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公开(公告)号:US10851063B2
公开(公告)日:2020-12-01
申请号:US16151798
申请日:2018-10-04
发明人: William Dubay , Alex Nichols , Wei Chen , Alec Brozell , Ajay Ryerson
IPC分类号: C07D221/28 , C07C59/255
摘要: A method for producing substantially pure levorphanol and related compounds, when compared to the conventional process, is provided. In particular, a method for producing substantially pure levorphanol tartrate dihydrate is described. Also described are compositions comprising levorphanol and related compounds, particularly compositions comprising levorphanol tartrate dihydrate, levomethorphan, and norlevorphanol in which the levomethorphan and norlevorphanol are present in the composition in reduced levels.