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1.发明授权公开(公告)号：US09643961B2
公开(公告)日：2017-05-09
申请号：US15068926
申请日：2016-03-14
Applicant: Almirall, S.A.
Inventor： Maria Prat Quinones , Silvia Fonquerna Pou , Carlos Puig Duran , Wenceslao Lumeras Amador , Jose Aiguade Bosch , Juan Francisco Caturla Javaloyes
IPC: C07D215/26 , C07D409/14 , A61K31/4709 , C07D405/12 , C07D409/12 , C07D413/14
CPC classification number: C07D409/14 , A61K31/4709 , C07D215/26 , C07D405/12 , C07D409/12 , C07D413/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
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2.发明授权公开(公告)号：US08802699B2
公开(公告)日：2014-08-12
申请号：US13939742
申请日：2013-07-11
Applicant: Almirall, S.A.
IPC: A61K31/439 , A61K31/56 , A61K45/06 , A61K31/4745 , C07D453/02
CPC classification number: A61K31/439 , A61K9/0073 , A61K9/0075 , A61K31/4745 , A61K31/56 , A61K45/06 , A61K47/26 , C07D453/02 , Y10S514/826 , A61K2300/00
Abstract: Provided is a pharmaceutical composition comprising: (i) 3-(2-hydroxy-2,2-dithien-2- ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo-[2.2.2]octane or an enantiomer, mixture of enantiomers, or a racemate thereof, wherein an anion X−with a single negative charge is associated with the positive charge of the nitrogen atom; and (ii) a phosphodiesterase IV inhibitor and methods of using the same.
Abstract translation: 本发明提供的药物组合物包含：（i）3-（2-羟基-2,2-二噻吩-2-基乙酰氧基）-1-（3-苯氧基丙基）-1-氮鎓二环[2.2.2]辛烷或对映异构体， 对映异构体或其外消旋体的混合物，其中具有单个负电荷的阴离子X与氮原子的正电荷相关联; 和（ii）磷酸二酯酶IV抑制剂及其使用方法。
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3.发明申请公开(公告)号：US20180015097A1
公开(公告)日：2018-01-18
申请号：US15668817
申请日：2017-08-04
Applicant: ALMIRALL,S.A
Inventor： Jose AIGUADE BOSCH , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: A61K31/538 , A61K31/4178 , C07D413/14 , C07D413/12 , C07D409/14 , C07D409/12 , C07D403/12 , C07D401/12 , C07D263/58 , A61K45/06 , A61K31/4709 , A61K31/428 , A61K31/423 , A61K31/4184 , C07D417/12 , C07D417/14
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
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4.发明授权公开(公告)号：US09056100B2
公开(公告)日：2015-06-16
申请号：US14311102
申请日：2014-06-20
Applicant: Almirall, S.A.
IPC: A61K31/439 , A61K31/56 , A61K31/4745 , A61K45/06 , C07D453/02
CPC classification number: A61K31/439 , A61K9/0073 , A61K9/0075 , A61K31/4745 , A61K31/56 , A61K45/06 , A61K47/26 , C07D453/02 , Y10S514/826 , A61K2300/00
Abstract: Provided is a powder inhalant comprising 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide and methods of using the same.
Abstract translation: 提供了包含3（R） - （2-羟基-2,2-二噻吩-2-基乙酰氧基）-1-（3-苯氧基丙基）-1-氮鎓双环[2.2.2]辛烷溴化物的粉末吸入剂和使用 相同。
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公开(公告)号：US10588895B2
公开(公告)日：2020-03-17
申请号：US16045333
申请日：2018-07-25
Applicant: ALMIRALL, S.A.
IPC: A61K31/439 , A61K31/4745 , A61K31/56 , A61K45/06 , C07D453/02 , A61K9/00 , A61K47/26
Abstract: Provided is a method for treating chronic obstructive pulmonary disease or chronic bronchitis, or inhibiting bronchospasm, which method comprises use of a powder inhaler to administer to a human patient in need of such treatment an effective amount of a powder inhalant, wherein the powder inhalant comprises 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide.
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Patent Agency Ranking
6.发明授权公开(公告)号：US09757383B2
公开(公告)日：2017-09-12
申请号：US14956767
申请日：2015-12-02
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: A61K31/538 , C07D403/12 , C07D413/14 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/4178 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D413/12 , C07D417/12 , A61K31/4184
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
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7.发明授权Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities 有权具有二肾上腺素能激动剂和M3毒蕈碱拮抗剂活性的环己胺衍生物公开(公告)号：US09233108B2
公开(公告)日：2016-01-12
申请号：US14357344
申请日：2012-11-09
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: C07D215/00 , A61K31/58 , A61K31/4709 , C07D403/12 , C07D413/14 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/4178 , A61K31/423 , A61K31/428 , A61K31/538 , A61K45/06 , C07D263/58 , C07D401/12 , C07D413/12 , C07D417/12
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。
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8.发明申请NEW CYCLOHEXYLAMINE DERIVATIVES HAVING beta2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES 有权具有β2ADRENERGIC AGONIST和M3 MUSCARINIC ANTAGONIST活动的新CYCLOHEXYLAMINE衍生物公开(公告)号：US20150306089A9
公开(公告)日：2015-10-29
申请号：US14357344
申请日：2012-11-09
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: A61K31/4709 , A61K45/06 , C07D401/12 , C07D409/12 , C07D413/14 , A61K31/428 , A61K31/4178 , C07D263/58 , A61K31/423 , A61K31/538 , C07D417/14 , C07D413/12 , C07D417/12
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。
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9.发明授权公开(公告)号：US09333195B2
公开(公告)日：2016-05-10
申请号：US14712866
申请日：2015-05-14
Applicant: ALMIRALL, S.A.
IPC: A61K31/439 , A61K31/56 , A61K31/4745 , A61K45/06 , C07D453/02 , A61K9/00 , A61K47/26
CPC classification number: A61K31/439 , A61K9/0073 , A61K9/0075 , A61K31/4745 , A61K31/56 , A61K45/06 , A61K47/26 , C07D453/02 , Y10S514/826 , A61K2300/00
Abstract: Provided is a powder inhalant comprising 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane wherein an anion X− is associated with the positive charge of the nitrogen atom and wherein X− is a pharmaceutically acceptable anion of a mono- or polyvalent acid.
Abstract translation: 提供了包含3（R） - （2-羟基-2,2-二噻吩-2-基乙酰氧基-1-（3-苯氧基丙基）-1-氮鎓双环[2.2.2]辛烷的粉末吸入剂，其中阴离子X-相关联 具有氮原子的正电荷，并且其中X是单价或多价酸的药学上可接受的阴离子。
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10.发明申请NEW CYCLOHEXYLAMINE DERIVATIVES HAVING beta2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES 有权具有β2ADRENERGIC AGONIST和M3 MUSCARINIC ANTAGONIST活动的新CYCLOHEXYLAMINE衍生物公开(公告)号：US20140378421A1
公开(公告)日：2014-12-25
申请号：US14357344
申请日：2012-11-09
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: A61K31/4709 , A61K45/06 , C07D401/12 , C07D409/12 , C07D413/14 , A61K31/428 , A61K31/4178 , C07D263/58 , A61K31/423 , A61K31/538 , C07D417/14 , C07D413/12 , C07D417/12
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。
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