译： 行波光电波长转换由单片光电集成电路提供，该集成电路包括具有广泛可调激光源的互连行波光电探测器和行波光调制器。 可以使用光电检测器和调制器之间的并联和串联连接。 调制到第一光波长的输入信号在行波光电检测器的传输线电极上产生行波电压，并且该电压通过相同特性阻抗的互连传输线耦合到行波光学器件的传输线电极 调制器将信号调制到从可调激光器得到的第二光波长上。 行波电压终止于具有与光电检测器和调制器传输线相同的特性阻抗的负载电阻器中。 然而，互连传输线路和负载电阻器可以具有与光电检测器和调制器不同的阻抗。
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公开(公告)号：US20060140528A1
公开(公告)日：2006-06-29
申请号：US11359824
申请日：2006-02-22
申请人： Christopher Coldren , Larry Coldren
发明人： Christopher Coldren , Larry Coldren
CPC分类号： H01L31/035236 , B82Y20/00 , G02F1/025 , G02F1/0356 , G02F1/2255 , G02F1/2257 , G02F2/004 , G02F2001/212 , G02F2002/008 , G02F2201/127 , H01L31/105 , H01S5/026 , H01S5/0262 , H01S5/0265 , H01S5/0427 , H01S5/06256 , H01S5/1209
摘要： Traveling-wave optoelectronic wavelength conversion is provided by a monolithic optoelectronic integrated circuit that includes an interconnected traveling-wave photodetector and traveling-wave optical modulator with a widely tunable laser source. Either parallel and series connections between the photodetector and modulator may be used. An input signal modulated onto a first optical wavelength develops a traveling wave voltage on transmission line electrodes of the traveling-wave photodetector, and this voltage is coupled via an interconnecting transmission line of the same characteristic impedance to transmission line electrodes of the traveling-wave optical modulator to modulate the signal onto a second optical wavelength derived from the tunable laser. The traveling wave voltage is terminated in a load resistor having the same characteristic impedance as the photodetector and modulator transmission lines. However, the interconnecting transmission lines and the load resistor may have different impedances than the photodetector and modulator.
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7.发明申请Diagnosis of disease and monitoring of therapy using gene expression analysis of peripheral blood cells 审中-公开使用外周血细胞的基因表达分析诊断疾病和治疗监测公开(公告)号：US20060019272A1
公开(公告)日：2006-01-26
申请号：US11122329
申请日：2005-05-03
申请人： Mark Geraci , Todd Bull , Norbert Voelkel , Christopher Coldren
发明人： Mark Geraci , Todd Bull , Norbert Voelkel , Christopher Coldren
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N2800/12 , G01N2800/321
摘要： Disclosed are methods to diagnose a patient that has a pulmonary disease, and particularly, pulmonary arterial hypertension, using biomarkers that are differentially regulated in the peripheral blood cells of patients with such disease as compared to individuals that do not have the disease. Also disclosed are methods to diagnose a patient that has idiopathic pulmonary arterial hypertension as compared to pulmonary arterial hypertension associated with secondary causes. Pluralities of nucleotides and antibodies useful in the invention are described. Methods of identifying compounds with the potential to treat pulmonary arterial hypertension (PAH) are also described.
摘要翻译： 公开了使用与患有该疾病的个体相比，在患有这种疾病的患者的外周血细胞中差异调节的生物标志物来诊断具有肺部疾病，特别是肺动脉高血压的患者的方法。 还公开了与与次要原因相关的肺动脉高压相比，诊断具有特发性肺动脉高压的患者的方法。 描述了可用于本发明的多种核苷酸和抗体。 还描述了鉴定具有治疗肺动脉高压（PAH）潜力的化合物的方法。
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公开(公告)号：US07273737B2
公开(公告)日：2007-09-25
申请号：US10700171
申请日：2003-11-03
CPC分类号： C12N9/1085 , C12N15/8243 , C12N15/8279
摘要： This invention pertains to nucleic acid fragments encoding plant proteins that are homologs to the cis-prenyltransferases UPP synthase from the bacterium Micrococcus luteus or Dedol-PP synthase from yeast Saccharomyces cerevisiae. More specifically, this invention pertains to cis-prenyltransferase homologs from wheat, grape, soybean, rice, African daisy, rubber tree latex and pot marigold.
摘要翻译： 本发明涉及编码植物蛋白质的核酸片段，其与来自酵母酿酒酵母的细菌微球菌或Dedol-PP合酶的顺式 - 异戊烯基转移酶UPP合酶的同系物。 更具体地说，本发明涉及来自小麦，葡萄，大豆，大米，非洲雏菊，橡胶树乳胶和万寿菊的顺式 - 异戊烯基转移酶同源物。
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公开(公告)号：US20050202614A1
公开(公告)日：2005-09-15
申请号：US11075951
申请日：2005-03-09
IPC分类号： H01S5/183 , H01S5/32 , H01S5/323 , H01L21/338 , H01S5/00
CPC分类号： H01S5/18305 , B82Y20/00 , H01S5/18352 , H01S5/3201 , H01S5/32366 , H01S5/34306 , H01S2302/00
摘要： In an active region of an optical-electronic semiconductor device, nitrogen is incorporated in a barrier adjacent a GaNAs-based (e.g., GaInNAs) quantum well to improve device performance at wavelength bands above 1.2 microns. In a specific example embodiment, a mirror or cladding layer is grown over the active region in a manner that removes nitrogen complex otherwise present with Ga—N bonds in the active region. The embodiment can be implemented as one of a number of configurations including vertical cavity surface emitting lasers (VCSEL) and edge emitting lasers.
摘要翻译： 在光电子半导体器件的有源区中，氮邻近基于GaNA的（例如GaInNA）量子阱的势垒中并入，以提高在1.2微米以上的波段的器件性能。 在具体的示例性实施例中，以活性区域中以Ga-N键除去另外存在的氮复合物的方式在有源区上生长反射镜或包覆层。 该实施例可以实现为包括垂直腔表面发射激光器（VCSEL）和边缘发射激光器的多种配置之一。
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公开(公告)号：US06645747B1
公开(公告)日：2003-11-11
申请号：US09655908
申请日：2000-09-06
IPC分类号： C12N912
CPC分类号： C12N9/1085 , C12N15/8243 , C12N15/8279
摘要： This invention pertains to nucleic acid fragments encoding plant proteins that are homologs to the cis-prenyltransferases UPP synthase from the bacterium Micrococcus luteus or Dedol-PP synthase from yeast Saccharomyces cerevisiae. More specifically, this invention pertains to cis-prenyltransferase homologs from wheat, grape, soybean, rice, African daisy, rubber tree latex and pot marigold.
摘要翻译： 本发明涉及编码植物蛋白质的核酸片段，其与来自酵母酿酒酵母的细菌微球菌或Dedol-PP合酶的顺式 - 异戊烯基转移酶UPP合酶的同系物。 更具体地说，本发明涉及来自小麦，葡萄，大豆，大米，非洲雏菊，橡胶树乳胶和万寿菊的顺式 - 异戊烯基转移酶同源物。
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