公开(公告)号：US20180161279A1

公开(公告)日：2018-06-14

申请号：US15840908

申请日：2017-12-13

Applicant: AMGEN INC.

Inventor： John Inn CHUNG ,  Armen PIRJANIAN ,  Fernando Antonio ALVAREZ-NUNEZ ,  Jeffrey Michael KATZ ,  Dominick Paul DAURIO ,  Stevedat LA ,  Michael T. KENNEDY

IPC: A61K9/20 ,  A61K9/00 ,  A61K9/28 ,  A61K38/06

CPC classification number: A61K9/2031 ,  A61K9/0065 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2086 ,  A61K9/28 ,  A61K38/06

Abstract: This disclosure features gastro-retentive (GR) modified release pharmaceutical dosage forms (e.g., solid dosage forms, e.g., tablets, e.g., bilayer tablets) that are useful for the oral administration of oprozomib, or a pharmaceutically acceptable salt thereof, to a human or animal subject as well as methods of making and using the dosage form.

公开(公告)号：US20240226020A1

公开(公告)日：2024-07-11

申请号：US18558827

申请日：2022-05-05

Applicant: AMGEN INC.

Inventor： Fernando Antonio ALVAREZ-NUNEZ ,  Jiemin BAO ,  Sai Prasanth CHAMARTHY ,  Dominick Paul DAURIO ,  Naga DUGGIRALA ,  Brett E. HOUK ,  Yuan-Hon KIANG ,  Angela OLSOFSKY ,  Namita SAWANT

IPC: A61K9/28 ,  A61K9/00 ,  A61K9/20 ,  A61K31/519

CPC classification number: A61K9/284 ,  A61K9/0095 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/519

Abstract: The disclosure provides formulations comprising sotorasib (1), a diluent, a disintegrant and a lubricant.