公开(公告)号：US20150044235A1

公开(公告)日：2015-02-12

申请号：US14285576

申请日：2014-05-22

Applicant: Amgen Inc.

Inventor： Kenneth W. WALKER ,  Yue-Sheng LI ,  Thomas Charles BOONE ,  George DOELLGAST (DECEASED) ,  HoSung MIN ,  Jane TALVENHEIMO ,  Taruna ARORA ,  Frederick W. JACOBSEN

IPC: C07K16/44 ,  C07K14/575 ,  C07K14/605 ,  C07K16/24 ,  C07K14/435 ,  C07K16/18

CPC classification number: C07K16/44 ,  A61K39/39591 ,  A61K47/6817 ,  A61K47/6843 ,  C07K14/43504 ,  C07K14/575 ,  C07K14/605 ,  C07K14/66 ,  C07K16/00 ,  C07K16/18 ,  C07K16/248 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/55

Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

公开(公告)号：US20150044236A1

公开(公告)日：2015-02-12

申请号：US14285579

申请日：2014-05-22

Applicant: AMGEN INC.

Inventor： Kenneth W. WALKER ,  Yue-Sheng LI ,  Thomas Charles BOONE ,  HoSung MIN ,  Jane TALVENHEIMO ,  Taruna ARORA ,  Frederick W. JACOBSEN

IPC: C07K16/44 ,  C07K16/24 ,  C07K14/575 ,  C07K14/605 ,  C07K16/18 ,  C07K14/435

CPC classification number: C07K16/44 ,  A61K39/39591 ,  A61K47/6817 ,  A61K47/6843 ,  C07K14/43504 ,  C07K14/575 ,  C07K14/605 ,  C07K14/66 ,  C07K16/00 ,  C07K16/18 ,  C07K16/248 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/55

Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

Abstract translation: 公开了分离的抗原结合蛋白，例如但不限于抗体或抗体片段。 还公开了包含抗原结合蛋白，编码它的分离的核酸，载体，宿主细胞和用于制备它的方法中的杂交瘤的药物组合物和药物。 在一些实施方案中，抗原结合蛋白包含与其结合的1-24个药理活性化学部分，例如药理学活性多肽。

公开(公告)号：US20200283504A9

公开(公告)日：2020-09-10

申请号：US16388561

申请日：2019-04-18

Applicant: AMGEN INC.

Inventor： Jeonghoon SUN ,  Lei-Ting Tony TAM ,  Mark Leo MICHAELS ,  Thomas Charles BOONE ,  Rohini DESHPANDE ,  Yue-Sheng LI ,  Huiquan HAN

IPC: C07K14/71 ,  C07K14/495

Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.

公开(公告)号：US20190389932A1

公开(公告)日：2019-12-26

申请号：US16388561

申请日：2019-04-18

Applicant: AMGEN INC.

Inventor： Jeonghoon SUN ,  Lei-Ting Tony TAM ,  Mark Leo MICHAELS ,  Thomas Charles BOONE ,  Rohini DESHPANDE ,  Yue-Sheng LI ,  Huiquan HAN

IPC: C07K14/71 ,  C07K14/495

Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.

公开(公告)号：US20230295267A1

公开(公告)日：2023-09-21

申请号：US18206963

申请日：2023-06-07

Applicant: AMGEN INC.

Inventor： Jeonghoon SUN ,  Lei-Ting Tony TAM ,  Mark Leo MICHAELS ,  Thomas Charles BOONE ,  Rohini R. DESHPANDE ,  Yue-Sheng LI ,  Huiquan HAN

IPC: C07K14/71 ,  C07K14/495

CPC classification number: C07K14/71 ,  C07K14/495 ,  A61K38/00

Abstract: The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.

公开(公告)号：US20170190793A1

公开(公告)日：2017-07-06

申请号：US15405233

申请日：2017-01-12

Applicant: AMGEN INC.

Inventor： Kenneth W. WALKER ,  Yue-Sheng LI ,  Thomas Charles BOONE ,  George DOELLGAST (DECEASED) ,  HoSung MIN ,  Jane TALVENHEIMO ,  Taruna ARORA ,  Frederick W. JACOBSEN

IPC: C07K16/44 ,  C07K14/66 ,  C07K14/605

CPC classification number: C07K16/44 ,  A61K39/39591 ,  A61K47/6817 ,  A61K47/6843 ,  C07K14/43504 ,  C07K14/575 ,  C07K14/605 ,  C07K14/66 ,  C07K16/00 ,  C07K16/18 ,  C07K16/248 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/55

Abstract: Disclosed is an isolated antigen binding protein, such as but not limited to, an antibody or antibody fragment. Also disclosed are pharmaceutical compositions and medicaments comprising the antigen binding protein, isolated nucleic acid encoding it, vectors, host cells, and hybridomas useful in methods of making it. In some embodiments the antigen binding protein comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.