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公开(公告)号：US20220144920A1
公开(公告)日：2022-05-12
申请号：US17420231
申请日：2020-01-02
Applicant: AMGEN INC.
Inventor： Jennitte LeAnn STEVENS , Deniz TEMEL , Bram ESTES , Neeraj Jagdish AGRAWAL
IPC: C07K16/00
Abstract: Presented herein are methods directed to engineering monoclonal antibodies and antibody variants to improve stability and their production in culture. Specifically, the monoclonal antibodies can be engineered at heavy chain residue 56 (AHo numbering) to a glycine, alanine, or serine, and/or engineered at position 80 (AHo) to be a hydrophobic residue such as alanine, isoleucine, phenylalanine, leucine, methionine, or valine.
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