公开(公告)号：US20230212318A1

公开(公告)日：2023-07-06

申请号：US17727316

申请日：2022-04-22

Applicant: AMGEN INC.

Inventor： Wei Yan ,  Martin J. Pentony ,  Mark L. Michaels ,  Patrick Baeuerle

IPC: C07K16/46 ,  C07K14/725 ,  C07K16/28 ,  C07K16/32

CPC classification number: C07K16/468 ,  C07K14/7051 ,  C07K16/32 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/50

Abstract: Described herein are protease-activatable proteins (PABPs), which, when activated, can mediate cytolysis of target cells by effector cells. Also provided are nucleic acids encoding such PABPs and methods of making and using PABPs.

公开(公告)号：US20230212297A1

公开(公告)日：2023-07-06

申请号：US17697632

申请日：2022-03-17

Applicant: Amgen Inc.

Inventor： Luis G. Borges ,  Patrick Baeuerle ,  Wei Yan ,  Mark L. Michaels

IPC: C07K16/28 ,  C07K16/32 ,  C07K16/00 ,  C07K16/40 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/2863 ,  C07K16/00 ,  C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  C07K16/468 ,  C07K16/2803 ,  C07K16/2809 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/60 ,  C07K2317/64 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/00

Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.

公开(公告)号：US20170247476A1

公开(公告)日：2017-08-31

申请号：US15513011

申请日：2015-09-24

Applicant: AMGEN INC.

Inventor： Wei Yan ,  Martin J. Pentony ,  Mark L. Michaels ,  Patrick Baeuerle

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/32 ,  C07K14/725

CPC classification number: C07K16/468 ,  C07K14/7051 ,  C07K16/2809 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/50

Abstract: Described herein are protease-activatable proteins (PABPs), which, when activated, can mediate cytolysis of target cells by effector cells. Also provided are nucleic acids encoding such PABPs and methods of making and using PABPs.

公开(公告)号：US20160145340A1

公开(公告)日：2016-05-26

申请号：US14774309

申请日：2014-03-14

Applicant: AMGEN INC.

Inventor： Luis G. Borges ,  Patrick Baeuerle ,  Wei Yan ,  Mark L. Michaels

IPC: C07K16/28 ,  C07K16/40

Abstract: Described herein is a bispecific molecule containing an Fc polypeptide chain and immunoglobulin variable regions. Also provided are pharmaceutical formulations comprising such molecules, nucleic acids encoding such molecules, host cells containing such nucleic acids, methods of making such molecules, and methods of using such molecules.

Abstract translation: 本文描述的是含有Fc多肽链和免疫球蛋白可变区的双特异性分子。 还提供了包含这种分子的药物制剂，编码这种分子的核酸，含有这种核酸的宿主细胞，制备这种分子的方法，以及使用这种分子的方法。