公开(公告)号：US11918650B2

公开(公告)日：2024-03-05

申请号：US15972489

申请日：2018-05-07

Applicant: AMGEN INC.

Inventor： Jeff Abel ,  Lingwen Cui ,  Devrishi Goswami ,  Joon Huh ,  Bharadwaj Jagannathan ,  Sekhar Kanapuram ,  Arnold McAuley ,  Michael Schneider ,  Ananthakrishnan G. Sethuraman ,  Michael Treuheit ,  Jun Zhang

IPC: A61K39/395 ,  A61K9/00 ,  A61K9/08 ,  A61K9/19 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/24 ,  A61K47/26 ,  C07K16/28 ,  C07K16/46 ,  A61J1/05 ,  A61J1/10 ,  A61K39/00

CPC classification number: A61K39/39591 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K39/3955 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/183 ,  A61K47/24 ,  A61K47/26 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2863 ,  C07K16/468 ,  A61J1/05 ,  A61J1/10 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/627 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/41 ,  C07K2317/569

Abstract: The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 μg/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.

公开(公告)号：US20240028790A1

公开(公告)日：2024-01-25

申请号：US18256442

申请日：2021-12-22

Applicant: AMGEN INC. ,  Board of Regents, The University of Texas System

Inventor： Tian Wu ,  Michael Schneider ,  Ryan Khalaf ,  Hugh Smyth ,  Ashlee Brunaugh ,  Li Ding

IPC: G06F30/20

CPC classification number: G06F30/20

Abstract: A forecasting modeling computing system includes a processors and a memory including a set of computer-executable instructions that, when executed by the processor, cause the forecasting modeling computing system to receive design parameters, determine a predicted median particle size, identify a predictive quadratic model, and display a response surface visualization. A computer-implemented method includes receiving design parameters, determining a predicted median particle size, identifying a predictive quadratic model; and display a response surface visualization.

公开(公告)号：US20190151448A1

公开(公告)日：2019-05-23

申请号：US15972489

申请日：2018-05-07

Applicant: AMGEN INC.

Inventor： Jeff Abel ,  Lingwen Cui ,  Devrishi Goswami ,  Joon Huh ,  Bharadwaj Jagannathan ,  Sekhar Kanapuram ,  Arnold McAuley ,  Michael Schneider ,  Ananthakrishnan G. Sethuraman ,  Michael Treuheit ,  Jun Zhang

IPC: A61K39/395 ,  C07K16/28 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/12 ,  A61K47/26 ,  A61K47/18 ,  C07K16/46

Abstract: The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 μg/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.