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    MALTOL ETHER PROCESSES AND INTERMEDIATES
    2.
    发明申请
    MALTOL ETHER PROCESSES AND INTERMEDIATES 有权
    MALTOL过程和中间件

    公开(公告)号：US20110245516A1

    公开(公告)日：2011-10-06

    申请号：US13133481

    申请日：2009-12-08

    申请人： Yasunori Aoyama

    发明人： Yasunori Aoyama

    IPC分类号： C07D309/40

    CPC分类号： C07D309/38

    摘要： Novel processes and intermediates are provided according to the general reaction scheme: Formula I, II, III, IV (I), (II), (III), (IV) utilizing a ruthenium catalyst in an oxidative cleavage of the triene 4 whereby an aldehyde may be produced and optionally taken on to a carboxylic acid 5: Formula V (V)

    摘要翻译： 根据通用反应方案提供新的方法和中间体：在三烯4的氧化裂解中使用钌催化剂的式I，II，III，IV（I），（II），（III），（IV） 可以制备醛，并任选地加入到羧酸5中：式V（V）

    Ultrasonic transducer
    3.
    发明授权
    Ultrasonic transducer 有权
    超声波换能器

    公开(公告)号：US07930940B2

    公开(公告)日：2011-04-26

    申请号：US12007767

    申请日：2008-01-15

    申请人： Akira Onodera ,  Yasunori Aoyama

    发明人： Akira Onodera ,  Yasunori Aoyama

    IPC分类号： G01N29/00

    CPC分类号： G01N29/28 ,  G01N29/043 ,  G01N29/223 ,  G01N29/34 ,  G01N2291/044 ,  G01N2291/101

    摘要： An ultrasonic transducer incorporated into an ultrasonic inspection apparatus for examining existence of defect in a sample dipped in water comprises a transducer main part having an oscillator which projects an ultrasonic wave to the sample, receives the reflected wave from the sample and outputs the received reflected wave as an echo signal, a transmitter substrate producing a drive pulse for emitting the ultrasonic wave to the oscillator, a receiver substrate for amplifying the echo signal, a housing for containing therein both substrates electrically connected, and connecting member for electrically connecting between a signal input/output terminal and the side of the oscillator in the transducer main part, wherein, when a maximum operational frequency of the ultrasonic wave emitted from the oscillator is referred to as fmax [MHz], the connecting member is set at a length of 100/fmax [cm] or less. Even if the sample to be examined is small, a desirable defect inspection can be achieved at an excellent examination accuracy.

    摘要翻译： 包含在超声波检查装置中的用于检查浸入水中的样品中存在缺陷的超声波换能器包括具有将超声波投射到样品的振荡器的换能器主体，从样品接收反射波并输出接收到的反射波 作为回波信号，产生用于向振荡器发射超声波的驱动脉冲的发射器基板，用于放大回波信号的接收器基板，用于容纳其中两个基板电连接的壳体和用于电连接信号输入 /输出端子和振荡器主体中的振荡器侧，其中当从振荡器发射的超声波的最大工作频率被称为fmax [MHz]时，连接构件被设置为100 / fmax [cm]以下。 即使被检查样本小，也可以以良好的检查精度实现期望的缺陷检查。

    Ultrasonic transducer
    4.
    发明申请
    Ultrasonic transducer 有权
    超声波换能器

    公开(公告)号：US20080282805A1

    公开(公告)日：2008-11-20

    申请号：US12007767

    申请日：2008-01-15

    申请人： Akira Onodera ,  Yasunori Aoyama

    发明人： Akira Onodera ,  Yasunori Aoyama

    IPC分类号： G01N29/00

    CPC分类号： G01N29/28 ,  G01N29/043 ,  G01N29/223 ,  G01N29/34 ,  G01N2291/044 ,  G01N2291/101

    摘要： An ultrasonic transducer incorporated into an ultrasonic inspection apparatus for examining existence of defect in a sample dipped in water comprises a transducer main part having an oscillator which projects an ultrasonic wave to the sample, receives the reflected wave from the sample and outputs the received reflected wave as an echo signal, a transmitter substrate producing a drive pulse for emitting the ultrasonic wave to the oscillator, a receiver substrate for amplifying the echo signal, a housing for containing therein both substrates electrically connected, and connecting member for electrically connecting between a signal input/output terminal and the side of the oscillator in the transducer main part, wherein, when a maximum operational frequency of the ultrasonic wave emitted from the oscillator is referred to as fmax [MHz], the connecting member is set at a length of 100/fmax [cm] or less. Even if the sample to be examined is small, a desirable defect inspection can be achieved at an excellent examination accuracy.

