公开(公告)号：US12115184B2

公开(公告)日：2024-10-15

申请号：US17343471

申请日：2021-06-09

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Yigal Dov Blum ,  Hagay Moshe ,  Ben Ashkenazi

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/10 ,  A61K9/14 ,  A61K47/24 ,  A61P31/00 ,  A61P35/00

CPC classification number: A61K33/10 ,  A61K9/0019 ,  A61K9/0056 ,  A61K9/0073 ,  A61K9/10 ,  A61K9/143 ,  A61K47/24 ,  A61P31/00 ,  A61P35/00

Abstract: The present invention provides solid compositions of amorphous calcium carbonate (ACC) and a polyphosphate, bisphosphonate or pharmaceutical salts thereof as a stabilizer. Said stabilizers stabilizes the ACC and prevent crystallization to crystalline calcium carbonate (CCC) for a long period of time, even in an aqueous suspension. The invention further provides pharmaceutical composition comprising the solid ACC compositions as well their use in treating of certain diseases and conditions.

公开(公告)号：US20230181627A1

公开(公告)日：2023-06-15

申请号：US18106735

申请日：2023-02-07

Applicant: AMORPHICAL LTD.

Inventor： Yigal Blum ,  Yosef Ben ,  Sharon Hershkovitz

IPC: A61K33/10 ,  C01F11/18 ,  A23L33/16 ,  A23C9/152 ,  A23C19/09 ,  A23C9/13 ,  A61K9/00 ,  A61K9/10 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/40

CPC classification number: A61K33/10 ,  C01F11/185 ,  A23L33/16 ,  C01F11/18 ,  A23C9/1522 ,  A23C19/0921 ,  A23C9/1322 ,  A61K9/0014 ,  A61K9/10 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/34 ,  A61K47/40 ,  C01P2002/02 ,  A23V2002/00 ,  A23C13/12

Abstract: The present invention provides stabilized amorphous calcium carbonate (ACC) formulations, comprising ACC and a non-aqueous liquid carrier in which the ACC is dispersed. The present invention further provides cosmetic and pharmaceutical compositions comprising ACC.

公开(公告)号：US20230124095A1

公开(公告)日：2023-04-20

申请号：US17909549

申请日：2021-01-28

Applicant: AMORPHICAL LTD.

Inventor： Yossi BEN ,  Yigal BLUM ,  Yehudit NATAN

IPC: A61K33/10 ,  A61K9/00 ,  A61K31/728 ,  A61P29/00 ,  A61P35/00 ,  A61P11/00 ,  A61P31/14 ,  A61K9/16

Abstract: The preset invention is directed to ACC particles stabilized by at least one stabilizing agent, a pharmaceutical composition including same, and methods of using same, such as for treating or preventing an acidosis-related disease or condition in a subject in need thereof.

公开(公告)号：US11207347B2

公开(公告)日：2021-12-28

申请号：US16934689

申请日：2020-07-21

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61P21/00 ,  A61P15/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US11052108B2

公开(公告)日：2021-07-06

申请号：US16343463

申请日：2017-10-23

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben

IPC: A61K33/10 ,  A23L29/00 ,  A61P35/02 ,  A61K9/00 ,  A61K31/66

Abstract: The present invention provides compositions and methods of treating a leukemia, including chronic lymphocytic leukemia, wherein the method comprises administering a stabilized amorphous calcium carbonate to a person in need thereof.

公开(公告)号：US20200345764A1

公开(公告)日：2020-11-05

申请号：US16934689

申请日：2020-07-21

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: A61K33/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/10 ,  A61P21/00 ,  A61P15/08 ,  A61K47/02 ,  A61K47/12 ,  A61K47/24 ,  A61K47/26 ,  C12N5/073 ,  C12N5/076 ,  C12N5/071

Abstract: Stabilized amorphous calcium carbonate (ACC) for treatment of several neurological, muscular and infertility diseases and conditions is provided. In particular, the stabilized ACC may be used in the treatment of axonal defects and muscular dystrophy. In addition, provided are improved methods used in assistant reproductive technology. Examples of such methods are in vitro fertilization and improvement of sperm quality. The improved IVF method, for example, comprises addition of the stabilized ACC to the cell culture medium in which the stages of fertilization and embryo development occurs.

