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公开(公告)号：US20160263243A1
公开(公告)日：2016-09-15
申请号：US15069853
申请日：2016-03-14
发明人： Daulet SATPAYEV , Robert Kendall MORRISON , Karen Jane Meyrick MORRISON , Jean GUDAS , Aya JAKOBOVITS , Michael TORGOV , Zili AN
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US20180296693A1
公开(公告)日：2018-10-18
申请号：US15943527
申请日：2018-04-02
发明人： Daulet SATPAYEV , Robert Kendall MORRISON , Karen Jane Meyrick MORRISON , Jean GUDAS , Aya JAKOBOVITS , Michael TORGOV , Zili AN
IPC分类号： A61K47/68
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US20180251566A1
公开(公告)日：2018-09-06
申请号：US15895996
申请日：2018-02-13
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US20150238633A1
公开(公告)日：2015-08-27
申请号：US14634606
申请日：2015-02-27
IPC分类号： A61K47/48
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6865 , A61K2039/505 , A61P35/00 , C07K16/18 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合158P1D7蛋白的抗体药物偶联物（ADC）及其变体。 158P1D7在正常成人组织中表现出组织特异性表达，并且在胶质母细胞瘤，肺癌，膀胱癌和乳腺癌中异常表达。 因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US20140072586A1
公开(公告)日：2014-03-13
申请号：US13975214
申请日：2013-08-23
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6865 , A61K2039/505 , C07K16/18 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合158P1D7蛋白的抗体药物偶联物（ADC）及其变体。 158P1D7在正常成人组织中表现出组织特异性表达，并且在胶质母细胞瘤，肺癌，膀胱癌和乳腺癌中异常表达。 因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US20160369003A1
公开(公告)日：2016-12-22
申请号：US15085877
申请日：2016-03-30
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6865 , A61K2039/505 , C07K16/18 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3053 , C07K2317/21 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
摘要： Antibody drug conjugates (ADC's) that bind to 158P1D7 protein and variants thereof are described herein. 158P1D7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in glioblastoma, lung cancer, bladder cancer, and breast cancer. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US20150306245A1
公开(公告)日：2015-10-29
申请号：US14798302
申请日：2015-07-13
发明人： Daulet SATPAYEV , Robert Kendall MORRISON , Karen Jane Meyrick MORRISON , Jean GUDAS , Aya JAKOBOVITS , Michael TORGOV , Zili AN
IPC分类号： A61K47/48
CPC分类号： A61K47/6851 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/1001 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合191P4D12蛋白及其变体的抗体药物偶联物（ADC）。 191P4D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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8.发明申请公开(公告)号：US20130136756A1
公开(公告)日：2013-05-30
申请号：US13672419
申请日：2012-11-08
发明人： Jean GUDAS , Aya JAKOBOVITS , Zili AN , Robert Kendall MORRISON , Karen Jane Meyrick MORRISON , Xiao-chi JIA , Dennis BENJAMIN , Ruth MOSER , Peter SENTER
CPC分类号： C07K16/30 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6863 , A61K2039/505 , C07K16/3046
摘要： Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
摘要翻译： 本文描述了结合24P4C12蛋白及其变体的抗体药物偶联物（ADC）。 24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，本发明的ADC提供了用于治疗癌症的治疗组合物。
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公开(公告)号：US20210283268A1
公开(公告)日：2021-09-16
申请号：US17122786
申请日：2020-12-15
申请人： AGENSYS, INC. , SEAGEN INC.
发明人： Daulet SATPAYEV , Robert Kendall MORRISON , Karen Jane Meyrick MORRISON , Jean GUDAS , Aya JAKOBOVITS , Michael TORGOV , Zili AN
摘要： Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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公开(公告)号：US20190328898A1
公开(公告)日：2019-10-31
申请号：US16216841
申请日：2018-12-11
申请人： AGENSYS, INC.
发明人： Michael TORGOV , Robert Kendall MORRISON , Aya JAKOBOVITS , Jean GUDAS , Zili AN
摘要： Antibody drug conjugates (ADC's) that bind to 161P2F10B protein are described herein. 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
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