公开(公告)号：US12297260B2

公开(公告)日：2025-05-13

申请号：US17015212

申请日：2020-09-09

Applicant: AMGEN INC.

Inventor： William Gleason Richards ,  Hsieng Sen Lu ,  Hua Zhu Ke ,  Chaoyang Li ,  Frederick W. Jacobsen

IPC: C07K16/18 ,  A61K39/395 ,  C07K16/22 ,  A61K39/00

Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.

公开(公告)号：US10800839B2

公开(公告)日：2020-10-13

申请号：US15841065

申请日：2017-12-13

Applicant: Amgen Inc.

Inventor： William Gleason Richards ,  Hsieng Sen Lu ,  Hua Zhu Ke ,  Chaoyang Li ,  Frederick W. Jacobsen

IPC: C07K16/18 ,  C07K16/22 ,  A61K39/395 ,  A61K39/00

Abstract: The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.

公开(公告)号：US09353174B2

公开(公告)日：2016-05-31

申请号：US14185590

申请日：2014-02-20

Applicant: AMGEN INC.

Inventor： Christopher J. Paszty ,  Hsieng Sen Lu

IPC: C12N15/13 ,  C12N15/63 ,  C07K16/18 ,  C07K14/51 ,  C07K16/22 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K14/51 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/63

Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.

Abstract translation: 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能结合硬化蛋白的抗体。

公开(公告)号：US12122841B2

公开(公告)日：2024-10-22

申请号：US17111442

申请日：2020-12-03

Applicant: AMGEN INC.

Inventor： Thomas C. Boone ,  David W. Brankow ,  Colin V. Gegg, Jr. ,  Shaw-Fen Sylvia Hu ,  Chadwick T. King ,  Hsieng Sen Lu ,  Licheng Shi ,  Cen Xu

IPC: C07K16/28 ,  A61K39/395 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63 ,  A61K39/00

CPC classification number: C07K16/2869 ,  A61K39/39533 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US09862771B2

公开(公告)日：2018-01-09

申请号：US14752493

申请日：2015-06-26

Applicant: AMGEN INC.

Inventor： Thomas C. Boone ,  David W. Brankow ,  Colin V. Gegg, Jr. ,  Shaw-Fen Sylvia Hu ,  Chadwick T. King ,  Hsieng Sen Lu ,  Licheng Shi ,  Cen Xu

IPC: A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2869 ,  A61K39/395 ,  A61K39/39533 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US20140248666A1

公开(公告)日：2014-09-04

申请号：US14185590

申请日：2014-02-20

Applicant: Amgen Inc.

Inventor： Christopher J. Paszty ,  Hsieng Sen Lu

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K14/51 ,  C07K16/22 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/63

Abstract: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.

Abstract translation: 提供了与硬骨素蛋白表位有关的组合物和方法，以及硬骨素结合剂，例如能够结合硬化蛋白的抗体。

公开(公告)号：US12134652B2

公开(公告)日：2024-11-05

申请号：US17111453

申请日：2020-12-03

Applicant: AMGEN INC.

Inventor： Thomas C. Boone ,  David W. Brankow ,  Colin V. Gegg, Jr. ,  Shaw-Fen Sylvia Hu ,  Chadwick T. King ,  Hsieng Sen Lu ,  Licheng Shi ,  Cen Xu

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  G01N33/53 ,  C12N5/10 ,  C12N15/00 ,  C12N15/63

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

公开(公告)号：US20150322144A1

公开(公告)日：2015-11-12

申请号：US14663377

申请日：2015-03-19

Applicant: AMGEN INC.

Inventor： Huiquan Han ,  Taruna Arora ,  Qing Chen ,  Hsieng Sen Lu ,  Xiaolan Zhou

IPC: C07K16/22

CPC classification number: C07K16/26 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/466

Abstract: There are disclosed selective myostatin antagonists (including antibodies), nucleic acids encoding them, and methods of making and using them.

Abstract translation: 公开了选择性肌生成抑制素拮抗剂（包括抗体），编码它们的核酸，以及制备和使用它们的方法。