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公开(公告)号：US11634502B2
公开(公告)日：2023-04-25
申请号：US14774320
申请日：2014-03-13
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Luis G. Borges , Mark L. Michaels
Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.
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Patent Agency Ranking
公开(公告)号：US20230212318A1
公开(公告)日：2023-07-06
申请号：US17727316
申请日：2022-04-22
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Mark L. Michaels , Patrick Baeuerle
IPC: C07K16/46 , C07K14/725 , C07K16/28 , C07K16/32
CPC classification number: C07K16/468 , C07K14/7051 , C07K16/32 , C07K16/2809 , C07K2317/31 , C07K2317/52 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2317/565 , C07K2317/622 , C07K2319/00 , C07K2319/50
Abstract: Described herein are protease-activatable proteins (PABPs), which, when activated, can mediate cytolysis of target cells by effector cells. Also provided are nucleic acids encoding such PABPs and methods of making and using PABPs.
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公开(公告)号：US20170247476A1
公开(公告)日：2017-08-31
申请号：US15513011
申请日：2015-09-24
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Mark L. Michaels , Patrick Baeuerle
IPC: C07K16/46 , C07K16/28 , C07K16/32 , C07K14/725
CPC classification number: C07K16/468 , C07K14/7051 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/92 , C07K2319/00 , C07K2319/50
Abstract: Described herein are protease-activatable proteins (PABPs), which, when activated, can mediate cytolysis of target cells by effector cells. Also provided are nucleic acids encoding such PABPs and methods of making and using PABPs.
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公开(公告)号：US20230077648A1
公开(公告)日：2023-03-16
申请号：US17722724
申请日：2022-04-18
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Luis G. Borges , Mark L. Michaels
Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.
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公开(公告)号：US20200071425A1
公开(公告)日：2020-03-05
申请号：US16383115
申请日：2019-04-12
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Luis G. Borges , Mark L. Michaels
Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.
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公开(公告)号：US20160115241A1
公开(公告)日：2016-04-28
申请号：US14774320
申请日：2014-03-13
Applicant: AMGEN INC.
Inventor： Wei Yan , Martin J. Pentony , Luis G. Borges , Mark L. Michaels
CPC classification number: C07K16/30 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/565 , C07K2317/60 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2317/94
Abstract: Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.
Abstract translation: 本文提供了可以通过免疫效应细胞介导靶细胞的细胞溶解的异二聚体双特异性抗体，编码这种抗体的核酸，制备此类抗体的方法以及使用这种抗体的方法。 这些抗体包含两个不同的多肽链，每条链包含两个免疫球蛋白可变区和任选的半衰期延长部分。
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