公开(公告)号：US20240226020A1

公开(公告)日：2024-07-11

申请号：US18558827

申请日：2022-05-05

Applicant: AMGEN INC.

Inventor： Fernando Antonio ALVAREZ-NUNEZ ,  Jiemin BAO ,  Sai Prasanth CHAMARTHY ,  Dominick Paul DAURIO ,  Naga DUGGIRALA ,  Brett E. HOUK ,  Yuan-Hon KIANG ,  Angela OLSOFSKY ,  Namita SAWANT

IPC: A61K9/28 ,  A61K9/00 ,  A61K9/20 ,  A61K31/519

CPC classification number: A61K9/284 ,  A61K9/0095 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/519

Abstract: The disclosure provides formulations comprising sotorasib (1), a diluent, a disintegrant and a lubricant.

公开(公告)号：US20230090391A1

公开(公告)日：2023-03-23

申请号：US17798531

申请日：2021-02-10

Applicant: Amgen Inc.

Inventor： Mingda BI ,  Yuan-Hon KIANG ,  Hao LOU

IPC: A61K31/496 ,  A61K9/28 ,  A61K9/20

Abstract: Provided herein are tablet formulations comprising a core comprising omecamtiv mecarbil, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable hydrate of a pharmaceutically acceptable salt thereof; a filler; a binder; a glidant; and a lubricant; and a film coating on the core, the film coating comprising a modified-release polymer and a pore former. Also provided is a process for making a tablet formulation and a method of treating cardiovascular conditions, such as heart failure, using the tablet formulation.