公开(公告)号：US10328100B2

公开(公告)日：2019-06-25

申请号：US14744726

申请日：2015-06-19

Applicant: Amorphical Ltd.

Inventor： Shmuel Bentov ,  Amir Sagi ,  Amir Berman ,  Assaf Shechter

IPC: A61K9/00 ,  A61K31/66 ,  A61K33/10 ,  A61K38/17 ,  C07K14/435

Abstract: Provided are compositions containing amorphous calcium carbonate (ACC), and at least one phosphorylated peptide which stabilizes the amorphous form of said calcium carbonate. Particularly, the peptide can be selected from crustacean proteins, also provided by the invention, namely GAP65, GAP22, GAP21, and GAP12 (also indicated herein as GAP10). The compositions are useful in pharmaceutical and nutraceutical formulations.

公开(公告)号：US10688124B2

公开(公告)日：2020-06-23

申请号：US16050651

申请日：2018-07-31

Applicant: AMORPHICAL LTD.

Inventor： Amir Sagi ,  Assaf Shechter ,  Galit Shaltiel-Gold ,  Michal Daniely ,  Oren Meiron

IPC: A61K33/10 ,  A61K35/612 ,  A61K31/663

Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.

公开(公告)号：US20150056306A1

公开(公告)日：2015-02-26

申请号：US14364992

申请日：2012-12-13

Applicant: AMORPHICAL LTD

Inventor： Amir Sagi ,  Assaf Shechter ,  Galit Shaltiel-Gold ,  Michal Daniely ,  Oren Meiron

IPC: A61K33/10 ,  A61K31/663

CPC classification number: A61K33/10 ,  A61K31/663 ,  A61K35/612

Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.

Abstract translation: 提供了用于治疗钙吸收不良的方法和与钙吸收不良相关的病症，使用含有稳定的无定形碳酸钙的组合物。 进一步提供的是使用与骨吸收抑制剂组合施用所述组合物来增加骨代谢相关障碍，疾病或病症中的骨矿物质密度的方法。

公开(公告)号：US10064890B2

公开(公告)日：2018-09-04

申请号：US14364992

申请日：2012-12-13

Applicant: AMORPHICAL LTD

Inventor： Amir Sagi ,  Assaf Shechter ,  Galit Shaltiel-Gold ,  Michal Daniely ,  Oren Meiron

IPC: A61K33/10 ,  A61K31/663 ,  A61K35/612

Abstract: Provided are methods for treating calcium malabsorption and conditions associated with calcium malabsorption, employing the administration of a composition containing stable amorphous calcium carbonate. Further provided are methods for increasing bone mineral density in a bone metabolism associated disorders, diseases or conditions, employing the administration of said composition in combination with a bone resorption inhibitor.