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1.发明授权公开(公告)号：US10005771B2
公开(公告)日：2018-06-26
申请号：US15514294
申请日：2015-09-25
Applicant: Almirall, S.A.
Inventor： Carlos Puig Duran , Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quiñones
IPC: C07D453/02 , A61K31/439
CPC classification number: C07D453/02 , C07D401/12
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
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2.发明申请公开(公告)号：US20180015097A1
公开(公告)日：2018-01-18
申请号：US15668817
申请日：2017-08-04
Applicant: ALMIRALL,S.A
Inventor： Jose AIGUADE BOSCH , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: A61K31/538 , A61K31/4178 , C07D413/14 , C07D413/12 , C07D409/14 , C07D409/12 , C07D403/12 , C07D401/12 , C07D263/58 , A61K45/06 , A61K31/4709 , A61K31/428 , A61K31/423 , A61K31/4184 , C07D417/12 , C07D417/14
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
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3.发明授权公开(公告)号：US10300072B2
公开(公告)日：2019-05-28
申请号：US15668817
申请日：2017-08-04
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: C07D403/12 , A61K31/538 , C07D413/14 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/4178 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D413/12 , C07D417/12 , A61K31/4184
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
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4.发明授权Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities 有权具有β2肾上腺素能激动剂和M3毒蕈碱拮抗剂活性的环己胺衍生物公开(公告)号：US09549934B2
公开(公告)日：2017-01-24
申请号：US14956836
申请日：2015-12-02
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: A61K31/58 , A61K31/538 , C07D403/12 , C07D413/14 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/4178 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D413/12 , C07D417/12 , A61K31/4184
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
Abstract translation: 本发明涉及具有β2肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。
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Patent Agency Ranking
5.发明申请NEW CYCLOHEXYLAMINE DERIVATIVES HAVING BETA 2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES 审中-公开具有BETA 2 ADRENERGIC AGONIST和M3 MUSCARINIC ANTAGONIST活动的新CYCLOHEXYLAMINE衍生物公开(公告)号：US20140303127A1
公开(公告)日：2014-10-09
申请号：US14357400
申请日：2012-11-09
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: C07D409/14 , A61K45/06 , C07D409/12 , A61K31/428 , C07D413/14 , A61K31/5377 , C07D417/14 , A61K31/4709 , A61K31/4184
CPC classification number: A61K31/4184 , A61K31/428 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。
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6.发明申请NEW CYCLOHEXYLAMINE DERIVATIVES HAVING beta2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES 有权具有β2ADRENERGIC AGONIST和M3 MUSCARINIC ANTAGONIST活动的新CYCLOHEXYLAMINE衍生物公开(公告)号：US20140378421A1
公开(公告)日：2014-12-25
申请号：US14357344
申请日：2012-11-09
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: A61K31/4709 , A61K45/06 , C07D401/12 , C07D409/12 , C07D413/14 , A61K31/428 , A61K31/4178 , C07D263/58 , A61K31/423 , A61K31/538 , C07D417/14 , C07D413/12 , C07D417/12
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。
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7.发明授权公开(公告)号：US09757383B2
公开(公告)日：2017-09-12
申请号：US14956767
申请日：2015-12-02
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: A61K31/538 , C07D403/12 , C07D413/14 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/4178 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D413/12 , C07D417/12 , A61K31/4184
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
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8.发明授权Cyclohexylamine derivatives having β2 adrenergic agonist and M3 muscarinic antagonist activities 有权具有二肾上腺素能激动剂和M3毒蕈碱拮抗剂活性的环己胺衍生物公开(公告)号：US09233108B2
公开(公告)日：2016-01-12
申请号：US14357344
申请日：2012-11-09
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: C07D215/00 , A61K31/58 , A61K31/4709 , C07D403/12 , C07D413/14 , C07D409/12 , C07D409/14 , C07D417/14 , A61K31/4178 , A61K31/423 , A61K31/428 , A61K31/538 , A61K45/06 , C07D263/58 , C07D401/12 , C07D413/12 , C07D417/12
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。
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9.发明申请NEW CYCLOHEXYLAMINE DERIVATIVES HAVING beta2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES 有权具有β2ADRENERGIC AGONIST和M3 MUSCARINIC ANTAGONIST活动的新CYCLOHEXYLAMINE衍生物公开(公告)号：US20150306089A9
公开(公告)日：2015-10-29
申请号：US14357344
申请日：2012-11-09
Applicant: ALMIRALL, S.A.
Inventor： Jose Aiguade Bosch , Silvia Gual Roig , Maria Prat Quinones , Carlos Puig Duran
IPC: A61K31/4709 , A61K45/06 , C07D401/12 , C07D409/12 , C07D413/14 , A61K31/428 , A61K31/4178 , C07D263/58 , A61K31/423 , A61K31/538 , C07D417/14 , C07D413/12 , C07D417/12
CPC classification number: A61K31/538 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4709 , A61K45/06 , C07D263/58 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.
Abstract translation: 本发明涉及具有β-肾上腺素能激动剂和M3毒蕈碱拮抗剂双重活性的新化合物，含有它们的药物组合物，其制备方法及其在呼吸治疗中的用途。
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