公开(公告)号：US20240409557A1

公开(公告)日：2024-12-12

申请号：US18657114

申请日：2024-05-07

Applicant: AMGEN INC.

Inventor： Kevin Lloyd GREENMAN ,  Alexander J. Pickrell ,  Kexue LI ,  Albert K. AMEGADZIE ,  Hui-Ling WANG ,  Nicholas Anthony WEIRES ,  John G. ALLEN ,  Matthew P. BOURBEAU

IPC: C07D519/00 ,  A61K31/437 ,  A61K31/519 ,  A61P1/04

Abstract: The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A). Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).