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公开(公告)号：US20160168213A1
公开(公告)日：2016-06-16
申请号：US14908459
申请日：2014-07-31
Applicant: AMGEN INC.
Inventor： Yumei XIONG , Yi ZHANG , Jackie Z. SHENG , Agnes Eva HAMBURGER , Murielle VENIANT-ELLISON , Grant SHIMAMOTO , Xiaoshan MIN , Zhulun WANG , Jie TANG , Gunasekaran KANNAN , Marissa MOCK , Kenneth WALKER
IPC: C07K14/475
CPC classification number: C07K14/475 , C07K2319/30
Abstract: Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
Abstract translation: 提供了包含GDF15的构建体及其突变体。 在各种实施方案中，包含GDF15及其突变体的构建体可用于治疗或改善代谢紊乱。 在各种实施方案中，代谢疾病或病症是2型糖尿病，肥胖症，血脂异常，升高的葡萄糖水平，升高的胰岛素水平和糖尿病性肾病。
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公开(公告)号：US20180311372A1
公开(公告)日：2018-11-01
申请号：US15872841
申请日：2018-01-16
Applicant: AMGEN INC.
Inventor： Yuan CHENG , Chawita NETIROJJANAKUL , Jerry Ryan HOLDER , Bin WU , James R. FALSEY , Bradley J. HERBERICH , Kelvin SHAM , Leslie P. MIRANDA , Shu-Chen LU , Murielle VENIANT-ELLISON , Shanaka STANISLAUS , Junming YIE , Jing XU
CPC classification number: C07K16/28 , A61K39/395 , A61P3/10
Abstract: Methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for the GIPR polypeptide conjugated to a GLP-1 receptor agonist are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises an antibody or functional fragment thereof comprising a cysteine at one or more conjugation site(s) wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue.
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