公开(公告)号：US12083176B2

公开(公告)日：2024-09-10

申请号：US17560402

申请日：2021-12-23

申请人： Sanofi Biotechnology

发明人： Corinne Hanotin ,  Laurence Bessac ,  Umesh Chaudhari

IPC分类号： C07K16/40 ,  A61K39/395 ,  A61P3/06 ,  A61J1/05 ,  A61K31/215 ,  A61K31/366 ,  A61K31/404 ,  A61K31/435 ,  A61K31/47 ,  A61K31/505 ,  A61K39/00 ,  A61K45/06 ,  C07K14/47

CPC分类号： A61K39/3955 ,  A61P3/06 ,  C07K16/40 ,  A61J1/05 ,  A61K31/215 ,  A61K31/366 ,  A61K31/404 ,  A61K31/435 ,  A61K31/47 ,  A61K31/505 ,  A61K39/395 ,  A61K2039/505 ,  A61K2039/545 ,  A61K45/06 ,  C07K14/4703 ,  C07K2317/21 ,  C07K2317/76

摘要： The present invention relates to methods for treating diseases or conditions in which proprotein convertase subtilisin/kexin type 9 (PCSK9) expression or activity causes an impact by administration of PCSK9-specific antibodies or antigen-binding fragments thereof and preferably by additional administration of an inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase). The present invention further relates to PCSK9-specific antibodies or antigen-binding fragments thereof for use in the treatment of diseases or conditions in which PCSK9 expression or activity causes an impact. The present invention also relates to articles of manufacture comprising packaging material, PCSK9-specific antibodies or antigen-binding fragments thereof, and a label or packaging insert indicating which groups of patients can be treated with said antibodies or fragments, which groups of patients must not be treated with said antibodies or fragments, and which dosage regimen should be used. The present invention further relates to methods of testing the efficacy of PCSK9-specific antibodies or antigen-binding fragments thereof for the treatment of certain diseases or conditions and for the treatment of specific sub-groups of patients.

公开(公告)号：US20240269041A1

公开(公告)日：2024-08-15

申请号：US18630118

申请日：2024-04-09

申请人： Haemonetics Corporation

发明人： Yuri Zimenkov ,  Bruno Piazzarolo ,  Dinesh Kommireddy ,  Shinji Yue ,  Tim Fallon

IPC分类号： A61J1/16 ,  A61J1/05 ,  A61M1/34

CPC分类号： A61J1/165 ,  A61J1/05 ,  A61M1/3496

摘要： A blood component cooling container includes a body portion having a proximal end and a distal end. The body portion defines an interior volume, and includes a plurality of cooling vanes that extend radially outward from the body portion. The cooling vanes increase the external surface area of the blood component cooling container. The blood component cooling container also has an opening within the body portion and configured to receive collected plasma.

公开(公告)号：US12042467B2

公开(公告)日：2024-07-23

申请号：US17721830

申请日：2022-04-15

申请人： NOVARTIS AG

发明人： Andrew Bryant ,  Alain Schmidlin ,  Daniel Latham ,  Gabriel Iobbi ,  Arun Venkatasubramanian ,  Thomas Richard Redman ,  Timothy Duncan Wooller ,  Franck Rubiconi ,  Robert George Milner ,  Richard Andrew Hall ,  Symon Cotton ,  Simon Peter Attard

IPC分类号： A61J1/14 ,  A61J1/05 ,  B01L3/00 ,  H04B5/77

CPC分类号： A61J1/1468 ,  A61J1/05 ,  B01L3/545 ,  H04B5/77 ,  A61J2205/60

摘要： A pharmaceutical container may include a cylindrical hollow container body (100) defining a hollow chamber (111) to receive a pharmaceutical liquid, the container body (100) including a portion on a sidewall (121) of the container body (100), wherein the portion has a longitudinal extension along the longitudinal axis of the container body (100) and a circumferential extension along the circumference of the container body (100), thereby forming a window (122) through the sidewall (121) of the container body (100) into the hollow chamber (111), the window (122) comprising two long edges (124) and two short edges (125), and a Near Field Communication (NFC) antenna (110) arranged on the outer surface (120) of the sidewall (121) of the container, the antenna (110) including one or a plurality of nested antenna windings (150), each of them surrounding an interior periphery (140) including a substantially longitudinal portion (141) arranged along the two long edges (124) of the window (122), and a substantially circumferential portion (142) arranged mainly around the sidewall (121) of the container body (100) and at least partially along a first one of the two short edges (125) of the window (122) opposite to a second one of the two short edges (125) of the window (122).

公开(公告)号：US20240208713A1

公开(公告)日：2024-06-27

申请号：US18283876

申请日：2022-03-24

申请人： DAI NIPPON PRINTING CO., LTD.

