公开(公告)号：US12134652B2

公开(公告)日：2024-11-05

申请号：US17111453

申请日：2020-12-03

Applicant: AMGEN INC.

Inventor： Thomas C. Boone ,  David W. Brankow ,  Colin V. Gegg, Jr. ,  Shaw-Fen Sylvia Hu ,  Chadwick T. King ,  Hsieng Sen Lu ,  Licheng Shi ,  Cen Xu

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  G01N33/53 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US12122841B2

公开(公告)日：2024-10-22

申请号：US17111442

申请日：2020-12-03

Applicant: AMGEN INC.

Inventor： Thomas C. Boone ,  David W. Brankow ,  Colin V. Gegg, Jr. ,  Shaw-Fen Sylvia Hu ,  Chadwick T. King ,  Hsieng Sen Lu ,  Licheng Shi ,  Cen Xu

IPC: C07K16/28 ,  A61K39/395 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63 ,  A61K39/00

CPC classification number: C07K16/2869 ,  A61K39/39533 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US09862771B2

公开(公告)日：2018-01-09

申请号：US14752493

申请日：2015-06-26

Applicant: AMGEN INC.

Inventor： Thomas C. Boone ,  David W. Brankow ,  Colin V. Gegg, Jr. ,  Shaw-Fen Sylvia Hu ,  Chadwick T. King ,  Hsieng Sen Lu ,  Licheng Shi ,  Cen Xu

IPC: A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2869 ,  A61K39/395 ,  A61K39/39533 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.