    摘要翻译： 包含在超声波检查装置中的用于检查浸入水中的样品中存在缺陷的超声波换能器包括具有将超声波投射到样品的振荡器的换能器主体，从样品接收反射波并输出接收到的反射波 作为回波信号，产生用于向振荡器发射超声波的驱动脉冲的发射器基板，用于放大回波信号的接收器基板，用于容纳其中两个基板电连接的壳体和用于电连接信号输入 /输出端子和振荡器主体中的振荡器侧，其中当从振荡器发射的超声波的最大工作频率被称为fmax [MHz]时，连接构件被设置为100 / fmax [cm]以下。 即使被检查样本小，也可以以良好的检查精度实现期望的缺陷检查。

    Maltol ether processes and intermediates
    5.
    发明授权
    Maltol ether processes and intermediates 有权
    麦芽酚醚工艺和中间体

    公开(公告)号：US08710249B2

    公开(公告)日：2014-04-29

    申请号：US13133481

    申请日：2009-12-08

    申请人： Yasunori Aoyama

    发明人： Yasunori Aoyama

    IPC分类号： C07D309/40

    CPC分类号： C07D309/38

    摘要： Novel processes and intermediates are provided according to the general reaction scheme: Formula I, II, III, IV (I), (II), (III), (IV) utilizing a ruthenium catalyst in an oxidative cleavage of the triene 4 whereby an aldehyde may be produced and optionally taken on to a carboxylic acid 5: Formula V (V)

    摘要翻译： 根据通用反应方案提供新的方法和中间体：在三烯4的氧化裂解中使用钌催化剂的式I，II，III，IV（I），（II），（III），（IV） 可以制备醛，并任选地加入到羧酸5中：式V（V）

    Substituted 9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydor-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazines
    8.
    发明授权
    Substituted 9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydor-1H-pyrido[1,2-a]pyrrolo[1′,2′:3,4]imidazo[1,2-d]pyrazines 有权
    取代的9,11-二氧代-2,3,4a，5,9,11,13,13a-八氢-1H-吡啶并[1,2-a]吡咯并[1'，2'：3,4]咪唑并[1 ，2-d]吡嗪

    公开(公告)号：US08183372B2

    公开(公告)日：2012-05-22

    申请号：US13055046

    申请日：2009-07-23

    申请人： Brian Alvin Johns ,  Yasunori Aoyama ,  Hiroshi Yoshida ,  Yoshiyuki Taoda

    发明人： Brian Alvin Johns ,  Yasunori Aoyama ,  Hiroshi Yoshida ,  Yoshiyuki Taoda

    IPC分类号： C07D241/36

    CPC分类号： C07D471/14

    摘要： The present invention is directed to a process for the preparation of a compound of formula 1b which compound is useful as a prodrug of HIV integrase inhibitors and therefore is useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC. The process includes the steps of a) brominating a compound of formula P-7 to form a compound of formula P-8, b) treating a compound of formula P-8 with NaIO4 to form a compound of formula P-9, c) reacting a compound of formula P-9 with [(2R)-pyrrolidinylmethyl]amine of formula to form a compound of formula P-10, d) reacting a compound of formula P-10 with 2, 4-difluorobenzylamine to form a compound of formula P-11, e) treating a compound of P-11 with palladium on carbon and ammonium hydroxide to form a compound of formula 1a, and f) treating a compound of formula 1a with NaOH and ethanol to form a compound of formula 1b. The structures of the above mentioned compounds are disclosed in the specification.

    摘要翻译： 本发明涉及一种制备式1b化合物的方法，该化合物可用作HIV整合酶抑制剂的前药，因此可用于抑制HIV复制，预防和/或治疗HIV感染， 和治疗艾滋病和/或ARC。 该方法包括以下步骤：a）将式P-7化合物溴化以形成式P-8的化合物，b）用NaIO 4处理式P-8的化合物以形成式P-9的化合物，c） 使式P-9的化合物与式的[（2R） - 吡咯烷基甲基]胺反应形成式P-10的化合物，d）使式P-10的化合物与2,4-二氟苄胺反应，形成化合物 式P-11，e）用钯碳和氢氧化铵处理P-11化合物以形成式1a化合物，和f）用NaOH和乙醇处理式1a化合物以形成式1b化合物。 上述化合物的结构在说明书中公开。