发明人： Takuma BABA ,  Hiroyuki KOBORI ,  Reiko SHIMIZU ,  Hisashi AIZAWA ,  Kazuhiro TAKUSHIMA

IPC分类号： B65D81/26 ,  A61J1/05 ,  B65B31/04 ,  B65D41/28 ,  B65D51/00 ,  B65D65/38 ,  B65D77/04 ,  B65D81/20

CPC分类号： B65D81/268 ,  A61J1/05 ,  B65B31/04 ,  B65D41/28 ,  B65D51/002 ,  B65D65/38 ,  B65D77/04 ,  B65D81/20 ,  B65D81/264 ,  B65D2251/0015 ,  B65D2251/0075 ,  B65D2565/387 ,  B65D2565/388

摘要： A liquid-containing combination container includes a first container that contains a liquid and that has oxygen permeability, a second container that contains the first container and that has an oxygen barrier property, and an oxygen absorber that absorbs oxygen in the second container. Pressure in the first container is 1 atm or less.

公开(公告)号：US20240113862A1

公开(公告)日：2024-04-04

申请号：US18540067

申请日：2023-12-14

申请人： Inveniam Capital Partners, Inc.

发明人： Paul Snow

IPC分类号： H04L9/06 ,  A61B1/018 ,  A61B1/273 ,  A61J1/05 ,  A61J1/06 ,  A61K49/00 ,  A61L24/00 ,  A61L24/04 ,  A61L31/06 ,  A61M5/00 ,  A61M5/178 ,  A61M5/32 ,  A61M39/10 ,  G06F12/0815 ,  G06F16/23 ,  G06F16/2458 ,  G06F21/60 ,  H04L9/08 ,  H04L9/32

CPC分类号： H04L9/0637 ,  A61B1/018 ,  A61B1/273 ,  A61J1/05 ,  A61J1/06 ,  A61K49/006 ,  A61L24/001 ,  A61L24/046 ,  A61L31/06 ,  A61M5/007 ,  A61M5/178 ,  A61M5/329 ,  A61M39/10 ,  G06F12/0815 ,  G06F16/2379 ,  G06F16/2465 ,  G06F21/602 ,  H04L9/0643 ,  H04L9/0869 ,  H04L9/3218 ,  H04L9/3236 ,  H04L9/3239 ,  A61L2300/442 ,  A61L2400/06 ,  G06F2212/1016 ,  G06F2216/03 ,  H04L9/50

摘要： Blockchain environments may mix-and-match different encryption, difficulty, and/or proof-of-work schemes when mining blockchain transactions. Each encryption, difficulty, and/or proof-of-work scheme may be separate, stand-alone programs, files, or third-party services. Blockchain miners may be agnostic to a particular coin's or network's encryption, difficulty, and/or proof-of-work schemes, thus allowing any blockchain miner to process or mine data in multiple blockchains. GPUs, ASICs, and other specialized processing hardware components may be deterred by forcing cache misses, cache latencies, and processor stalls. Hashing, difficulty, and/or proof-of-work schemes require less programming code, consume less storage space/usage in bytes, and execute faster. Blockchain mining schemes may further randomize byte or memory block access, further improve cryptographic security.

公开(公告)号：US11943334B2

公开(公告)日：2024-03-26

申请号：US17942270

申请日：2022-09-12

申请人： Inveniam Capital Partners, Inc.

发明人： Paul Snow

IPC分类号： H04L9/06 ,  A61B1/018 ,  A61B1/273 ,  A61J1/05 ,  A61J1/06 ,  A61K49/00 ,  A61L24/00 ,  A61L24/04 ,  A61L31/06 ,  A61M5/00 ,  A61M5/178 ,  A61M5/32 ,  A61M39/10 ,  G06F12/0815 ,  G06F16/23 ,  G06F16/2458 ,  G06F21/60 ,  H04L9/08 ,  H04L9/32 ,  H04L9/00

CPC分类号： H04L9/0637 ,  A61B1/018 ,  A61B1/273 ,  A61J1/05 ,  A61J1/06 ,  A61K49/006 ,  A61L24/001 ,  A61L24/046 ,  A61L31/06 ,  A61M5/007 ,  A61M5/178 ,  A61M5/329 ,  A61M39/10 ,  G06F12/0815 ,  G06F16/2379 ,  G06F16/2465 ,  G06F21/602 ,  H04L9/0643 ,  H04L9/0869 ,  H04L9/3218 ,  H04L9/3236 ,  H04L9/3239 ,  A61L2300/442 ,  A61L2400/06 ,  G06F2212/1016 ,  G06F2216/03 ,  H04L9/50

摘要： Blockchain environments may mix-and-match different encryption, difficulty, and/or proof-of-work schemes when mining blockchain transactions. Each encryption, difficulty, and/or proof-of-work scheme may be separate, stand-alone programs, files, or third-party services. Blockchain miners may be agnostic to a particular coin's or network's encryption, difficulty, and/or proof-of-work schemes, thus allowing any blockchain miner to process or mine data in multiple blockchains. GPUs, ASICs, and other specialized processing hardware components may be deterred by forcing cache misses, cache latencies, and processor stalls. Hashing, difficulty, and/or proof-of-work schemes require less programming code, consume less storage space/usage in bytes, and execute faster. Blockchain mining schemes may further randomize byte or memory block access, further improve cryptographic security.

