专利检索 ap:"VALENTINA ALEXANDROVNA AVERIAN" 第 1 页

1.

发明授权
Method of preparing the sodium salt of 6 - (5 - methyl - 3 - phenyl - 4 - isoxazolecarboxamido)-penicillanic acid monohydrate 失效
标题翻译：制备6 - （5-甲基-3-苯基-4-异恶唑烷酰胺） - 壬二酸单一盐酸盐的方法

公开(公告)号：US3567709A

公开(公告)日：1971-03-02

申请号：US3567709D

申请日：1967-12-21

申请人： MARINA ALEXEEVNA PANINA , VALENTINA ALEXANDROVNA AVERIAN , IVAN TIMOFEEBICH STRUKOV

发明人： PANINA MARINA ALEXEEVNA , AVERIANOVA VALENTINA ALEXANDRO , STRUKOV IVAN TIMOFEEBICH

IPC分类号： C07D499/00 , C07D499/76 , C07D99/16

CPC分类号： C07D499/00

摘要： A METHOD OF PRODUCING THE SODIUM SALT OF 6-(5-METHYL3-PHENYL - 4 - ISOXAZOLECARBOXAMIDO)-PENICILLANIC ACID MONOHYDRATE BY THE ACYLATION OF 6-AMINOPENICILLANIC ACID WITH 5 - METHYL - 3 - PHENYLISOXAZOLE - 4 CARBONYL CHLORIDE IN AQUEOUS ACETONE SOLUTION AND IN THE PRESENCE OF SODIUM BICARBONATE. THE RESULTANT SODIUM SALT OF 6-(5METHYL - 3 - PHENYL - 4 - ISOXAZOLECARBOXAMIDO)-PENICILLANIC ACID IS CONVERTED INTO THE FREE ACID BY ACIDIFYING THE REACTION MIXTURE TO A PH OF 2.5-3, THE ACID THUS OBTAINED IS EXTRACTED WITH BUTYL ACETATE, AND THE SOLUTION OF 6-(5-METHYL - 3 - PHENYL - 4 - ISOXAZOLECARBOXAMIDO)-PENICILLANIC ACID IS TREATED WITH AN EQUIMOLECULAR AMOUNT OF SODIUM HYDROXIDE IN ALCOHOLIC SOLUTION.