公开(公告)号：US3562255A

公开(公告)日：1971-02-09

申请号：US3562255D

申请日：1969-04-29

Applicant: AMERICAN HOME PROD

Inventor： OLIVER DONALD W ,  WENDT GERHARD R

IPC: C07J33/00 ,  C07J75/00 ,  C07C173/00

CPC classification number: C07J33/00 ,  C07J75/00

Abstract: 13-ALKYL-17 A-AMINOPROPARGYL-17-HYDROZYGON - 4 - EN3-ONE, CYCLIC ETHYLENE THIOKETALS AND ALKANOATES, OPTIONALLY HALO-SUBSTITUTED AT C-4, (I) AND THEIR SALTS ARE USEFUL BIOCIDALLY AS TRICHOMONACIDES AND AMEBICIDES, AND PHARMACOLOGICALLY AS BRONCHODILATORS. COMPOUNDS (I) ARE PREPARED BY TREATING THE CORRESPONDING 13-ALKYL-17 A-ETHYNYL17-HYDROXYGON-4-EN-3-ONE, CYCLIC ETHYLENE THIOKETAL (II) WITH FORMALDEHYDE AND AN APPROPRIATELY-SUBSTITUTED SECONDARY AMINE.

公开(公告)号：US3707479A

公开(公告)日：1972-12-26

申请号：US3707479D

申请日：1971-07-23

Applicant: AMERICAN HOME PROD

Inventor： WENDT GERHARD R ,  OLIVER DONALD W

IPC: C07D333/38 ,  C07D333/48 ,  C07D63/04 ,  C07D65/02

CPC classification number: C07D333/48 ,  C07D333/38 ,  Y10S514/927

Abstract: S-OXIDES OF 4-AMINOTETRAHYDRO-2H-THIOPYRAN-4-CARBOXYLIC ACID AND 3-AMINO-TETRAHYDRO-3-THIOPHENECARBOXYLIC ACID ARE PREPARED. THE COMPOUNDS ARE INTERMEDIATES FOR THE SYNTHESIS OF NEW PENCILLINS.

公开(公告)号：US3575967A

公开(公告)日：1971-04-20

申请号：US3575967D

申请日：1969-02-05

Applicant: AMERICAN HOME PROD

Inventor： LEDIG KURT W ,  OLIVER DONALD W ,  WENDT GERHARD R

IPC: C07J41/00 ,  C07C173/10

CPC classification number: C07J41/0044

Abstract: 13-ALKYL-17A-AMINOALKYNYL- AND 17A-AMINOALKYLGONA3,5-DIENES (I) ARE USEFUL BIOCIDALLY AS AMEBICIDES, FUNGICIDES AND TRICHOMONACIDES. COMPOUNDS (I) ARE PREPARED BY (A) DEHYDRATING A CORRESPONDING 17A-AMINOALKYNYLOR -AMINOALKYL 19-NORSTERIODAL 4-EN-3-O1 (II); (B) AMINOALKYLATING A CORRESPONDING 17A-ALKYNYL 19-NORSTEROIDAL 4-EN-3-OL (III) AND THEN DEHYDRATING; OR (C) AMINOALKYLATING A CORRESPONDING 17A-ALKYNYL 19-NORSTEROIDAL 3,5DIENE (IV).

公开(公告)号：US3642842A

公开(公告)日：1972-02-15

申请号：US3642842D

申请日：1968-12-23

Applicant: AMERICAN HOME PROD

Inventor： BEGANY ALBERT J ,  LEDIG KURT W ,  OLIVER DONALD W ,  WENDT GERHARD R

IPC: C07J41/00 ,  C07J63/00 ,  C07C169/20

CPC classification number: C07J63/008 ,  C07J41/0005

Abstract: 13-ALKYL-17X-SUBSTITUTED - 17 - HYDROXYGON-4-EN-3-ONE, SEMICARBAXONES AND THIOSEMICARBAZONES, $4,6,8(14),9 AND 11 DEHYDRO ANALOGS, AND D-HOMO ANALOGS THEREOF, OPTIONALLY SUBSTITUTED BY METHYL AT POSTIONS 1,2,4,6,7 AND 11, ALKANOYL AT POSTION 17, BY ALKYL, ARYL, ARYLALKYL AND ALKYLARYL IN THE SEMICARBAZONE OR THIOSEMICARBAZONE GROUP, AND BY A 17X-ALKYL GROUP OR BY METHYL OR HAOLGEN IN A 17X-ETHYNYL GROUP (I) ARE PROVIDED BY CONDENSING THE CORRESPONDING 3-KETOSTEROID (II) WITH THE CORRESPONDING SEMICARBAZIDE OR THIOSEMICARBAZIDE (III). COMPOUNDS (I) ARE PHARMACOLOGICALLY ACTIVE IN WARM BLOODED LOWER ANIMALS AS BRONOCHODILATORS AND AS ANTI-INFLAMMATORY AGENTS.

公开(公告)号：US3577445A

公开(公告)日：1971-05-04

申请号：US3577445D

申请日：1968-12-23

Applicant: AMERICAN HOME PROD

Inventor： OLIVER DONALD W ,  WENDT GERHARD R

IPC: C07C169/08

CPC classification number: C07J75/00

Abstract: NOVEL 19-NORSTEROIDAL 3-CHLORO-3,5-DIENES, PARTICULARLY, 3-CHLORO-13-ETHYL-17A-ETHYNYL(OR CHLOROETHYNYL)GONA-3,5DIEN-17-OLS (I) ARE PROVIDED BY CHLORO/ENOLIZING THE CORRESPONDING GON-4-EN-3-ONES (II) WITH A REAGENT SUCH AS OXALYL CHLORIDE. COMPOUNDS I ARE PHARMACOLOGICALLY ACTIVE AS BRONOCHODILATORS AND BIOCIDALLY-ACITVE, AS BACTERICIDES.

公开(公告)号：US3553213A

公开(公告)日：1971-01-05

申请号：US3553213D

申请日：1969-03-17

Applicant: AMERICAN HOME PROD

Inventor： OLIVER DONALD W ,  WENDT GERHARD R

IPC: C07J41/00 ,  C07J43/00 ,  C07J75/00 ,  C07C173/10

CPC classification number: C07J43/00 ,  C07J41/00 ,  C07J75/00

Abstract: 13 - ALKYL - 17A - AMINOALKYNYL - 3 - CHLOROGONA - 3,5DIEN-17-OLS AND 17-ALKANOATES (1) AND THEIR SALTS ARE USEFUL AS TRICHOMONACIDES, FUNGICIDES, AMEBICIDES AND BACTERICIDES. COMPOUNDS (I) ARE PREPARED BY TREATING THE CORRESPONDING 13 - ALKYL - 3 - CHLORO - 17A - ETHYNLGONA-3,5DIEN-17-OL OR 17-ALKANOTE (II) WITH FORMALDEHYDE AND AN APPROPRIATELY-SUBSTITUTED SECONDARY AMINE.