公开(公告)号：US20240074944A1

公开(公告)日：2024-03-07

申请号：US18341079

申请日：2023-06-26

申请人： SiO2 Medical Products, Inc.

发明人： Christopher Weikart ,  Becky L. Clark ,  Adam Stevenson ,  John T. Felts

IPC分类号： A61J1/14 ,  A61J1/00 ,  A61J1/03 ,  A61J1/05 ,  A61L31/04 ,  A61L31/08 ,  A61L31/14 ,  A61L31/16 ,  A61M5/31 ,  B65D25/14 ,  C23C16/02 ,  C23C16/04 ,  C23C16/40 ,  C23C16/455 ,  C23C16/50 ,  G01N27/22 ,  G01N33/53 ,  G01N33/543 ,  G01N33/74

CPC分类号： A61J1/1468 ,  A61J1/00 ,  A61J1/035 ,  A61J1/05 ,  A61L31/04 ,  A61L31/08 ,  A61L31/088 ,  A61L31/143 ,  A61L31/16 ,  A61M5/3129 ,  B65D25/14 ,  C23C16/029 ,  C23C16/045 ,  C23C16/401 ,  C23C16/45523 ,  C23C16/50 ,  G01N27/227 ,  G01N33/5308 ,  G01N33/5438 ,  G01N33/74 ,  A61L2420/02 ,  A61L2420/08 ,  A61M2005/3131 ,  A61M2205/0238 ,  G01N2333/62 ,  G01N2800/042

摘要： An article or vessel is described including a vessel surface and a coating set comprising at least one tie coating, at least one barrier coating, and at least one pH protective coating. For example, the coating set can comprise a tie coating, a barrier coating, a pH protective coating and a second barrier coating; and in the presence of a fluid composition, the fluid contacting surface is the barrier coating or layer. The respective coatings can be applied by PECVD of a polysiloxane precursor. Such vessels can have a coated interior portion containing a fluid with a pH of 4 to 8. The barrier coating prevents oxygen from penetrating into the thermoplastic vessel, and the tie coating and pH protective coating together protect the barrier layer from the contents of the vessel. The second barrier coating is comparable to glass surface if needed.

公开(公告)号：US11883531B2

公开(公告)日：2024-01-30

申请号：US16926881

申请日：2020-07-13

申请人： ILTOO PHARMA

发明人： Jérémie Mariau ,  Michel Thiry

IPC分类号： A61K38/20 ,  A61K9/19 ,  A61K9/08 ,  A61K9/00 ,  A61K47/20 ,  A61K47/00 ,  A61K47/02 ,  A61J1/05

CPC分类号： A61K9/08 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/2013 ,  A61K47/00 ,  A61K47/02 ,  A61K47/20 ,  A61J1/05

摘要： The invention relates to a liquid pharmaceutical composition of Il-2 and its use in the treatment of auto-immune and inflammatory disorders. Methods for preparing said composition and delivery devices filled with said composition are also described.

公开(公告)号：US11794961B2

公开(公告)日：2023-10-24

申请号：US17597336

申请日：2020-07-01

申请人： Alejandro Gamboa Burgos

发明人： Alejandro Gamboa Burgos

IPC分类号： B65D47/18 ,  B65D47/20 ,  B65D47/32 ,  B05B11/04 ,  B05B11/00 ,  A61F9/00 ,  A61J1/05

CPC分类号： B65D47/32 ,  A61F9/00 ,  A61J1/05 ,  B05B11/0044 ,  B05B11/04 ,  B05B11/047 ,  B65D47/18 ,  B65D47/20

摘要： A liquid dispensing device includes a multifunction membrane valve that, in addition to allowing the dispensing of drops with a drop-check mechanism, ensures and isolates the passage of the air to be filtered so that it does not contaminate the liquid in the interior of the dispensing device; it has a reduced number of parts; it facilitates proper assembly by counter pressure, without the need for threads or complex coupling elements; it avoids the need for rotational alignment when assembling the parts, among other advantages.

公开(公告)号：US20230277415A1

公开(公告)日：2023-09-07

申请号：US18316308

申请日：2023-05-12

申请人： SIO2 MEDICAL PRODUCTS, INC.

发明人： Michael Bucholtz ,  Matthew Nagy

IPC分类号： A61J1/05 ,  A61J1/14 ,  B65D77/04 ,  B65D65/42 ,  B29C45/26

CPC分类号： A61J1/05 ,  A61J1/1412 ,  A61J1/1468 ,  B65D77/0493 ,  B65D65/42 ,  B29C45/2612 ,  B29L2031/712

摘要： Disclosed is a vial having an external base and an external sidewall extending up from the external base. The external sidewall narrows at an upper section of the vial to form a neck. The neck leads to a rim surrounding an opening providing access to a product compartment. The external base, the external sidewall, the neck and optionally the rim together define an outer profile of the vial. The outer profile is preferably round and symmetrical about a central axis. The vial further includes an internal sidewall that is spaced radially inward relative to the external sidewall such that a void exists between the internal sidewall and the external sidewall. The internal sidewall preferably extends from an internal portion of the neck, downward to an internal base. The internal sidewall and internal base form an enclosure that defines the product compartment.