公开(公告)号：US20220135651A1

公开(公告)日：2022-05-05

申请号：US17430037

申请日：2020-02-17

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yiqi SEOW ,  Ming Li Lalita LAU

IPC: C07K14/71 ,  C12N15/113

Abstract: We describe a Flt-1 decoy comprising a VEGF binding domain of Flt-1 and a membrane anchoring domain, in which the Flt-1 decoy does not substantially comprise an intracellular domain.

公开(公告)号：US20190264229A1

公开(公告)日：2019-08-29

申请号：US16343503

申请日：2017-10-20

Applicant: Agency for Science, Technology and Research

Inventor： Yiqi SEOW ,  Weijie Cyrus BEH

IPC: C12N15/87

Abstract: There is provided an attachment configured to detachably couple to a fluid extruding device, the attachment comprising: a membrane having a plurality of pores configured to allow a cell to pass through while inducing a mechanical stress to the cell such that the introduction of one or more substances into the cell is facilitated; and an engaging member for coupling to the outlet of the fluid extruding device such that the membrane is in fluid communication with the outlet of the fluid extruding device, wherein the fluid extruding device is configured to extrude fluid via mechanical actuation.

公开(公告)号：US20160297820A1

公开(公告)日：2016-10-13

申请号：US14917935

申请日：2014-09-09

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yiqi SEOW ,  Fong Tian WONG ,  Yin Nah TEO

IPC: C07D473/18

CPC classification number: C07D473/18 ,  A61K38/00 ,  A61K47/55 ,  A61K47/60

Abstract: There is provided a compound comprising at least two ligands that are individually coupled to a linker, wherein each ligand is independently selected from the group consisting of a substituted benzylguanine derivative, a substituted benzylcytosine derivative, a haloalkyl moiety, a drug, a peptide, a hormone, an inorganic compound and a protein. The compound may be part of an oligomer. The compound may be employed in a method of dimerizing a pair of proteins, which may alter a biological function in a cell. There is also provided a method of forming the compound.

Abstract translation: 提供了包含至少两个分别与接头偶联的配体的化合物，其中每个配体独立地选自取代的苄基鸟嘌呤衍生物，取代的苄基胞嘧啶衍生物，卤代烷基部分，药物，肽， 激素，无机化合物和蛋白质。 该化合物可以是低聚物的一部分。 该化合物可以用于二聚化一对蛋白质的方法，这可能改变细胞中的生物学功能。 还提供了形成化合物的方法。

公开(公告)号：US20170002350A1

公开(公告)日：2017-01-05

申请号：US15100630

申请日：2014-10-17

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Yiqi SEOW

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2310/3519 ,  C12N2310/52 ,  C12N2310/531 ,  C12N2320/30

Abstract: The present invention relates to an isolated mirtron capable of binding a target nucleic acid, wherein the isolated mirtron comprises: a) a stem loop structure comprising a 5′ splice site, b) a tail sequence comprising a 3′ splice site and a polypyrimidine-comprising sequence, and c) a branch point sequence. Further, the present invention relates to vectors and pharmaceutical compositions comprising such mirtrons as well as methods of treating a disease comprising administering such pharmaceutical compositions.

Abstract translation: 本发明涉及能够结合目标核酸的分离的丝氨酸蛋白酶，其中所述分离的胞质包含：a）包含5'剪接位点的茎环结构，b）包含3'剪接位点和聚嘧啶 - 包括序列，以及c）分支点序列。 此外，本发明涉及包含这种心肌的载体和药物组合物以及治疗疾病的方法，包括施用该药物组合物。