公开(公告)号：US20200283504A9

公开(公告)日：2020-09-10

申请号：US16388561

申请日：2019-04-18

Applicant: AMGEN INC.

Inventor： Jeonghoon SUN ,  Lei-Ting Tony TAM ,  Mark Leo MICHAELS ,  Thomas Charles BOONE ,  Rohini DESHPANDE ,  Yue-Sheng LI ,  Huiquan HAN

IPC: C07K14/71 ,  C07K14/495

Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.

公开(公告)号：US20190389932A1

公开(公告)日：2019-12-26

申请号：US16388561

申请日：2019-04-18

Applicant: AMGEN INC.

Inventor： Jeonghoon SUN ,  Lei-Ting Tony TAM ,  Mark Leo MICHAELS ,  Thomas Charles BOONE ,  Rohini DESHPANDE ,  Yue-Sheng LI ,  Huiquan HAN

IPC: C07K14/71 ,  C07K14/495

Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.