公开(公告)号：US20160033502A1

公开(公告)日：2016-02-04

申请号：US14812621

申请日：2015-07-29

Applicant: ACADEMIA SINICA

Inventor： Tzu-Ching Meng ,  Geen-Dong Chang ,  Ming-Fo Hsu

IPC: G01N33/566 ,  C07K16/44

CPC classification number: C07K16/44 ,  G01N33/6815 ,  G01N33/6842 ,  G01N2440/26

Abstract: The present invention discloses a novel isolated antibody that specifically binds to an N-phenyl-acetamide group. Also disclosed are related compositions, kits, methods for detecting protein S-nitrosylation or oxidation vivo or in vitro, and drug screening methods.

Abstract translation: 本发明公开了一种特异性结合N-苯基 - 乙酰胺基团的新型分离抗体。 还公开了相关组合物，试剂盒，用于检测蛋白质S-亚硝基化或氧化体内或体外的方法和药物筛选方法。

公开(公告)号：US10072097B2

公开(公告)日：2018-09-11

申请号：US14812621

申请日：2015-07-29

Applicant: ACADEMIA SINICA

Inventor： Tzu-Ching Meng ,  Geen-Dong Chang ,  Ming-Fo Hsu

IPC: G01N33/68 ,  C07K16/44

CPC classification number: C07K16/44 ,  G01N33/6815 ,  G01N33/6842 ,  G01N2440/26

Abstract: The present invention discloses a novel isolated antibody that specifically binds to an N-phenyl-acetamide group. Also disclosed are related compositions, kits, methods for detecting protein S-nitrosylation or oxidation vivo or in vitro, and drug screening methods.

公开(公告)号：US20190298664A1

公开(公告)日：2019-10-03

申请号：US16368654

申请日：2019-03-28

Applicant: Academia Sinica ,  Buddhist Tzu Chi Medical Foundation

Inventor： Tzu-Ching Meng ,  Chiu-Fen Yang ,  Michael Yu-Chih Chen

IPC: A61K31/10 ,  A61K33/242 ,  A61K31/727 ,  A61K45/06 ,  A61K9/00 ,  A61P9/10

Abstract: This disclosure provides method and kit for myocardial reperfusion and method for attenuating or reducing myocardial reperfusion injury. By administering protein tyrosine phosphatases inhibitor or a protein tyrosine kinases activator, cardiac injury caused by ischemia/reperfusion will be attenuated or reduced.