公开(公告)号：US09550878B2

公开(公告)日：2017-01-24

申请号：US14418034

申请日：2013-08-07

Applicant: AMORPHICAL LTD.

Inventor： Oren Meiron ,  Binyamin Ashkenazi

IPC: C01F11/18 ,  C08K3/26 ,  C09C1/02 ,  B82Y30/00 ,  A61K33/10 ,  C08K5/092 ,  C08K5/17 ,  C08K5/521 ,  C08K5/5399 ,  C08L5/00 ,  D21H17/00

CPC classification number: C09C1/021 ,  A23L33/16 ,  A23V2002/00 ,  A61K33/10 ,  B82Y30/00 ,  C01F11/182 ,  C01F11/183 ,  C01F11/185 ,  C01P2002/02 ,  C01P2002/72 ,  C01P2002/82 ,  C01P2004/30 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/22 ,  C01P2006/36 ,  C01P2006/82 ,  C08K3/26 ,  C08K5/092 ,  C08K5/175 ,  C08K5/521 ,  C08K5/5399 ,  C08K2003/265 ,  C08L5/00 ,  C09D17/004 ,  C09J11/04 ,  D21H17/74

Abstract: Provided is a method for preparing a stable amorphous calcium carbonate (ACC), which can be obtained either in suspension or as a powder. The method comprises stepwise combination of a soluble calcium salt, a soluble carbonate, a first and second stabilizer, and a water miscible organic solvent as described herein. The present invention further relates to stable ACC suspensions and dry powders produced by the method of the present invention.

Abstract translation: 提供一种制备稳定的无定形碳酸钙（ACC）的方法，其可以以悬浮液或粉末形式获得。 该方法包括如本文所述的可溶性钙盐，可溶性碳酸盐，第一和第二稳定剂以及水混溶性有机溶剂的逐步组合。 本发明还涉及通过本发明的方法制备的稳定的ACC悬浮液和干粉。

公开(公告)号：US12060573B2

公开(公告)日：2024-08-13

申请号：US16069774

申请日：2017-01-17

Applicant: AMORPHICAL LTD.

Inventor： Yosef Ben ,  Abraham Shahar ,  Amir Arav

IPC: C12N5/00 ,  C12N5/073 ,  C12N5/075 ,  C12N5/076 ,  C12N5/077 ,  C12N5/0775 ,  C12N5/0793

CPC classification number: C12N5/0018 ,  C12N5/0604 ,  C12N5/0609 ,  C12N5/061 ,  C12N5/0619 ,  C12N5/0658 ,  C12N5/0663 ,  C12N2500/14

Abstract: Stabilized amorphous calcium carbonate (ACC) as a supplement of cell culture media and the cell culture medium supplements comprising stabilized ACC are provided. In particular the stabilized ACC is useful for enhancing the growth of cell and tissue cultures, gametes and embryos in vitro.

公开(公告)号：US11602542B2

公开(公告)日：2023-03-14

申请号：US15329677

申请日：2015-07-30

Applicant: AMORPHICAL LTD.

Inventor： Yigal Blum ,  Yosef Ben ,  Sharon Hershkovitz

IPC: A61K33/10 ,  C01F11/18 ,  A23L33/16 ,  A23C9/152 ,  A23C9/13 ,  A61K9/00 ,  A61K9/10 ,  A61K47/14 ,  A23C19/09 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34 ,  A61K47/40 ,  A23C13/12 ,  A23C11/00 ,  A23C19/068 ,  A23C19/076

Abstract: The present invention provides stabilized amorphous calcium carbonate (ACC) formulations, comprising ACC and a non-aqueous liquid carrier in which the ACC is dispersed. The present invention further provides cosmetic and pharmaceutical compositions comprising ACC.

公开(公告)号：US20220313729A1

公开(公告)日：2022-10-06

申请号：US17624612

申请日：2020-07-23

Applicant: AMORPHICAL LTD

Inventor： Yossi Ben ,  Yigal Dov Blum

IPC: A61K33/10 ,  A23L33/00 ,  A61K9/00 ,  A23L33/16 ,  A61P43/00

Abstract: The present invention provides methods for enhancing and improving athletic performances of both professional and non-professional athletes by administering compositions comprising stabilized amorphous calcium carbonate. The enhanced athletic performances result among others from enhanced muscle performances, enhanced recovery and endurance.