公开(公告)号：US10172919B2

公开(公告)日：2019-01-08

申请号：US15537051

申请日：2015-12-29

Applicant: ACADEMIA SINICA

Inventor： Shie-Liang Hsieh ,  Yung-Chi Chang ,  Ming-Ting Huang

IPC: A61K39/00 ,  A61K38/17 ,  C07K14/705

Abstract: Disclosed herein is a method of treating influenza A virus (IAV) infection by a fusion protein. According to some embodiments of the present disclosure, the fusion protein comprises a HBD peptide and a IgG1 Fc region. According to other embodiments of the present disclosure, the fusion protein comprises a DcR3 protein and a IgG1 Fc region. The present fusion protein is found to possess inhibitory effects on IAV-induced secretion of the inflammatory cytokine, and IAV-induced infiltration of inflammatory cell into the lung tissue. Accordingly, the fusion protein is useful for developing a medicament for the treatment or prophylaxis of IAV infection and/or ameliorating pulmonary injury caused by excessive inflammation associated with IAV infection in a subject.

公开(公告)号：US12116407B2

公开(公告)日：2024-10-15

申请号：US17269991

申请日：2019-09-25

Applicant: Academia Sinica

Inventor： Shie-Liang Hsieh ,  Pei-Shan Sung ,  Ming-Ting Huang ,  An-Suei Yang ,  Chung-Ming Yu

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28 ,  A61P31/20

CPC classification number: C07K16/2803 ,  A61P25/28 ,  A61P31/20 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/77

Abstract: Provided herein is a method for treating neurodegenerative diseases, such as Alzheimer's disease (AD), by use of monoclonal antibody, which exhibits a binding affinity to Siglec-3 receptor. According to some embodiments of the present disclosure, the monoclonal antibody is capable of enhancing phagocytosis of neurotoxic peptides by immune cells thereby providing a neuroprotective effect to a subject in need thereof.